Neuroblastoma plasticity during metastatic progression stems from the dynamics of an early sympathetic transcriptomic trajectory

Autor: Benjamin Villalard, Arjan Boltjes, Florie Reynaud, Olivier Imbaud, Karine Thoinet, Ilse Timmerman, Séverine Croze, Emy Theoulle, Gianluigi Atzeni, Joël Lachuer, Jan J. Molenaar, Godelieve A. M. Tytgat, Céline Delloye-Bourgeois, Valérie Castellani

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract Despite their indisputable importance in neuroblastoma (NB) pathology, knowledge of the bases of NB plasticity and heterogeneity remains incomplete. They may be rooted in developmental trajectories of their lineage of origin, the sympatho-ad

Externí odkaz: https://doaj.org/article/8eeee38574194e8a84bc12301a8a48bf

PopulAtion Parameter Averaging (PAPA)

Autor: Jolicoeur-Martineau, Alexia, Gervais, Emy, Fatras, Kilian, Zhang, Yan, Lacoste-Julien, Simon

Ensemble methods combine the predictions of multiple models to improve performance, but they require significantly higher computation costs at inference time. To avoid these costs, multiple neural networks can be combined into one by averaging their

Externí odkaz: http://arxiv.org/abs/2304.03094

Motor innervation directs the correct development of the mouse sympathetic nervous system

Autor: Alek G. Erickson, Alessia Motta, Maria Eleni Kastriti, Steven Edwards, Fanny Coulpier, Emy Théoulle, Aliia Murtazina, Irina Poverennaya, Daniel Wies, Jeremy Ganofsky, Giovanni Canu, Francois Lallemend, Piotr Topilko, Saida Hadjab, Kaj Fried, Christiana Ruhrberg, Quenten Schwarz, Valerie Castellani, Dario Bonanomi, Igor Adameyko

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract The sympathetic nervous system controls bodily functions including vascular tone, cardiac rhythm, and the “fight-or-flight response”. Sympathetic chain ganglia develop in parallel with preganglionic motor nerves extending from the neural

Externí odkaz: https://doaj.org/article/98641f2716d646a285c21ce889f6b686

The Relationship Between Motivation And Nurse Compliance In The Use Of Personal Protective Equipment In The Internal Medicine Room Of Blambangan Hospital Banyuwangi

Autor: Diana kusumawati, Sholihin Sholihin, Rani Diana Balqis, Emy Indriyani

Publikováno v: Professional Health Journal, Vol 6, Iss 1, Pp 327-335 (2024)

Introduction : Disease transmission can be at risk for all health workers if during the action the patient does not pay attention to preventive measures by using PPE. The application of the use of personal protective equipment that is not optimal can

