Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Päivi Äänismaa"'
Autor:
Emmanuel A. Meyer, Päivi Äänismaa, Eric A. Ertel, Eva Hühn, Daniel S. Strasser, Markus Rey, Mark J. Murphy, Marianne M. Martinic, Laetitia Pouzol, Sylvie Froidevaux, Marcel P. Keller, Eva Caroff
Publikováno v:
Journal of Medicinal Chemistry. 66:4179-4196
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7df504f393165b1ded7be41f0a7150f
https://doi.org/10.1021/acs.jmedchem.3c00074
https://doi.org/10.1021/acs.jmedchem.3c00074
Publikováno v:
Journal of Medicinal Chemistry. 65:11533-11549
The chemokine receptor CXCR3 allows the selective recruitment of innate and adaptive inflammatory immune cells into inflamed tissue. CXCR3 ligands are secreted after exposure to pro-inflammatory cytokines. Upon binding to CXCR3 ligands, CXCR3 express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90f09542dd97c80892db80d69bfcf7b
https://doi.org/10.1021/acs.jmedchem.2c00676
https://doi.org/10.1021/acs.jmedchem.2c00676
Publikováno v:
Journal of Medicinal Chemistry. 65:11513-11532
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41fc55d964ee971478ede9a5e0c6b845
https://doi.org/10.1021/acs.jmedchem.2c00675
https://doi.org/10.1021/acs.jmedchem.2c00675
Autor:
Emmanuel A, Meyer, Päivi, Äänismaa, Sylvie, Froidevaux, Marcel, Keller, Luca, Piali, Eva, Caroff
Publikováno v:
Journal of medicinal chemistry. 65(17)
The chemokine receptor CXCR3 is a seven-transmembrane G-protein-coupled receptor (GPCR) involved in various pathologies, in particular autoimmune diseases. It is activated by the three chemokine ligands CXCL9, CXCL10, and CXCL11 and enables the recru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6d83fda98a6de4d714585d8f1db0f4c4
https://pubmed.ncbi.nlm.nih.gov/35947786
https://pubmed.ncbi.nlm.nih.gov/35947786
Autor:
Päivi Äänismaa, Jérôme Segrestaa, Jasper Dingemanse, Séverine Niglis, Priska Kaufmann, Atef Halabi, Shirin Bruderer
Publikováno v:
British Journal of Clinical Pharmacology. 80:670-677
Aims This study investigated the effect of a fixed dose combination of lopinavir/ritonavir on the pharmacokinetics (PK) of selexipag and its active metabolite ACT-333679. Methods This was an open label, randomized, single centre, two way, crossover s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c94ad92c264e505799fce5d5a94ee913
https://doi.org/10.1111/bcp.12650
https://doi.org/10.1111/bcp.12650
Autor:
Alexander Treiber, Swen Seeland, Tomohiko Ichikawa, Tetsuhiro Yamada, Päivi Äänismaa, Stephane Delahaye, Carmela Gnerre, Ruben de Kanter, Thomas Pfeifer, Jérôme Segrestaa
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 48(7)
1. The metabolism of selexipag has been studied in vivo in man and the main excreted metabolites were identified. Also, metabolites circulating in human plasma have been structurally identified and quantified. 2. The main metabolic pathway of selexip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0914760012925198a0329ac8a3bf9a1e
https://pubmed.ncbi.nlm.nih.gov/28737453
https://pubmed.ncbi.nlm.nih.gov/28737453
Autor:
Patrick Hess, Marianne Treher, Stephane Delahaye, Patricia N. Sidharta, Ruben de Kanter, Alexander Treiber, Päivi Äänismaa
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 350:130-143
Treatment of pulmonary arterial hypertension with the endothelin receptor antagonist bosentan has been associated with transient increases in liver transaminases. Mechanistically, bosentan inhibits the bile salt export pump (BSEP) leading to an intra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580427d35eee633c9fa1edca668ad933
https://doi.org/10.1124/jpet.114.214106
https://doi.org/10.1124/jpet.114.214106
Autor:
Anna Seelig, Kaspar P. Locher, Xiaochun Li-Blatter, Roger J. P. Dawson, Andreas Beck, Päivi Äänismaa
Publikováno v:
Biochemistry
The ATP-binding cassette exporters Sav1866 from Staphylococcus aureus and P-glycoprotein are known to share a certain sequence similarity and disposition for cationic allocrites. Conversely, the two ATPases react very differently to neutral detergent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff6cd1cd5122f3e8d633b73a48b2196
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1798:515-525
We compared the P-glycoprotein ATPase activity in inside–out plasma membrane vesicles and living NIH-MDR1-G185 cells with the aim to detect substrate transport. To this purpose we used six substrates which differ significantly in their passive infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff706aab1597d875bf7afad57c456f2a
https://doi.org/10.1016/j.bbamem.2009.11.022
https://doi.org/10.1016/j.bbamem.2009.11.022
Autor:
Anna Seelig, Päivi Äänismaa
Publikováno v:
Biochemistry. 46:3394-3404
P-glycoprotein (MDR1, ABCB1) is an ATP-dependent efflux transporter of a large variety of compounds. To understand P-glycoprotein in more detail, it is important to elucidate its activity in the cellular ensemble as well as in plasma membrane vesicle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c7b1b06f2fb105038f6db76c83a32c
https://doi.org/10.1021/bi0619526
https://doi.org/10.1021/bi0619526