Zobrazeno 1 - 10
of 304
pro vyhledávání: '"P, Schimenti"'
Autor:
Andrea Flesken-Nikitin, Coulter Q. Ralston, Dah-Jiun Fu, Andrea J. De Micheli, Daryl J. Phuong, Blaine A. Harlan, Christopher S. Ashe, Amanda P. Armstrong, David W. McKellar, Sangeeta Ghuwalewala, Lora H. Ellenson, John C. Schimenti, Benjamin D. Cosgrove, Alexander Yu. Nikitin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The distal region of the uterine (Fallopian) tube is commonly associated with high-grade serous carcinoma (HGSC), the predominant and most aggressive form of ovarian or extra-uterine cancer. Specific cell states and lineage dynamics of the a
Externí odkaz:
https://doaj.org/article/90512a4f897946e0b160380da2b3bd0c
Autor:
Andrea Flesken-Nikitin, Coulter Q. Ralston, Dah-Jiun Fu, Andrea J. De Micheli, Daryl J. Phuong, Blaine A. Harlan, Christopher S. Ashe, Amanda P. Armstrong, David W. McKellar, Sangeeta Ghuwalewala, Lora H. Ellenson, John C. Schimenti, Benjamin D. Cosgrove, Alexander Yu. Nikitin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/c1b51fbd06f54c12965de39a855e1747
Autor:
Yu-Han Hung, Meghan Capeling, Jonathan W. Villanueva, Matt Kanke, Michael T. Shanahan, Sha Huang, Rebecca Cubitt, Vera D. Rinaldi, John C. Schimenti, Jason R. Spence, Praveen Sethupathy
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-19 (2023)
Abstract Background MicroRNAs (miRNAs) are important post-transcriptional gene regulators controlling cellular lineage specification and differentiation during embryonic development, including the gastrointestinal system. However, miRNA-mediated regu
Externí odkaz:
https://doaj.org/article/02087dfb606b46d7bd6a6a50830c592e
Akademický článek
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Autor:
Xinbao Ding, John C Schimenti
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 6, Pp 1-3 (2023)
Abstract Assisted reproduction procedures often encounter an issue called oocyte maturation arrest (OMA), which is manifested as failed IVF/ICSI attempts using oocytes from some infertile women. In this issue of EMBO Molecular Medicine, Wang et al id
Externí odkaz:
https://doaj.org/article/8a1cc6004a054f28a59a4d2175a9c14b
Autor:
Sasha L. Fulton, Wendy Wenderski, Ashley E. Lepack, Andrew L. Eagle, Tomas Fanutza, Ryan M. Bastle, Aarthi Ramakrishnan, Emma C. Hays, Arianna Neal, Jaroslav Bendl, Lorna A. Farrelly, Amni Al-Kachak, Yang Lyu, Bulent Cetin, Jennifer C. Chan, Tina N. Tran, Rachael L. Neve, Randall J. Roper, Kristen J. Brennand, Panos Roussos, John C. Schimenti, Allyson K. Friedman, Li Shen, Robert D. Blitzer, Alfred J. Robison, Gerald R. Crabtree, Ian Maze
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The molecular mechanisms underlying deficits in Down syndrome remain unclear. Here, the authors show that copy number restoration of a chromatin remodeler in trisomic mice is sufficient to rescue epigenomic, physiological and cognitive deficits.
Externí odkaz:
https://doaj.org/article/4d9fc438d0e34047a77c7e2c58308fbb
Akademický článek
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Autor:
Priti Singh, Robert Fragoza, Cecilia S. Blengini, Tina N. Tran, Gianno Pannafino, Najla Al-Sweel, Kerry J. Schimenti, Karen Schindler, Eric A. Alani, Haiyuan Yu, John C. Schimenti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Proper meiotic chromosome segregation requires mismatch repair genes MLH1 and MLH3, of which variants occur in the human population. Here, the authors use computational predictions and yeast assays to select human MLH1/3 variants for modelling in mic
Externí odkaz:
https://doaj.org/article/ea5df12e8dcb4fb3a1ae13ed6a79b628
Akademický článek
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Autor:
Pan Gao, Qing Lyu, Amr R. Ghanam, Cicera R. Lazzarotto, Gregory A. Newby, Wei Zhang, Mihyun Choi, Orazio J. Slivano, Kevin Holden, John A. Walker, Anastasia P. Kadina, Rob J. Munroe, Christian M. Abratte, John C. Schimenti, David R. Liu, Shengdar Q. Tsai, Xiaochun Long, Joseph M. Miano
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-21 (2021)
Abstract Background Most single nucleotide variants (SNVs) occur in noncoding sequence where millions of transcription factor binding sites (TFBS) reside. Here, a comparative analysis of CRISPR-mediated homology-directed repair (HDR) versus the recen
Externí odkaz:
https://doaj.org/article/3ae7242cf5e844faa32def1a4de9bd76