Platelet count, aspirin use, and characteristics of host inflammatory responses in colorectal cancer

Autor: Juha P. Väyrynen, Sara A. Väyrynen, Päivi Sirniö, Ilkka Minkkinen, Kai Klintrup, Toni Karhu, Jyrki Mäkelä, Karl-Heinz Herzig, Tuomo J. Karttunen, Anne Tuomisto, Markus J. Mäkinen

Publikováno v: Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-13 (2019)

Abstract Background Platelets not only contribute to hemostasis but also to the regulation of inflammatory reactions and cancer pathogenesis. We hypothesized that blood platelet count would be associated with systemic inflammation, the densities of t

Externí odkaz: https://doaj.org/article/cdb7cee9f9f1423098398a7819b66244

Decreased serum apolipoprotein A1 levels are associated with poor survival and systemic inflammatory response in colorectal cancer

Autor: Päivi Sirniö, Juha P. Väyrynen, Kai Klintrup, Jyrki Mäkelä, Markus J. Mäkinen, Tuomo J. Karttunen, Anne Tuomisto

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)

Abstract Recent studies have reported of an association between high serum apolipoprotein A1 (APOA1) levels and favorable prognosis in several malignancies, while the significance of apolipoprotein B (APOB) in cancer is less well-known. In this study

Externí odkaz: https://doaj.org/article/630bba1648fa4f389f24a9278b72195e

A prognostic score based on B cell and plasma cell densities compared to T cell densities in colorectal cancer

Autor: Henna Karjalainen, Päivi Sirniö, Anne Tuomisto, Markus J. Mäkinen, Juha P. Väyrynen

Publikováno v: International Journal of Colorectal Disease. 38

Purpose The purpose of this study was to compare a B cell/plasma cell–based scoring system to T cell score and evaluate their prognostic value in colorectal cancer. Methods We used immunohistochemistry to analyze the expression of CD20, CD138, CD3,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdae0608fd03a456165caf6cc3acad86
https://doi.org/10.1007/s00384-023-04322-y

Systemic inflammation is associated with circulating cell death released keratin 18 fragments in colorectal cancer

Autor: Juha P. Väyrynen, Jarosław Walkowiak, Shivaprakash Jagalur Mutt, Jyrki Mäkelä, Anne Tuomisto, Markus J. Mäkinen, Karl-Heinz Herzig, Tuomo J. Karttunen, Kai Klintrup, Päivi Sirniö

Publikováno v: Oncoimmunology
article-version (VoR) Version of Record
OncoImmunology, Vol 9, Iss 1 (2020)

Systemic inflammation is a stage-independent marker of poor prognosis in colorectal cancer (CRC), activated in a complex, multifactorial process. It has been proposed that one of the main factors driving systemic inflammation may be tumor necrosis. K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b12eeb08ace531050f1c8c60fb6208
https://doi.org/10.1080/2162402x.2020.1783046

Serum enterolactone concentrations are low in colon but not in rectal cancer patients

Autor: Anne Tuomisto, Shivaprakash Jagalur Mutt, Natalja P. Nørskov, Jyrki Mäkelä, Kai Klintrup, Karl-Heinz Herzig, Knud Erik Bach Knudsen, Juha P. Väyrynen, Markus J. Mäkinen, Päivi Sirniö

Publikováno v: Tuomisto, A, Norskov, N P, Sirnio, P, Vayrynen, J P, Mutt, S J, Klintrup, K, Makela, J, Knudsen, K E B, Makinen, M J & Herzig, K-H 2019, ' Serum enterolactone concentrations are low in colon but not in rectal cancer patients ', Scientific Reports, vol. 9, 11209 . https://doi.org/10.1038/s41598-019-47622-6
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports

The dietary lignan metabolite, enterolactone, has been suggested to have anti-cancer functions, and high serum enterolactone concentrations have been associated with decreased risk of breast and prostate cancers. We hypothesized that serum enterolact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ade96daf5b75720ff90ba98ceeae098
https://pure.au.dk/portal/da/publications/serum-enterolactone-concentrations-are-low-in-colon-but-not-in-rectal-cancer-patients(0a07c9f3-7db9-4532-9316-420d75d5e7e1).html