Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Päivi Pihlajamaa"'
Autor:
Kimmo Palin, Esa Pitkänen, Mikko Turunen, Biswajyoti Sahu, Päivi Pihlajamaa, Teemu Kivioja, Eevi Kaasinen, Niko Välimäki, Ulrika A. Hänninen, Tatiana Cajuso, Mervi Aavikko, Sari Tuupanen, Outi Kilpivaara, Linda van den Berg, Johanna Kondelin, Tomas Tanskanen, Riku Katainen, Marta Grau, Heli Rauanheimo, Roosa-Maria Plaketti, Aurora Taira, Päivi Sulo, Tuomo Hartonen, Kashyap Dave, Bernhard Schmierer, Sandeep Botla, Maria Sokolova, Anna Vähärautio, Kornelia Gladysz, Halit Ongen, Emmanouil Dermitzakis, Jesper Bertram Bramsen, Torben Falck Ørntoft, Claus Lindbjerg Andersen, Ari Ristimäki, Anna Lepistö, Laura Renkonen-Sinisalo, Jukka-Pekka Mecklin, Jussi Taipale, Lauri A. Aaltonen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
In this study the authors examine the allelic imbalance (AI) landscape of colorectal cancer, reporting loss of TP53 as a driver of AI. They use CRISPR-Cas9 screens to identify 79 genes (within AI regions) regulating cell growth and identify a network
Externí odkaz:
https://doaj.org/article/0d1e862be9834942b8b1513c12b2e466
Autor:
Otto Kauko, Mikko Turunen, Päivi Pihlajamaa, Antti Häkkinen, Rayner M. L. Queiroz, Mirva Pääkkönen, Sami Ventelä, Massimiliano Gaetani, Susanna Lundström, Antonio Murgia, Biswajyoti Sahu, Johannes Routila, Heikki Irjala, Julian L. Griffin, Kathryn S. Lilley, Teemu Kivioja, Sampsa Hautaniemi, Jussi Taipale
Mutations in hundreds of genes have been associated with formation of human cancer, with different oncogenic lesions prevalent in different cancer types. Yet, the malignant phenotype is simple, characterized by unrestricted growth of cells that invad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b40c7a52db36e705563718efdc482eb
https://doi.org/10.1101/2022.09.27.509636
https://doi.org/10.1101/2022.09.27.509636
Autor:
Biswajyoti Sahu, Tuomo Hartonen, Päivi Pihlajamaa, Bei Wei, Kashyap Dave, Fangjie Zhu, Eevi Kaasinen, Katja Lidschreiber, Michael Lidschreiber, Carsten O. Daub, Patrick Cramer, Teemu Kivioja, Jussi Taipale
Publikováno v:
Nature Genetics
Funder: Sigrid Juséliuksen Säätiö (Sigrid Jusélius Foundation); doi: https://doi.org/10.13039/501100006306
Funder: Jane ja Aatos Erkon Säätiö (Jane and Aatos Erkko Foundation); doi: https://doi.org/10.13039/501100004012
Funder: Syö
Funder: Jane ja Aatos Erkon Säätiö (Jane and Aatos Erkko Foundation); doi: https://doi.org/10.13039/501100004012
Funder: Syö
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a921b9355f20739b39b8d1b6f0a9a6f
MYC is an oncogenic transcription factor that controls major pathways promoting cell growth and proliferation. MYC has been implicated in the regulation of large number of genes, but the exact target genes responsible for its proliferative effects ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d93f722ea130ff4ce00b6ca0640093c8
https://doi.org/10.1101/2021.09.17.460746
https://doi.org/10.1101/2021.09.17.460746
Autor:
Eevi Kaasinen, Kashyap Dave, Jussi Taipale, Patrick Cramer, Teemu Kivioja, Katja Lidschreiber, Michael Lidschreiber, Päivi Pihlajamaa, Fangjie Zhu, Carsten O. Daub, Tuomo Hartonen, Biswajyoti Sahu, Bei Wei
DNA determines where and when genes are expressed, but the full set of sequence determinants that control gene expression is not known. To obtain a global and unbiased view of the relative importance of different sequence determinants in gene express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5d32fc50b1352855d9c5d9d6a9897b8
https://doi.org/10.1101/2021.03.18.435942
https://doi.org/10.1101/2021.03.18.435942
Autor:
Lauri A. Aaltonen, Kaiyang Zhang, Alejandra Cervera, Jussi Taipale, Päivi Pihlajamaa, Ari Ristimäki, Kimmo Palin, Biswajyoti Sahu, Saija Ahonen, Sampsa Hautaniemi
Publikováno v:
Oncogene
