Zobrazeno 1 - 10 of 110 pro vyhledávání: '"Oztekin Algul"'
1
Machine learning study: from the toxicity studies to tetrahydrocannabinol effects on Parkinson's disease
Autor: Mehmet Ali Yucel, Ibrahim Ozcelik, Oztekin Algul
Publikováno v: Future Medicinal Chemistry. 15:365-377
Aim: Investigating molecules having toxicity and chemical similarity to find hit molecules. Methods: The machine learning (ML) model was developed to predict the arylhydrocarbon receptor activity of anti-Parkinson's and US FDA-approved drugs. The ML
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::254ed85e055f89dbcd44e7c87107b01d
https://doi.org/10.4155/fmc-2022-0181
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3
Akademický článek
Design of potent fluoro-substituted chalcones as antimicrobial agents
Autor: Serdar Burmaoglu, Oztekin Algul, Arzu Gobek, Derya Aktas Anil, Mahmut Ulger, Busra Gul Erturk, Engin Kaplan, Aylin Dogen, Gönül Aslan
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 490-495 (2017)
Owing to ever-increasing bacterial and fungal drug resistance, we attempted to develop novel antitubercular and antimicrobial agents. For this purpose, we developed some new fluorine-substituted chalcone analogs (3, 4, 9–15, and 20–23) using a st
Externí odkaz: https://doaj.org/article/77706c4888f74a14bb0edeae9d7d7fb6
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4
Design, synthesis and in vitro antiproliferation activity of some 2-aryl and -heteroaryl benzoxazole derivatives
Autor: Burak Kuzu, Ceylan Hepokur, Burcin Turkmenoglu, Serdar Burmaoglu, Oztekin Algul
Publikováno v: Future Medicinal Chemistry. 14:1027-1048
Background: Phortress produces reactive electrophilic metabolites that form DNA adducts only in sensitive tumor cells. The authors converted the 2-phenylbenzothiazole nucleus in phortress to 2-aryl and -heteroaryl benzoxazole derivatives (11 new and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba1377835e262953c79acd91eec8a32
https://doi.org/10.4155/fmc-2022-0076
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5
2-Phenyl substituted Benzimidazole derivatives: Design, synthesis, and evaluation of their antiproliferative and antimicrobial activities
Autor: Ronak Haj Ersan, Burak Kuzu, Derya Yetkin, Mehmet Abdullah Alagoz, Aylin Dogen, Serdar Burmaoglu, Oztekin Algul
Publikováno v: Medicinal Chemistry Research. 31:1192-1208
The inability to meet the desired outcomes of anticancer treatment and decrease in treatment success of bacterial and fungal infections accelerated research in these areas. Our research group has conducted numerous studies, especially on benzimidazol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb70c7aee19a0fd098cc8a4948bec7f8
https://doi.org/10.1007/s00044-022-02900-3
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6
Effect of Benzimidazole Compound on Endoplasmic Reticulum Stress and Unfolded Protein Response Signaling Pathways in Hydrogen Peroxide-Induced BEAS-2B Cells
Autor: Aysel Eraslan Sakar, Meral Urhan Kucuk, Ronak Haj Ersan, Oztekin Algul
The main aim of the study was to reveal the effects of endoplasmic reticulum (ER) stress on human bronchial epithelial cells BEAS-2B at gene and protein levels under oxidative stress conditions. The second aim of the study was to investigate whether
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f954318b5f1c7f27537952894a81c947
https://doi.org/10.21203/rs.3.rs-2332298/v1
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8
Bisbenzimidazole Derivatives as Potential Antimicrobial Agents: Design, Synthesis, Biological Evaluation and Pharmacophore Analysis
Autor: Kayhan Bolelli, Serdar Burmaoglu, Serpil Gonca, Aylin Döğen, Ronak Haj Ersan, Oztekin Algul
Publikováno v: Pharmaceutical Chemistry Journal. 55:149-158
In an attempt to design and synthesize a potent class of antimicrobials, 1,2-phenylenediamine derivatives were reacted with various aliphatic and heteroaliphatic dicarboxylic acids to generate a small library of 26 head-to-head bisbenzimidazole compo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3ec1e46db4f0284925b52247887b1d2
https://doi.org/10.1007/s11094-021-02389-x
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9
Synthesis of Benzoxazole‐2‐carboxylate Derivatives: Electronic‐ and Position‐effect of Functional Groups and Computational Modeling of the Selectivity for Oxazole Ring
Autor: Burak Kuzu, Safiye Sağ Erdem, Nurettin Menges, Ozlem Sari, Oztekin Algul
Publikováno v: ChemistrySelect. 6:2529-2538
thtgerIn this study, Mitsunobu reagent, DEAD (diethyl azodicarbox-ylate) and PPh3, and ethyl-oxalamide derivatives of 2-amino-phenol were reacted under mild reaction conditions. As a resultof the cyclization reaction, benzoxazole derivatives bearing
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d305884fc33f3d8fc410f3a8d879418
https://doi.org/10.1002/slct.202100174
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10
Design, synthesis and
Autor: Burak, Kuzu, Ceylan, Hepokur, Burcin, Turkmenoglu, Serdar, Burmaoglu, Oztekin, Algul
Publikováno v: Future medicinal chemistry. 14(14)
There is an urgent need to develop potent and selective anticancer agents. In this study, the design and applications of compounds sensitive to specific cancer cells and targeting cancer cells were investigated. The results show that the synthesized
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9507e0c0ebaf80bec073e2f52322366d
https://pubmed.ncbi.nlm.nih.gov/35703122
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