Zobrazeno 1 - 10
of 471
pro vyhledávání: '"P, Boknik"'
Autor:
von Papp, Konstanze
Publikováno v:
Common Market Law Review; June 2022, Vol. 59 Issue: 3 p950-951, 2p
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
This review presents an overview of cardiac A2A-adenosine receptors The localization of A2A-AR in the various cell types that encompass the heart and the role they play in force regulation in various mammalian species are depicted. The putative signa
Externí odkaz:
https://doaj.org/article/7431e039c5564fcea45246f2a5a97ef1
Autor:
Paula Bollmann, Franziska Werner, Marko Jaron, Tom A. Bruns, Hartmut Wache, Jochen Runte, Peter Boknik, Uwe Kirchhefer, Frank U. Müller, Igor B. Buchwalow, Sven Rothemund, Joachim Neumann, Ulrich Gergs
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
As part of our ongoing studies on the potential pathophysiological role of serine/threonine phosphatases (PP) in the mammalian heart, we have generated mice with cardiac-specific overexpression of PP2Cβ (PP2C-TG) and compared them with littermate wi
Externí odkaz:
https://doaj.org/article/b021743755d641a393a09eb53a4cce6f
Autor:
Daniel Gündel, Thu Hang Lai, Sladjana Dukic-Stefanovic, Rodrigo Teodoro, Winnie Deuther-Conrad, Magali Toussaint, Klaus Kopka, Rareş-Petru Moldovan, Peter Boknik, Britt Hofmann, Ulrich Gergs, Joachim Neumann, Peter Brust
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1025 (2022)
A2A adenosine receptors (A2A-AR) have a cardio-protective function upon ischemia and reperfusion, but on the other hand, their stimulation could lead to arrhythmias. Our aim was to investigate the potential use of the PET radiotracer [18F]FLUDA to no
Externí odkaz:
https://doaj.org/article/1b6e339ed8414db8b061627eb8e174fb
Autor:
Judith Krysiak, Andreas Unger, Lisa Beckendorf, Nazha Hamdani, Marion von Frieling-Salewsky, Margaret M. Redfield, Cris G. dos Remedios, Farah Sheikh, Ulrich Gergs, Peter Boknik, Wolfgang A. Linke
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Protein phosphatase 5 (PP5) is expressed in many cell types but its role in cardiomyocytes is unknown. Here the authors show that PP5 binds and dephosphorylates elastic titin in cardiac sarcomeres, and that PP5 is increased in heart failure, reducing
Externí odkaz:
https://doaj.org/article/cf31000b822e4204a0bb95e237b05a56
Autor:
Mara-Francine Dörner, Peter Boknik, Friedrich Köpp, Igor B. Buchwalow, Joachim Neumann, Ulrich Gergs
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9448 (2021)
As part of our ongoing studies on the potential pathophysiological role of serine/threonine phosphatases (PP) in the mammalian heart, we have generated transgenic mice with cardiac muscle cell-specific overexpression of PP2Acα (PP2A) and PP5 (PP5).
Externí odkaz:
https://doaj.org/article/5bb4384111c044dca83641d9fa5764f8
Autor:
Peter Boknik, Katharina Drzewiecki, John Eskandar, Ulrich Gergs, Britt Hofmann, Hendrik Treede, Stephanie Grote-Wessels, Larissa Fabritz, Paulus Kirchhof, Lisa Fortmüller, Frank Ulrich Müller, Wilhelm Schmitz, Norbert Zimmermann, Uwe Kirchhefer, Joachim Neumann
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Adenosine can be released from the heart and may stimulate four different cardiac adenosine receptors. A receptor subtype that couples to the generation of cyclic adenosine monophosphate (cAMP) is the A2A-adenosine receptor (A2A-AR). To better unders
Externí odkaz:
https://doaj.org/article/0c463ba0156a452cb2df32c1c35d4978
Autor:
Peter Boknik, Katharina Drzewiecki, John Eskandar, Ulrich Gergs, Stephanie Grote-Wessels, Larissa Fabritz, Paulus Kirchhof, Frank U. Müller, Frank Stümpel, Wilhelm Schmitz, Norbert Zimmermann, Uwe Kirchhefer, Joachim Neumann
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Background: Adenosine can be produced in the heart and acts on cardiac adenosine receptors. One of these receptors is the A2A-adenosine receptor (A2A-AR).Methods and Results: To better understand its role in cardiac function, we generated and charact
Externí odkaz:
https://doaj.org/article/3e1b5634a372456fa8fc49a3fe8500b4
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