Cancer is the most complex genetic disease known, with mutations implicated in more than 250 genes. However, it is still elusive which specific mutations found in human patients lead to tumorigenesis. Here we show that a combination of oncogenes that
Autor:
Ilkka Heiskanen, Pekka Katajisto, Päivi Pihlajamaa, Pia Vahteristo, Camilla Schalin-Jäntti, Olli Carpén, Lauri A. Aaltonen, Noora Andersson, Lauri J. Sipilä, Jussi Taipale, Riku Katainen, Iikki Donner, Simona Bramante, Päivi Sulo, Nalle Pentinmikko, Kaisa Lehti, Anna Kuosmanen, Erika Gucciardo, Johanna Arola, Mervi Aavikko, Eevi Kaasinen, Jukka-Pekka Mecklin, Samantha Martin, Ari Ristimäki
Publikováno v:
Human Molecular Genetics
Many hereditary cancer syndromes are associated with an increased risk of small and large intestinal adenocarcinomas. However, conditions bearing a high risk to both adenocarcinomas and neuroendocrine tumors are yet to be described. We studied a fami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5b0080e1acc11c147c2829754d8692
http://urn.fi/URN:NBN:fi:jyu-202202091457
http://urn.fi/URN:NBN:fi:jyu-202202091457
Autor:
Lauri A. Aaltonen, Saija Ahonen, Kimmo Palin, Jussi Taipale, Kaiyang Zhang, Biswajyoti Sahu, Päivi Pihlajamaa, Alejandra Cervera, Sampsa Hautaniemi, Ari Ristimäki
Cancer is the most complex genetic disease known, with mutations implicated in more than 250 genes. However, it is still elusive which specific mutations found in human patients lead to tumorigenesis. Here we show that a combination of oncogenes that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99f796c5a44e68e6f0eb5fabe774d5ab
https://doi.org/10.1101/525600
https://doi.org/10.1101/525600
Autor:
Aurora Taira, Emmanouil T. Dermitzakis, Sandeep Kumar Botla, Jussi Taipale, Päivi Sulo, Ulrika A. Hänninen, Bernhard Schmierer, Roosa-Maria Plaketti, Kashyap Dave, Niko Välimäki, Tatiana Cajuso, Torben F. Ørntoft, Anna Vähärautio, Päivi Pihlajamaa, Mervi Aavikko, Maria Sokolova, Halit Ongen, Sari Tuupanen, Johanna Kondelin, Outi Kilpivaara, Anna Lepistö, Kornelia Gladysz, Jukka-Pekka Mecklin, Esa Pitkänen, Eevi Kaasinen, Heli Rauanheimo, Marta Grau, Lauri A. Aaltonen, Mikko P. Turunen, Ari Ristimäki, Linda van den Berg, Riku Katainen, Tuomo Hartonen, Jesper B. Bramsen, Claus L. Andersen, Teemu Kivioja, Tomas Tanskanen, Kimmo Palin, Biswajyoti Sahu, Laura Renkonen-Sinisalo
Publikováno v:
Palin, K, Pitkänen, E, Turunen, M, Sahu, B, Pihlajamaa, P, Kivioja, T, Kaasinen, E, Välimäki, N, Hänninen, U A, Cajuso, T, Aavikko, M, Tuupanen, S, Kilpivaara, O, van den Berg, L, Kondelin, J, Tanskanen, T, Katainen, R, Grau, M, Rauanheimo, H, Plaketti, R-M, Taira, A, Sulo, P, Hartonen, T, Dave, K, Schmierer, B, Botla, S, Sokolova, M, Vähärautio, A, Gladysz, K, Ongen, H, Dermitzakis, E, Bramsen, J B, Ørntoft, T F, Andersen, C L, Ristimäki, A, Lepistö, A, Renkonen-Sinisalo, L, Mecklin, J-P, Taipale, J & Aaltonen, L A 2018, ' Contribution of allelic imbalance to colorectal cancer ', Nature Communications, vol. 9, 3664 . https://doi.org/10.1038/s41467-018-06132-1
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Nature Communications
Nature Communications, Vol. 9, No 1 (2018) P. 3664
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Nature Communications
Nature Communications, Vol. 9, No 1 (2018) P. 3664
Point mutations in cancer have been extensively studied but chromosomal gains and losses have been more challenging to interpret due to their unspecific nature. Here we examine high-resolution allelic imbalance (AI) landscape in 1699 colorectal cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12af55a05ccaa6e0100715add27700fa
http://urn.fi/URN:NBN:fi:jyu-201809174145
http://urn.fi/URN:NBN:fi:jyu-201809174145
Publikováno v:
Endocrine Reviews. 36:357-384
The physiological androgens testosterone and 5α-dihydrotestosterone regulate the development and maintenance of primary and secondary male sexual characteristics through binding to the androgen receptor (AR), a ligand-dependent transcription factor.