Výsledky vyhledávání - "P, Komalavilas"

Akademický článek

Neutrophil trafficking to the site of infection requires Cpt1a-dependent fatty acid β-oxidation

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)

Cpt1a-dependent fatty acid beta-oxidation is found to regulate neutrophil trafficking to the site of infection in a mouse model of pneumonia and is found to play a role in pneumonia susceptibility in humans.

Externí odkaz: https://doaj.org/article/d76a7386c54d4c2f854b839fc40b5550

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Blocking P2X7 receptor with AZ 10606120 exacerbates vascular hyperpermeability and inflammation in murine polymicrobial sepsis

Autor: Jamie E. Meegan, Padmini Komalavilas, Joyce Cheung‐Flynn, Tsz Wing Yim, Nathan D. Putz, Jordan J. Jesse, Kyle D. Smith, Tatiana N. Sidorova, Han Noo Ri Lee, Toria Tomasek, Ciara M. Shaver, Lorraine B. Ware, Colleen M. Brophy, Julie A. Bastarache

Publikováno v: Physiological Reports, Vol 10, Iss 11, Pp n/a-n/a (2022)

Abstract Sepsis is a devastating disease with high morbidity and mortality and no specific treatments. The pathophysiology of sepsis involves a hyperinflammatory response and release of damage‐associated molecular patterns (DAMPs), including adenos

Externí odkaz: https://doaj.org/article/c442a96d140a4867a2a4fce0591bff3d

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Cell-free hemoglobin increases inflammation, lung apoptosis, and microvascular permeability in murine polymicrobial sepsis.

Autor: Jamie E Meegan, Ciara M Shaver, Nathan D Putz, Jordan J Jesse, Stuart R Landstreet, Han Noo Ri Lee, Tatiana N Sidorova, J Brennan McNeil, James L Wynn, Joyce Cheung-Flynn, Padmini Komalavilas, Colleen M Brophy, Lorraine B Ware, Julie A Bastarache

Publikováno v: PLoS ONE, Vol 15, Iss 2, p e0228727 (2020)

Increased endothelial permeability is central to the pathogenesis of sepsis and leads to organ dysfunction and death but the endogenous mechanisms that drive increased endothelial permeability are not completely understood. We previously reported tha

Externí odkaz: https://doaj.org/article/e068d1cb04d84396b01306e30f41f480

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Normal Saline solutions cause endothelial dysfunction through loss of membrane integrity, ATP release, and inflammatory responses mediated by P2X7R/p38 MAPK/MK2 signaling pathways.

Autor: Joyce Cheung-Flynn, Bret D Alvis, Kyle M Hocking, Christy M Guth, Weifeng Luo, Reid McCallister, Kalyan Chadalavada, Monica Polcz, Padmini Komalavilas, Colleen M Brophy

Publikováno v: PLoS ONE, Vol 14, Iss 8, p e0220893 (2019)

Resuscitation with 0.9% Normal Saline (NS), a non-buffered acidic solution, leads to increased morbidity and mortality in the critically ill. The goal of this study was to determine the molecular mechanisms of endothelial injury after exposure to NS.

Externí odkaz: https://doaj.org/article/78435475be7d420db703e78bcbdcb4c9

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Vascular surgical stretch injury leads to activation of P2X7 receptors and impaired endothelial function.

Autor: Padmini Komalavilas, Weifeng Luo, Christy M Guth, Olukemi Jolayemi, Rachel I Bartelson, Joyce Cheung-Flynn, Colleen M Brophy

Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0188069 (2017)

A viable vascular endothelial layer prevents vasomotor dysfunction, thrombosis, inflammation, and intimal hyperplasia. Injury to the endothelium occurs during harvest and "back table" preparation of human saphenous vein prior to implantation as an ar

Externí odkaz: https://doaj.org/article/367a56309adf4bba9ee9f3328d1a4676

Zobrazit plný text záznamu

Akademický článek

Papaverine Prevents Vasospasm by Regulation of Myosin Light Chain Phosphorylation and Actin Polymerization in Human Saphenous Vein.

Autor: Kyle M Hocking, Gowthami Putumbaka, Eric S Wise, Joyce Cheung-Flynn, Colleen M Brophy, Padmini Komalavilas

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0154460 (2016)

OBJECTIVE:Papaverine is used to prevent vasospasm in human saphenous veins (HSV) during vein graft preparation prior to implantation as a bypass conduit. Papaverine is a nonspecific inhibitor of phosphodiesterases, leading to increases in both intrac

Externí odkaz: https://doaj.org/article/e27695ad66304baeab45c9279ff15ebd

Zobrazit plný text záznamu

Akademický článek

Role of cyclic nucleotide-dependent actin cytoskeletal dynamics:Ca(2+)](i) and force suppression in forskolin-pretreated porcine coronary arteries.

Autor: Kyle M Hocking, Franz J Baudenbacher, Gowthami Putumbaka, Sneha Venkatraman, Joyce Cheung-Flynn, Colleen M Brophy, Padmini Komalavilas

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e60986 (2013)

Initiation of force generation during vascular smooth muscle contraction involves a rise in intracellular calcium ([Ca(2+)]i) and phosphorylation of myosin light chains (MLC). However, reversal of these two processes alone does not account for the fo

Externí odkaz: https://doaj.org/article/0293527975d348ff9b9a66f998614143

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Vyhledávací nástroje:

Upřesnit hledání