Výsledky vyhledávání - "Páraic M. Keane"

Time-resolved infra-red studies of photo-excited porphyrins in the presence of nucleic acids and in HeLa tumour cells: insights into binding site and electron transfer dynamics

Autor: Páraic M. Keane, Clara Zehe, Fergus E. Poynton, Sandra A. Bright, Sandra Estayalo-Adrián, Stephen J. Devereux, Paul M. Donaldson, Igor V. Sazanovich, Michael Towrie, Stanley W. Botchway, Christine J. Cardin, D. Clive Williams, Thorfinnur Gunnlaugsson, Conor Long, John M. Kelly, Susan J. Quinn

Publikováno v: Physical Chemistry Chemical Physics. 24:27524-27531

Time-resolved IR spectra of porphyrins bound to biomolecules are reported. DFT calculations aid porphyrin vibration assignment while distinctive IR bands reveal interactions with therapeutic targets such as quadruplex DNA and proteins in HeLa cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a0ee54e310a305a49a908f369ebd7f
https://doi.org/10.1039/d2cp04604k

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Transient absorption and time-resolved vibrational studies of photophysical and photochemical processes in DNA-intercalating polypyridyl metal complexes or cationic porphyrins

Autor: John M. Kelly, Páraic M. Keane

Publikováno v: Coordination Chemistry Reviews. 364:137-154

Recent advances in the use of transient absorption (TA) and time-resolved vibrational spectroscopies (TRIR and TR3) to study both excited states and reaction intermediates in metal complexes and porphyrins which intercalate into DNA are reviewed. A p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b8f6cd5b27eb0deeb16d908970c26ea
https://doi.org/10.1016/j.ccr.2018.02.018

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Inosine Can Increase DNA′s Susceptibility to Photo‐oxidation by a RuIIComplex due to Structural Change in the Minor Groove

Autor: Christine J. Cardin, Ian P. Clark, Sarah P. Gurung, Bjørn la Cour Poulsen, Fergus E. Poynton, Michael Towrie, James P. Hall, Susan J. Quinn, Páraic M. Keane, Igor V. Sazanovich, Thorfinnur Gunnlaugsson, John M. Kelly

Publikováno v: Chemistry – A European Journal. 23:10344-10351

Weinheim Key to the development of DNA-targeting phototherapeutic drugs is determining the interplay between the photoactivity of the drug and its binding preference for a target sequence. For the photo-oxidising lambda-[Ru(TAP)2(dppz)]2+ (Λ-1) (dpp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600a7870e18f9d01de963b80d6bb1243
https://doi.org/10.1002/chem.201701447

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Spectro-electrochemical Studies on [Ru(TAP)2 (dppz)]2+ - Insights into the Mechanism of its Photosensitized Oxidation of Oligonucleotides

Autor: Conor Long, Christine J. Cardin, Páraic M. Keane, Joanne Tory, John M. Kelly, Susan J. Quinn, Michael Towrie, František Hartl, Igor V. Sazanovich

[Ru(TAP) 2 (dppz)] 2+ (TAP = 1,4,5,8-tetraazaphenanthrene; dppz = dipyrido[3,2-a:2′,3′-c]phenazine) is known to photo-oxidize guanine in DNA. Whether this oxidation proceeds by direct photoelectron transfer or by proton-coupled electron transfer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1689a7e6f1dded7a6dc82ef517b5e44

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Monitoring one-electron photo-oxidation of guanine in DNA crystals using ultrafast infrared spectroscopy

Autor: Christine J. Cardin, Fergus E. Poynton, Igor V. Sazanovich, Susan J. Quinn, David J. Cardin, Páraic M. Keane, Sarah P. Gurung, James P. Hall, John M. Kelly, Michael Towrie, John A. Brazier, Thorfinnur Gunnlaugsson, Graeme Winter

Publikováno v: Nature Chemistry. 7:961-967

To understand the molecular origins of diseases caused by ultraviolet and visible light, and also to develop photodynamic therapy, it is important to resolve the mechanism of photoinduced DNA damage. Damage to DNA bound to a photosensitizer molecule

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c87f6f09bc5d449db9a922cab3612a
https://doi.org/10.1038/nchem.2369

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Inosine Can Increase DNA's Susceptibility to Photo-oxidation by a Ru

Autor: Páraic M, Keane, James P, Hall, Fergus E, Poynton, Bjørn C, Poulsen, Sarah P, Gurung, Ian P, Clark, Igor V, Sazanovich, Michael, Towrie, Thorfinnur, Gunnlaugsson, Susan J, Quinn, Christine J, Cardin, John M, Kelly

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 23(43)

Key to the development of DNA-targeting phototherapeutic drugs is determining the interplay between the photoactivity of the drug and its binding preference for a target sequence. For the photo-oxidising lambda-[Ru(TAP)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::59461373e9a968042819bee7cc3880a3
https://pubmed.ncbi.nlm.nih.gov/28543779

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Ground and excited state interactions of metalloporphyrin PtTMPyP4 with polynucleotides [poly(dG-dC)]2 and [poly(dA-dT)]2

Autor: John M. Kelly, Páraic M. Keane

Publikováno v: Photochemicalphotobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 15(8)

The ground- and excited-state interactions of Pt(ii) meso-tetrakis(4-N-methylpyridyl)porphyrin (PtTMPyP4) with polynucleotides [poly(dG-dC)]2 and [poly(dA-dT)]2 have been investigated using UV/visible, circular dichroism, and steady-state and time-re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6f31788515debc1645a9391ffc1817
https://pubmed.ncbi.nlm.nih.gov/27377608

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