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of 2 353
pro vyhledávání: '"P, Tansey"'
Controlling false positives (Type I errors) through statistical hypothesis testing is a foundation of modern scientific data analysis. Existing causal structure discovery algorithms either do not provide Type I error control or cannot scale to the si
Externí odkaz:
http://arxiv.org/abs/2310.16626
Autor:
Hannah A. Staley, Janna E. Jernigan, MacKenzie L. Bolen, Ann M. Titus, Noelle Neighbarger, Cassandra Cole, Kelly B. Menees, Rebecca L. Wallings, Malú Gámez Tansey
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-16 (2024)
Abstract Genome-wide association studies have identified a protective mutation in the phospholipase C gamma 2 (PLCG2) gene which confers protection against Alzheimer’s disease (AD)-associated cognitive decline. Therefore, PLCG2, which is primarily
Externí odkaz:
https://doaj.org/article/2fe3c49932fc460e96040f55471113e1
Autor:
Amy D. Harper, Haluk Topaloglu, Eugenio Mercuri, Vasiliy Suslov, Liwen Wu, Cigdem Y. Ayanoglu, Michael Tansey, Michelle L. Previtera, Robert A. Crozier, Leslie Magnus, Paula R. Clemens
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Duchenne muscular dystrophy (DMD) is an X-linked recessive disease characterized by mutations in the dystrophin gene, causing motor and pulmonary function decline. Viltolarsen is indicated for patients with dystrophin gene mutations amenable
Externí odkaz:
https://doaj.org/article/9968d3b7d6514a56bdbd3bf8f3a6e367
Autor:
Valerie Joers, Benjamin C Murray, Caroline McLaughlin, Danielle Oliver, Hannah E. Staley, Jazmyn Coronado, Cindy Achat-Mendes, Sanam Golshani, Sean D. Kelly, Matthew Goodson, Danica Lee, Fredric P. Manfredsson, Bob M. Moore II, Malú Gámez Tansey
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-20 (2024)
Abstract Research into the disequilibrium of microglial phenotypes has become an area of intense focus in neurodegenerative disease as a potential mechanism that contributes to chronic neuroinflammation and neuronal loss in Parkinson’s disease (PD)
Externí odkaz:
https://doaj.org/article/dae8f1cd186941429aefb572745115d0
Autor:
Drew A. Gillett, Noelle K. Neighbarger, Cassandra Cole, Rebecca L. Wallings, Malú Gámez Tansey
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionProgranulin (PGRN) is a holoprotein that is internalized and taken to the lysosome where it is processed to individual granulins (GRNs). PGRN is critical for successful aging, and insufficient levels of PGRN are associated with increased
Externí odkaz:
https://doaj.org/article/77f57527ae884894b213d5289290f4d1
Autor:
Priyanka Mittapelly, Kristen N. Guelly, Altaf Hussain, Héctor A. Cárcamo, Juliana J. Soroka, Meghan A. Vankosky, Dwayne D. Hegedus, James A. Tansey, Alejandro C. Costamagna, John Gavloski, Janet J. Knodel, Boyd A. Mori
Publikováno v:
GCB Bioenergy, Vol 16, Iss 9, Pp n/a-n/a (2024)
Abstract Canola (Brassica napus L. and B. rapa L. [Brassicales: Brassicaceae]) is a major oilseed crop grown globally as a source of vegetable oil, animal feed and biofuel feedstock. The global demand for canola oil as a biofuel feedstock has increas
Externí odkaz:
https://doaj.org/article/f73dd34f6fb7493b9d529ec81ab5b74d
A fundamental task in science is to design experiments that yield valuable insights about the system under study. Mathematically, these insights can be represented as a utility or risk function that shapes the value of conducting each experiment. We
Externí odkaz:
http://arxiv.org/abs/2210.12122
Autor:
Sarah A. Streeter, Alexandria G. Williams, James R. Evans, Jing Wang, Alissa D. Guarnaccia, Andrea C. Florian, Rafet Al-Tobasei, Qi Liu, William P. Tansey, April M. Weissmiller
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background During mitosis the cell depends on proper attachment and segregation of replicated chromosomes to generate two identical progeny. In cancers defined by overexpression or dysregulation of the MYC oncogene this process becomes impai
Externí odkaz:
https://doaj.org/article/073c9794a0504f28b71f32dd3bcd78ec
Conditional randomization tests (CRTs) assess whether a variable $x$ is predictive of another variable $y$, having observed covariates $z$. CRTs require fitting a large number of predictive models, which is often computationally intractable. Existing
Externí odkaz:
http://arxiv.org/abs/2208.08579
Publikováno v:
Frontiers in Rehabilitation Sciences, Vol 5 (2024)
Approved in 2014 by the Food and Drug Administration (FDA) for use with a trained companion, personal powered exoskeletons (PPE) for individuals with spinal cord injury (SCI) provide an opportunity for the appropriate candidate to ambulate in their h
Externí odkaz:
https://doaj.org/article/8c923f467f404d208c3b1de0b2cb512a