Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Päivi Liesi"'
Autor:
Päivi Liesi
Publikováno v:
Future Neurology. 4:561-574
Successful treatment of neurodegenerative diseases and CNS trauma are the most intractable problems in modern medicine. Numerous reports have shown the strong role that laminins have on the survival, regeneration and development of various types of c
Publikováno v:
Journal of Neuroscience Research. 85:2045-2058
Our earlier studies indicate that the KDI tripeptide of gamma1 laminin reverts paralysis and protects adult rat CNS from excitotoxicity of glutamate and from oxidative stress. Here we show that gamma1 laminin is selectively overexpressed in reactive
Publikováno v:
Journal of Neuroscience Research. 84:655-665
Our previous studies indicate that the KDI (Lys-Asp-Ile) tripeptide of γ1 laminin protects central neurons from mechanical trauma and excitotoxicity. At least part of the neuroprotective effect of the KDI tripeptide may be mediated by its inhibitory
Autor:
Päivi Liesi
Publikováno v:
Future Neurology. 1:349-352
Understanding molecular mechanisms of neuronal viability & neurite outgrowth At present, the treatment of CNS trauma and disease remains largely one of medicine’s unachieved goals. For example, current treatments of spinal injuries and stroke are o
Publikováno v:
Journal of Neuroscience Research. 81:797-804
Previous work from this laboratory indicates that the KDI (Lys-Asp-Ile) domain of γ1-laminin promotes functional regeneration of adult rat spinal cord injuries and protects adult rat hippocampal neurons against massive neuronal death induced by intr
Publikováno v:
Journal of Neuroscience Research. 78:403-410
Regeneration in the central nervous system (CNS) of adult mammals is hampered by formation of a glial scar and by proteins released from the myelin sheaths of injured neuronal pathways. Our recent data indicate that the KDI (Lys-Asp-Ile) domain of ga
Publikováno v:
Journal of Neuroscience Research. 78:411-419
Recent data indicate that the soluble KDI domain of γ1 laminin promotes survival and neurite outgrowth of human central neurons in vitro (Liebkind et al.[2003] J Neurosci Res 73:637–643), and seems to neutralize both glia- and myelin-derived signa
Publikováno v:
Free Radical Research. 38:271-282
Nitroxyl anion or its conjugate acid (NO-/HNO) and nitric oxide (NO) may both have pro-oxidative and cytotoxic properties. Superoxide dismutase (SOD) enzyme has been shown to convert reversibly HNO to NO. Mutations found in the SOD enzyme in some fam
Publikováno v:
Journal of Neuroscience Research. 71:338-352
Immunocytochemistry, in situ hybridization and Matrigel-embedded cultures were used to investigate the distribution of laminins during development of the human embryonic spinal cord (7-11 weeks). Our results indicate that alpha 1, beta 1, beta 3 and
Autor:
Markus Wiksten, Chuang C. Chiueh, Mikaela Moed, Päivi Liesi, Pekka Rauhala, Raimo K. Tuominen, Antiii J Väänänen, Teemu Helkamaa
Publikováno v:
Free Radical Research. 37:381-389
In this study, we investigated the hypothesis that the pro-oxidative properties of Angeli's salt (AS), a nitroxyl anion (HNO/NO-) releasing compound, cause neurotoxicity in dopaminergic neurons. The pro-oxidative properties were demonstrated in vitro