Zobrazeno 1 - 10
of 25
pro vyhledávání: '"P, Hande Ozdinler"'
Autor:
P. Hande Ozdinler
Publikováno v:
Brain Sciences, Vol 14, Iss 10, p 978 (2024)
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease with progressive neurodegeneration, affecting both the cortical and the spinal component of the motor neuron circuitry in patients. The cellular and molecular basis of selective neuronal v
Externí odkaz:
https://doaj.org/article/ea65675e1a30447fad684565796e796a
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 3, Pp 725-739 (2025)
Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causi
Externí odkaz:
https://doaj.org/article/675851f1fdd04bff992f39e9eb7d15d6
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Mitochondrial defects result in dysregulation of metabolomics and energy homeostasis that are detected in upper motor neurons (UMNs) with TDP-43 pathology, a pathology that is predominantly present in both familial and sporadic cases of amyo
Externí odkaz:
https://doaj.org/article/f6559ee45b4545dcae417a9feab81be9
Autor:
Barış Genç, Mukesh Gautam, Benjamin R. Helmold, Nuran Koçak, Aksu Günay, Gashaw M. Goshu, Richard B. Silverman, P. Hande Ozdinler
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Even though amyotrophic lateral sclerosis (ALS) is a disease of the upper and lower motor neurons, to date none of the compounds in clinical trials have been tested for improving the health of diseased upper motor neurons (UMNs). There is an
Externí odkaz:
https://doaj.org/article/1615426b1cc142ffaf71653ae54dfb5a
Autor:
Javier H. Jara, Patrick L. Sheets, Maximiliano José Nigro, Mina Perić, Carolyn Brooks, Daniel B. Heller, Marco Martina, Pavle R. Andjus, P. Hande Ozdinler
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
The brain is complex and heterogeneous. Even though numerous independent studies indicate cortical hyperexcitability as a potential contributor to amyotrophic lateral sclerosis (ALS) pathology, the mechanisms that are responsible for upper motor neur
Externí odkaz:
https://doaj.org/article/8edc9ade542c4cce8a4e59e8142721fd
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Mitochondrial dysfunction is one of the converging paths for many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), and TDP-43 pathology is the most common proteinopathy detected in ALS and ALS/Frontotemporal lobar degenerati
Externí odkaz:
https://doaj.org/article/4b3cda27690a4587b9e8708b5584eb9b
Publikováno v:
Brain Sciences, Vol 11, Iss 5, p 578 (2021)
Hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS) are rare motor neuron diseases, which affect mostly the upper motor neurons (UMNs) in patients. The UMNs display early vulnerability and progressive degeneration, while other cor
Externí odkaz:
https://doaj.org/article/1adf1f94e64647c98c30ceb5f3da2b6c
Publikováno v:
Cells, Vol 9, Iss 2, p 502 (2020)
Understanding the cellular and molecular basis of selective vulnerability has been challenging, especially for motor neuron diseases. Developing drugs that improve the health of neurons that display selective vulnerability relies on in vivo cell-base
Externí odkaz:
https://doaj.org/article/2fff28d4bc034e88985efb9a06fb6151
Autor:
Oleksandr Kirsanov, Taylor Johnson, Taylor Malachowski, Bryan A. Niedenberger, Emma A. Gilbert, Debajit Bhowmick, P. Hande Ozdinler, Douglas A. Gray, Kelsey Fisher-Wellman, Brian P. Hermann, Christopher B. Geyer
Publikováno v:
Development. 149
In mammalian testes, premeiotic spermatogonia respond to retinoic acid by completing an essential lengthy differentiation program before initiating meiosis. The molecular and cellular changes directing these developmental processes remain largely und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c72bd037ab8ed9cf8894ddb1fdffba0
https://doi.org/10.1242/dev.200713
https://doi.org/10.1242/dev.200713
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 16, p 3848 (2019)
Motor neuron circuitry is one of the most elaborate circuitries in our body, which ensures voluntary and skilled movement that requires cognitive input. Therefore, both the cortex and the spinal cord are involved. The cortex has special importance fo
Externí odkaz:
https://doaj.org/article/9253b85205894ba0a2dc02e2ed476e7a