Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Päivi Lindholm"'
Autor:
Jenni E. Anttila, Olli S. Mattila, Hock-Kean Liew, Kert Mätlik, Eero Mervaala, Päivi Lindholm, Maria Lindahl, Perttu J. Lindsberg, Kuan-Yin Tseng, Mikko Airavaara
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-24 (2024)
Abstract Mesencephalic astrocyte-derived neurotrophic factor (MANF) has cytoprotective effects on various injuries, including cerebral ischemia, and it can promote recovery even when delivered intracranially several days after ischemic stroke. In the
Externí odkaz:
https://doaj.org/article/cd3742bb5b894f548ea64724f99c629c
Autor:
Emmi Pakarinen, Päivi Lindholm
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by gradual loss of midbrain dopamine neurons, leading to impaired motor function. Preclinical studies have indicated cerebral dopamine neurotrophic factor (CDNF) and
Externí odkaz:
https://doaj.org/article/ab1e912e62f74c58aa680c30a2f99210
Autor:
Vera Kovaleva, Li-Ying Yu, Larisa Ivanova, Olesya Shpironok, Jinhan Nam, Ave Eesmaa, Esa-Pekka Kumpula, Sven Sakson, Urve Toots, Mart Ustav, Juha T. Huiskonen, Merja H. Voutilainen, Päivi Lindholm, Mati Karelson, Mart Saarma
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112066- (2023)
Summary: Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-located protein with cytoprotective effects in neurons and pancreatic β cells in vitro and in models of neurodegeneration and diabetes in vivo. Howe
Externí odkaz:
https://doaj.org/article/5219a8ab6680491fa637a30370d90b44
Publikováno v:
BMC Genetics, Vol 18, Iss 1, Pp 1-19 (2017)
Abstract Background Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) and Cerebral Dopamine Neurotrophic Factor (CDNF) form an evolutionarily conserved family of neurotrophic factors. Orthologues for MANF/CDNF are the only neurotrophic facto
Externí odkaz:
https://doaj.org/article/02a492723c6d44d59d1df4b281eba4cd
Publikováno v:
Neurobiology of Disease, Vol 97, Iss , Pp 90-102 (2017)
Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF) promote the survival of midbrain dopaminergic neurons which degenerate in Parkinson's disease (PD). However, CDNF and MANF are structurally an
Externí odkaz:
https://doaj.org/article/3b8ae70812f149bca90dad546b2a5e2b
Autor:
Tatiana Danilova, Emilia Galli, Emmi Pakarinen, Erik Palm, Päivi Lindholm, Mart Saarma, Maria Lindahl
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Mesencephalic astrocyte-derived neurotrophic factor (MANF) and cerebral dopamine neurotrophic factor (CDNF) form a family of atypical growth factors discovered for their neuroprotective properties in the central nervous system (CNS) in animal models
Externí odkaz:
https://doaj.org/article/8030f1f6315340aba45a979396c93b13
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
BackgroundMesencephalic astrocyte-derived neurotrophic factor (MANF) and cerebral dopamine neurotrophic factor (CDNF) promote the survival of midbrain dopamine neurons in animal models of Parkinson’s disease (PD). However, little is known about end
Externí odkaz:
https://doaj.org/article/b8173a31e842408b8f0679ea40506097
Autor:
Emilia Galli, Päivi Lindholm, Leena-Stiina Kontturi, Mart Saarma, Arto Urtti, Marjo Yliperttula
Publikováno v:
Cell Transplantation, Vol 28 (2019)
Cerebral dopamine neurotrophic factor (CDNF) shows beneficial effects in rodent models of Parkinson’s and Alzheimer’s disease. The brain is a challenging target for protein therapy due to its exclusive blood–brain barrier. Hence, the therapeuti
Externí odkaz:
https://doaj.org/article/8f23ad08c57b4176a345db4d261233c1
Autor:
Diego Balboa, Jonna Saarimäki-Vire, Daniel Borshagovski, Mantas Survila, Päivi Lindholm, Emilia Galli, Solja Eurola, Jarkko Ustinov, Heli Grym, Hanna Huopio, Juha Partanen, Kirmo Wartiovaara, Timo Otonkoski
Publikováno v:
eLife, Vol 7 (2018)
Insulin gene mutations are a leading cause of neonatal diabetes. They can lead to proinsulin misfolding and its retention in endoplasmic reticulum (ER). This results in increased ER-stress suggested to trigger beta-cell apoptosis. In humans, the mech
Externí odkaz:
https://doaj.org/article/b0cfaf207d5d4df1a0be08c4d59cd97f
Autor:
Maria Lindahl, Tatiana Danilova, Erik Palm, Päivi Lindholm, Vootele Võikar, Elina Hakonen, Jarkko Ustinov, Jaan-Olle Andressoo, Brandon K. Harvey, Timo Otonkoski, Jari Rossi, Mart Saarma
Publikováno v:
Cell Reports, Vol 7, Iss 2, Pp 366-375 (2014)
Summary: All forms of diabetes mellitus (DM) are characterized by the loss of functional pancreatic β cell mass, leading to insufficient insulin secretion. Thus, identification of novel approaches to protect and restore β cells is essential for the
Externí odkaz:
https://doaj.org/article/158790f8db0844df824b058c71a05226