Externí odkaz: https://doaj.org/article/76afdfc6221947f6b45941c95ef02cc6

GPT-4 Technical Report

Autor: OpenAI, Achiam, Josh, Adler, Steven, Agarwal, Sandhini, Ahmad, Lama, Akkaya, Ilge, Aleman, Florencia Leoni, Almeida, Diogo, Altenschmidt, Janko, Altman, Sam, Anadkat, Shyamal, Avila, Red, Babuschkin, Igor, Balaji, Suchir, Balcom, Valerie, Baltescu, Paul, Bao, Haiming, Bavarian, Mohammad, Belgum, Jeff, Bello, Irwan, Berdine, Jake, Bernadett-Shapiro, Gabriel, Berner, Christopher, Bogdonoff, Lenny, Boiko, Oleg, Boyd, Madelaine, Brakman, Anna-Luisa, Brockman, Greg, Brooks, Tim, Brundage, Miles, Button, Kevin, Cai, Trevor, Campbell, Rosie, Cann, Andrew, Carey, Brittany, Carlson, Chelsea, Carmichael, Rory, Chan, Brooke, Chang, Che, Chantzis, Fotis, Chen, Derek, Chen, Sully, Chen, Ruby, Chen, Jason, Chen, Mark, Chess, Ben, Cho, Chester, Chu, Casey, Chung, Hyung Won, Cummings, Dave, Currier, Jeremiah, Dai, Yunxing, Decareaux, Cory, Degry, Thomas, Deutsch, Noah, Deville, Damien, Dhar, Arka, Dohan, David, Dowling, Steve, Dunning, Sheila, Ecoffet, Adrien, Eleti, Atty, Eloundou, Tyna, Farhi, David, Fedus, Liam, Felix, Niko, Fishman, Simón Posada, Forte, Juston, Fulford, Isabella, Gao, Leo, Georges, Elie, Gibson, Christian, Goel, Vik, Gogineni, Tarun, Goh, Gabriel, Gontijo-Lopes, Rapha, Gordon, Jonathan, Grafstein, Morgan, Gray, Scott, Greene, Ryan, Gross, Joshua, Gu, Shixiang Shane, Guo, Yufei, Hallacy, Chris, Han, Jesse, Harris, Jeff, He, Yuchen, Heaton, Mike, Heidecke, Johannes, Hesse, Chris, Hickey, Alan, Hickey, Wade, Hoeschele, Peter, Houghton, Brandon, Hsu, Kenny, Hu, Shengli, Hu, Xin, Huizinga, Joost, Jain, Shantanu, Jain, Shawn, Jang, Joanne, Jiang, Angela, Jiang, Roger, Jin, Haozhun, Jin, Denny, Jomoto, Shino, Jonn, Billie, Jun, Heewoo, Kaftan, Tomer, Kaiser, Łukasz, Kamali, Ali, Kanitscheider, Ingmar, Keskar, Nitish Shirish, Khan, Tabarak, Kilpatrick, Logan, Kim, Jong Wook, Kim, Christina, Kim, Yongjik, Kirchner, Jan Hendrik, Kiros, Jamie, Knight, Matt, Kokotajlo, Daniel, Kondraciuk, Łukasz, Kondrich, Andrew, Konstantinidis, Aris, Kosic, Kyle, Krueger, Gretchen, Kuo, Vishal, Lampe, Michael, Lan, Ikai, Lee, Teddy, Leike, Jan, Leung, Jade, Levy, Daniel, Li, Chak Ming, Lim, Rachel, Lin, Molly, Lin, Stephanie, Litwin, Mateusz, Lopez, Theresa, Lowe, Ryan, Lue, Patricia, Makanju, Anna, Malfacini, Kim, Manning, Sam, Markov, Todor, Markovski, Yaniv, Martin, Bianca, Mayer, Katie, Mayne, Andrew, McGrew, Bob, McKinney, Scott Mayer, McLeavey, Christine, McMillan, Paul, McNeil, Jake, Medina, David, Mehta, Aalok, Menick, Jacob, Metz, Luke, Mishchenko, Andrey, Mishkin, Pamela, Monaco, Vinnie, Morikawa, Evan, Mossing, Daniel, Mu, Tong, Murati, Mira, Murk, Oleg, Mély, David, Nair, Ashvin, Nakano, Reiichiro, Nayak, Rajeev, Neelakantan, Arvind, Ngo, Richard, Noh, Hyeonwoo, Ouyang, Long, O'Keefe, Cullen, Pachocki, Jakub, Paino, Alex, Palermo, Joe, Pantuliano, Ashley, Parascandolo, Giambattista, Parish, Joel, Parparita, Emy, Passos, Alex, Pavlov, Mikhail, Peng, Andrew, Perelman, Adam, Peres, Filipe de Avila Belbute, Petrov, Michael, Pinto, Henrique Ponde de Oliveira, Michael, Pokorny, Pokrass, Michelle, Pong, Vitchyr H., Powell, Tolly, Power, Alethea, Power, Boris, Proehl, Elizabeth, Puri, Raul, Radford, Alec, Rae, Jack, Ramesh, Aditya, Raymond, Cameron, Real, Francis, Rimbach, Kendra, Ross, Carl, Rotsted, Bob, Roussez, Henri, Ryder, Nick, Saltarelli, Mario, Sanders, Ted, Santurkar, Shibani, Sastry, Girish, Schmidt, Heather, Schnurr, David, Schulman, John, Selsam, Daniel, Sheppard, Kyla, Sherbakov, Toki, Shieh, Jessica, Shoker, Sarah, Shyam, Pranav, Sidor, Szymon, Sigler, Eric, Simens, Maddie, Sitkin, Jordan, Slama, Katarina, Sohl, Ian, Sokolowsky, Benjamin, Song, Yang, Staudacher, Natalie, Such, Felipe Petroski, Summers, Natalie, Sutskever, Ilya, Tang, Jie, Tezak, Nikolas, Thompson, Madeleine B., Tillet, Phil, Tootoonchian, Amin, Tseng, Elizabeth, Tuggle, Preston, Turley, Nick, Tworek, Jerry, Uribe, Juan Felipe Cerón, Vallone, Andrea, Vijayvergiya, Arun, Voss, Chelsea, Wainwright, Carroll, Wang, Justin Jay, Wang, Alvin, Wang, Ben, Ward, Jonathan, Wei, Jason, Weinmann, CJ, Welihinda, Akila, Welinder, Peter, Weng, Jiayi, Weng, Lilian, Wiethoff, Matt, Willner, Dave, Winter, Clemens, Wolrich, Samuel, Wong, Hannah, Workman, Lauren, Wu, Sherwin, Wu, Jeff, Wu, Michael, Xiao, Kai, Xu, Tao, Yoo, Sarah, Yu, Kevin, Yuan, Qiming, Zaremba, Wojciech, Zellers, Rowan, Zhang, Chong, Zhang, Marvin, Zhao, Shengjia, Zheng, Tianhao, Zhuang, Juntang, Zhuk, William, Zoph, Barret

We report the development of GPT-4, a large-scale, multimodal model which can accept image and text inputs and produce text outputs. While less capable than humans in many real-world scenarios, GPT-4 exhibits human-level performance on various profes

Externí odkaz: http://arxiv.org/abs/2303.08774