Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Päivi Östling"'
Autor:
Pedro Fonseca, Weiyingqi Cui, Nona Struyf, Le Tong, Ayushi Chaurasiya, Felipe Casagrande, Honglei Zhao, Dinura Fernando, Xinsong Chen, Nicholas P. Tobin, Brinton Seashore-Ludlow, Andreas Lundqvist, Johan Hartman, Anita Göndör, Päivi Östling, Lars Holmgren
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-23 (2024)
Abstract Background Tumor cells have the ability to invade and form small clusters that protrude into adjacent tissues, a phenomenon that is frequently observed at the periphery of a tumor as it expands into healthy tissues. The presence of these clu
Externí odkaz:
https://doaj.org/article/33dfb61ce30b4942b583460a044384b6
Autor:
Nona Struyf, Albin Österroos, Mattias Vesterlund, Cornelia Arnroth, Tojo James, Stephanie Sunandar, Georgios Mermelekas, Anna Bohlin, Kerstin Hamberg Levedahl, Sofia Bengtzén, Rozbeh Jafari, Lukas M. Orre, Janne Lehtiö, Sören Lehmann, Päivi Östling, Olli Kallioniemi, Brinton Seashore-Ludlow, Tom Erkers
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-7 (2024)
Abstract Consistent handling of samples is crucial for achieving reproducible molecular and functional testing results in translational research. Here, we used 229 acute myeloid leukemia (AML) patient samples to assess the impact of sample handling o
Externí odkaz:
https://doaj.org/article/b137e1c0bbc24a2a9826fbbf5bd104d4
Autor:
Ahlem Zaghmi, Erdem Aybay, Long Jiang, Mingmei Shang, Julia Steinmetz‐Späh, Fredrik Wermeling, Per Kogner, Marina Korotkova, Päivi Östling, Per‐Johan Jakobsson, Brinton Seashore‐Ludlow, Karin Larsson
Publikováno v:
Molecular Oncology, Vol 18, Iss 2, Pp 317-335 (2024)
High‐throughput drug screening enables the discovery of new anticancer drugs. Although monolayer cell cultures are commonly used for screening, their limited complexity and translational efficiency require alternative models. Three‐dimensional ce
Externí odkaz:
https://doaj.org/article/4a29d39e06f844be8b5afb223e6cda70
Autor:
Emma Åkerlund, Greta Gudoityte, Elisabeth Moussaud-Lamodière, Olina Lind, Henri Colyn Bwanika, Kaisa Lehti, Sahar Salehi, Joseph Carlson, Emelie Wallin, Josefin Fernebro, Päivi Östling, Olli Kallioniemi, Ulrika Joneborg, Brinton Seashore-Ludlow
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-13 (2023)
Abstract Most patients with advanced ovarian cancer (OC) relapse and progress despite systemic therapy, pointing to the need for improved and tailored therapy options. Functional precision medicine can help to identify effective therapies for individ
Externí odkaz:
https://doaj.org/article/f9a11623e752413883774ad582a47d05
Autor:
Quang Thinh Trac, Yudi Pawitan, Tian Mou, Tom Erkers, Päivi Östling, Anna Bohlin, Albin Österroos, Mattias Vesterlund, Rozbeh Jafari, Ioannis Siavelis, Helena Bäckvall, Santeri Kiviluoto, Lukas M. Orre, Mattias Rantalainen, Janne Lehtiö, Sören Lehmann, Olli Kallioniemi, Trung Nghia Vu
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-10 (2023)
Abstract Despite some encouraging successes, predicting the therapy response of acute myeloid leukemia (AML) patients remains highly challenging due to tumor heterogeneity. Here we aim to develop and validate MDREAM, a robust ensemble-based predictio
Externí odkaz:
https://doaj.org/article/708587f7449c4c56ba44998f3046d58f
Autor:
