Zobrazeno 1 - 10
of 398
pro vyhledávání: '"P, Tsichlis"'
Autor:
Alessandro La Ferlita, Salvatore Alaimo, Giovanni Nigita, Rosario Distefano, Joal D. Beane, Philip N. Tsichlis, Alfredo Ferro, Carlo M. Croce, Alfredo Pulvirenti
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108810- (2024)
Summary: tRNA-derived ncRNAs are a heterogeneous class of non-coding RNAs recently proposed to be active regulators of gene expression and be involved in many diseases, including cancer. Consequently, several online resources on tRNA-derived ncRNAs h
Externí odkaz:
https://doaj.org/article/df8d8d9b250e4871b51ccf310172e060
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 350 (2024)
Neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, affect a wide variety of the population and pose significant challenges with progressive and irreversible neural cell loss. The limitations of brain-targeting therapies and the uncl
Externí odkaz:
https://doaj.org/article/7203d2cd9cca475da6517e26ca9a909c
Autor:
Apostolia-Maria Tsimberidou, Antonis Skliris, Alan Valentine, Jamie Shaw, Ursula Hering, Henry Hiep Vo, Tung On Chan, Roger S. Armen, Jeffrey R. Cottrell, Jen Q. Pan, Philip N. Tsichlis
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Background Changes in the expression and activity of the AKT oncogene play an important role in psychiatric disease. We present translational data assessing the role of AKT in psychiatric symptoms. Methods (1) We assessed the protein activit
Externí odkaz:
https://doaj.org/article/db571bc65b8444c39720d8f1d6ebe5cd
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Georgios I. Laliotis, Adam D. Kenney, Evangelia Chavdoula, Arturo Orlacchio, Abdul Kaba, Alessandro La Ferlita, Vollter Anastas, Christos Tsatsanis, Joal D. Beane, Lalit Sehgal, Vincenzo Coppola, Jacob S. Yount, Philip N. Tsichlis
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Laliotis et al. examine the role of the AKT3-phoshorylated RNA processing factor IWS1 and the IWS1 phosphorylation-dependent alternative splicing of U2AF2 in lung adenocarcinoma cells. The alternatively spliced variant of U2AF2 regulates the nuclear
Externí odkaz:
https://doaj.org/article/4976aacb26fc469e84b6096ba7b23887
Autor:
Ioannis Tsichlis, Athanasia-Paraskevi Manou, Vasiliki Manolopoulou, Konstantina Matskou, Maria Chountoulesi, Vasiliki Pletsa, Aristotelis Xenakis, Costas Demetzos
Publikováno v:
Materials, Vol 16, Iss 16, p 5509 (2023)
The aim of the present study is the development, physicochemical characterization, and in vitro cytotoxicity evaluation of both empty and quercetin-loaded HSPC (hydrogenated soy phosphatidylcholine) liposomes, GMO (glyceryl monooleate) liquid crystal
Externí odkaz:
https://doaj.org/article/41808a424c03488f85c4f755082b9e87
Autor:
Georgios I. Laliotis, Evangelia Chavdoula, Maria D. Paraskevopoulou, Abdul Kaba, Alessandro La Ferlita, Satishkumar Singh, Vollter Anastas, Keith A. Nair, Arturo Orlacchio, Vasiliki Taraslia, Ioannis Vlachos, Marina Capece, Artemis Hatzigeorgiou, Dario Palmieri, Christos Tsatsanis, Salvatore Alaimo, Lalit Sehgal, David P. Carbone, Vincenzo Coppola, Philip N. Tsichlis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-25 (2021)
IWS1 regulates multiple steps in RNA metabolism, including RNA elongation and alternative RNA splicing. Here the authors show that AKT3 phosphorylates IWS1, which alters U2AF2 RNA splicing and promotes growth of lung adenocarcinomas via a Sororin/ERK
Externí odkaz:
https://doaj.org/article/d561adaf19ee4c4ab175614033a5dedb
Autor:
Alessandro La Ferlita, Salvatore Alaimo, Sebastiano Di Bella, Emanuele Martorana, Georgios I. Laliotis, Francesco Bertoni, Luciano Cascione, Philip N. Tsichlis, Alfredo Ferro, Roberta Bosotti, Alfredo Pulvirenti
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-16 (2021)
Abstract Background RNA-Seq is a well-established technology extensively used for transcriptome profiling, allowing the analysis of coding and non-coding RNA molecules. However, this technology produces a vast amount of data requiring sophisticated c
Externí odkaz:
https://doaj.org/article/4e360b93746c4bf4a5e05628bf5e1e7a
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Akt is a PI3K-activated serine-threonine kinase that exists in three distinct isoforms. Akt’s expression in most immune cells, either at baseline or upon activation, reflects its importance in the immune system. While Akt is most highly expressed i
Externí odkaz:
https://doaj.org/article/ed1c0cae6a8e4117bb2d5e49302d3186
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.