Výsledky vyhledávání - "Päivi Järvensivu"

Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice

Autor: Poutanen, Taija Heinosalo, Kalle T. Rytkönen, Niina Saarinen, Päivi Järvensivu, Pauliina Damdimopoulou, Leena Strauss, Satu Orasniemi, Petricia Horshauge, Michael Gabriel, Pasi Koskimies, Claes Ohlsson, Pauliina Kronqvist, Matti

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 9; Pages: 4815

Hydroxysteroid (17beta) dehydrogenase type 1 (HSD17B1) is an enzyme that converts estrone to estradiol, while adenomyosis is an estrogen-dependent disease with poorly understood pathophysiology. In the present study, we show that mice universally ove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::0d4aa10a403bd4bdb0486376da306fc0

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Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice

Autor: Taija, Heinosalo, Kalle T, Rytkönen, Niina, Saarinen, Päivi, Järvensivu, Pauliina, Damdimopoulou, Leena, Strauss, Satu, Orasniemi, Petricia, Horshauge, Michael, Gabriel, Pasi, Koskimies, Claes, Ohlsson, Pauliina, Kronqvist, Matti, Poutanen

Publikováno v: International journal of molecular sciences. 23(9)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a4f1da12c68360dfbc53bd0328937175
https://pubmed.ncbi.nlm.nih.gov/35563206

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HSD17B1 expression induces inflammation-aided rupture of mammary gland myoepithelium

Autor: Pauliina Kronqvist, Janne Hakkarainen, Niina Saarinen, Taija Heinosalo, Päivi Järvensivu, Matti Poutanen

Publikováno v: Endocrine-Related Cancer. 25:393-406

Hydroxysteroid (17-beta) dehydrogenase type 1 (HSD17B1) converts low-active estrogen estrone to highly active estradiol. Estradiol is necessary for normal postpubertal mammary gland development; however, elevated estradiol levels increase mammary tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5390c5504c0da6bfb98667c69eee9ef
https://doi.org/10.1530/erc-17-0476

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HSD17B1 expression enhances estrogen signaling stimulated by the low active estrone, evidenced by an estrogen responsive element-driven reporter gene in vivo

Autor: Pasi Koskimies, Niina Saarinen, Matti Poutanen, Päivi Järvensivu, Michael Awosanya, Taija Saloniemi-Heinonen

Publikováno v: Chemico-Biological Interactions. 234:126-134

Hydroxysteroid (17beta) dehydrogenase 1 (HSD17B1) belongs to a family of short-chain-dehydrogenases. The enzyme utilizes NAD(P) and NAD(P)H as cofactors, and catalyzes the reversible reaction between estrone (E1) and estradiol (E2) in vitro. Of these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1678a6bcbf158e32d0da359d99279e
https://doi.org/10.1016/j.cbi.2015.01.008

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Sex Steroid-Dependent and -Independent Action of Hydroxysteroid (17β) Dehydrogenase 2: Evidence from Transgenic Female Mice

Autor: Päivi Järvensivu, Matti Poutanen, Pirjo Pakarinen, Taija Saloniemi, Aino Rönnblad, ZhongYi Shen

Publikováno v: Endocrinology. 150:4941-4949

We have recently generated transgenic (TG) mice overexpressing human hydroxysteroid (17β) dehydrogenase 2 enzyme (HSD17B2TG mice) under the ubiquitous chicken β-actin promoter. As shown in the present study, the HSD17B2TG female mice presented with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d8c13e6ec91f76664ea3512472857a
https://doi.org/10.1210/en.2009-0670

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Novel hydroxysteroid (17beta) dehydrogenase 1 inhibitors reverse estrogen-induced endometrial hyperplasia in transgenic mice

Autor: Tarja Lamminen, Roberto Dina, Päivi Järvensivu, Jan J. Brosens, Antti Perheentupa, Heli Jokela, Pasi Koskimies, Sadaf Ghaem-Maghami, Matti Poutanen, Sari Mäkelä, Taija Saloniemi, Pauliina Damdimopoulou, Harry Kujari

Publikováno v: The American journal of pathology. 176(3)

Local estrogen production plays a key role in proliferative endometrial disorders, such as endometrial hyperplasia and cancer. Hydroxysteroid (17beta) dehydrogenase 1 (HSD17B1) is an enzyme that catalyzes with high efficiency the conversion of weakly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7537f9022aaa07849fe63f0deb84400
https://pubmed.ncbi.nlm.nih.gov/20093485

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Abstract 1402: A reporter mouse model reveals that human CYP19A1 (aromatase) gene expression is induced in breast cancer xenograft stroma and surrounding mammary gland by the cancer cells in vivo

Autor: Matti Poutanen, Leena Strauss, Sari Mäkelä, Niina Saarinen, Päivi Järvensivu

Publikováno v: Cancer Research. 73:1402-1402

Aromatase enzyme coded by the CYP19A1 gene catalyzes the final step of estrogen biosynthesis and is of major significance in endocrine regulation of breast cancer (BCa). Human CYP19A1 gene expression is regulated through the utilization of various no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19aa18442f73bf2f478802f9fa15dd7e
https://doi.org/10.1158/1538-7445.am2013-1402

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