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Akademický článek

Oncologist-Reported Barriers and Facilitators to Offering Cancer Clinical Trials to Their Patients

Autor: Brenda S. Castillo, Leigh Boehmer, Janelle Schrag, Alexandra Howson, Randall Oyer, Lori Pierce, Nadine J. Barrett, Carmen E. Guerra

Publikováno v: Current Oncology, Vol 31, Iss 6, Pp 3017-3029 (2024)

NCCN guidelines indicate that cancer clinical trials (CCTs) are the best management for patients with cancer. However, only 5% of patients enroll in them. We examined oncologists’ perceived barriers and facilitators to discussing CCTs. This qualita

Externí odkaz: https://doaj.org/article/aa37b73a36c8471bac340642172ec816

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Akademický článek

Parainfluenza Virus 5 V Protein Blocks Interferon Gamma-Mediated Upregulation of NK Cell Inhibitory Ligands and Improves NK Cell Killing of Neuroblastoma Cells

Autor: Elisabeth M. Shiffer, Jeremiah L. Oyer, Alicja J. Copik, Griffith D. Parks

Publikováno v: Viruses, Vol 16, Iss 8, p 1270 (2024)

Natural killer (NK) cells can be effective immunotherapeutic anti-cancer agents due to their ability to selectively target and kill tumor cells. This activity is modulated by the interaction of NK cell receptors with inhibitory ligands on the surface

Externí odkaz: https://doaj.org/article/5d77f5493d7548818ab809e97de35206

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Akademický článek

PM21-particle stimulation augmented with cytokines enhances NK cell expansion and confers memory-like characteristics with enhanced survival

Autor: Jeremiah L. Oyer, Tayler J. Croom-Perez, Md Faqrul Hasan, Javier A. Rivera-Huertas, Sarah B. Gitto, Joanna M. Mucha, Xiang Zhu, Deborah A. Altomare, Robert Y. Igarashi, Alicja J. Copik

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

NK cell therapeutics have gained significant attention as a potential cancer treatment. Towards therapeutic use, NK cells need to be activated and expanded to attain high potency and large quantities for an effective dosage. This is typically done by

Externí odkaz: https://doaj.org/article/a1322c48c6044a24a3fa333918436d9b

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Akademický článek

A quantitative analysis of Twitter ('X') trends in the discussion of rhinoplasty

Autor: Shreya Mandava, Samuel L. Oyer, Stephen S. Park

Publikováno v: Laryngoscope Investigative Otolaryngology, Vol 9, Iss 1, Pp n/a-n/a (2024)

Abstract Introduction Rhinoplasty is one of the most common cosmetic surgical procedures performed globally. Twitter, also known as “X,” is used by both patients and physicians and has been studied as a useful tool for analyzing trends in healthc

Externí odkaz: https://doaj.org/article/ee23ba1a09e643e29af326adb94dff59

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Akademický článek

Knockout of the inhibitory receptor TIGIT enhances the antitumor response of ex vivo expanded NK cells and prevents fratricide with therapeutic Fc-active TIGIT antibodies

Autor: Dean A Lee, Jeremiah L Oyer, Md Faqrul Hasan, Tayler J Croom-Perez, Liza D Robles-Carrillo, Sanjana Kumar, Brendan W Andersen, Brian P Tullius, Alicja J Copik, Amanda R Campbell, Thomas A Dieffenthaller, Catherine A Cash, Jonathan E Eloriaga, Meisam Naeimi Kararoudi

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 12 (2023)

Background Inhibitory receptor T-cell Immunoreceptor with Ig and ITIM domains (TIGIT) expressed by Natural Killer (NK) and T cells regulates cancer immunity and has been touted as the next frontier in the development of cancer immunotherapeutics. Alt

Externí odkaz: https://doaj.org/article/4c6550d3cfe540f09ffbff19f9a789fa

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