Isabelle Rose Leo, Luay Aswad, Matthias Stahl, Elena Kunold, Frederik Post, Tom Erkers, Nona Struyf, Georgios Mermelekas, Rubin Narayan Joshi, Eva Gracia-Villacampa, Päivi Östling, Olli P. Kallioniemi, Katja Pokrovskaja Tamm, Ioannis Siavelis, Janne Lehtiö, Mattias Vesterlund, Rozbeh Jafari
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Childhood acute lymphoblastic leukemia is characterised by a range of genetic aberrations. Here, the authors use multi-omics profiling of ALL cell lines to connect molecular phenotypes and drug responses to provide an interactive resource of drug sen
Externí odkaz:
https://doaj.org/article/9c69031e6a7f4af09b4fad9d64e4c2b5
Autor:
Martin Jädersten, Ingrid Lilienthal, Nikolaos Tsesmetzis, Magda Lourda, Sofia Bengtzén, Anna Bohlin, Cornelia Arnroth, Tom Erkers, Brinton Seashore‐Ludlow, Géraldine Giraud, Giti S. Barkhordar, Sijia Tao, Linda Fogelstrand, Leonie Saft, Päivi Östling, Raymond F. Schinazi, Baek Kim, Torsten Schaller, Gunnar Juliusson, Stefan Deneberg, Sören Lehmann, Georgios Z. Rassidakis, Martin Höglund, Jan‐Inge Henter, Nikolas Herold
Publikováno v:
Journal of Internal Medicine. 292:925-940
Background Treatment of newly diagnosed acute myeloid leukaemia (AML) is based on combination chemotherapy with cytarabine (ara-C) and anthracyclines. Five-year overall survival is below 30%, which has partly been attributed to cytarabine resistance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7262903736bd9309cb6acda89412cf76
https://doi.org/10.1111/joim.13553
https://doi.org/10.1111/joim.13553
Autor:
Tove Wästerlid, Lucia Cavelier, Claudia Haferlach, Marina Konopleva, Stefan Fröhling, Päivi Östling, Lars Bullinger, Thoas Fioretos, Karin E. Smedby
Publikováno v:
Journal of Internal Medicine. 292:243-261
Precision medicine is revolutionising patient care in cancer. As more knowledge is gained about the impact of specific genetic lesions on diagnosis, prognosis and treatment response, diagnostic precision and the possibility for optimal individual tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0c2b2c8372888f13ade0e2934e1d9c
https://doi.org/10.1111/joim.13508
https://doi.org/10.1111/joim.13508
Autor:
Swapnil Potdar, Filipp Ianevski, Aleksandr Ianevski, Ziaurrehman Tanoli, Krister Wennerberg, Brinton Seashore-Ludlow, Olli Kallioniemi, Päivi Östling, Tero Aittokallio, Jani Saarela
Publikováno v:
Nucleic Acids Research.
Functional precision medicine (fPM) offers an exciting, simplified approach to finding the right applications for existing molecules and enhancing therapeutic potential. Integrative and robust tools ensuring high accuracy and reliability of the resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5415e3aac4132f0e8b61d59fc6d69a5b
https://doi.org/10.1093/nar/gkad390
https://doi.org/10.1093/nar/gkad390
Autor:
Ulrika Warpman Berglund, Thomas Helleday, Julian Walfridsson, Päivi Östling, Mathew J. Garnett, Kim Theilgaard-Mönch, Sören Lehmann, Teresa Sandvall, Olov Wallner, Martin Henriksson, Tobias Koolmeister, Martin Scobie, Torkild Visnes, Nona Struyf, Thea Kristin Våtsveen, Montserrat Estruch, Anders Centio, Stefanie Friedrich, Azita Rasti, Camilla Göktürk, Elisee Wiita, Helge Gad, Akhilesh Nagesh Danda, Brinton Seashore-Ludlow, Yaser Heshmati, Andreas Höglund, Ingrid Almlöf, Viktoriia Tsuber, Tom Erkers, Therese M. Pham, José Manuel Calderón-Montaño, Kumar Sanjiv
Supplementary figures and tables and material and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1280d78da8fe2c0fa692e2c21f2cc0ef
https://doi.org/10.1158/0008-5472.22490525
https://doi.org/10.1158/0008-5472.22490525
