Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Ozozoma Omoluabi"'
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Akademický článek
Epinephrine Activation of the β2-Adrenoceptor Is Required for IL-13-Induced Mucin Production in Human Bronchial Epithelial Cells.
Autor: Nour Al-Sawalha, Indira Pokkunuri, Ozozoma Omoluabi, Hosu Kim, Vaidehi J Thanawala, Adrian Hernandez, Richard A Bond, Brian J Knoll
Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0132559 (2015)
Mucus hypersecretion by airway epithelium is a hallmark of inflammation in allergic asthma and results in airway narrowing and obstruction. Others have shown that administration a TH2 cytokine, IL-13 is sufficient to cause mucus hypersecretion in viv
Externí odkaz: https://doaj.org/article/878dd13d12874a7e866e2d60b1e4fa78
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2
β
Autor: Long P, Nguyen, Nour A, Al-Sawalha, Sergio, Parra, Indira, Pokkunuri, Ozozoma, Omoluabi, Adedoyin A, Okulate, Elizabeth, Windham Li, Matthew, Hazen, Jose M, Gonzalez-Granado, Craig J, Daly, John C, McGrath, Michael J, Tuvim, Brian J, Knoll, Burton F, Dickey, Richard A, Bond
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 114(43)
Activation of β2-adrenoreceptors (β2ARs) on airway smooth muscle cells produces airway relaxation, and β2AR agonists are the most widely used bronchodilators for treating asthma. Paradoxically, murine models show β2AR activation is also required
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1aab383016efb0285a6a2c878b54729f
https://pubmed.ncbi.nlm.nih.gov/29073113
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3
β 2 -Adrenoceptor signaling in airway epithelial cells promotes eosinophilic inflammation, mucous metaplasia, and airway contractility
Autor: Jose M. Gonzalez-Granado, Ozozoma Omoluabi, Michael J. Tuvim, John C. McGrath, Craig J. Daly, Indira Pokkunuri, Adedoyin A. Okulate, Richard A. Bond, Burton F. Dickey, Sergio Parra, Brian J. Knoll, Elizabeth Windham Li, Long P. Nguyen, Matthew L. Hazen, Nour A. Al-Sawalha
Publikováno v: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
The mostly widely used bronchodilators in asthma therapy are β2-adrenoreceptor (β2AR) agonists, but their chronic use causes paradoxical adverse effects. We have previously determined that β2AR activation is required for expression of the asthma p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9fd2571be12d4f93efed13cd1e50cc
https://doi.org/10.1073/pnas.1710196114
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4
Role of Adaptor Protein Toll-Like Interleukin Domain Containing Adaptor Inducing Interferon β in Toll-Like Receptor 3- and 4-Mediated Regulation of Hepatic Drug Metabolizing Enzyme and Transporter Genes
Autor: Ozozoma Omoluabi, Bhagavatula Moorthy, Pranav Shah, Romi Ghose
The expressions and activities of hepatic drug-metabolizing enzymes and transporters (DMETs) are altered during infection and inflammation. Inflammatory responses in the liver are mediated primarily by Toll-like receptor (TLR)-signaling, which involv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a158e6c7aa52c37c163d00205dc1f6
https://europepmc.org/articles/PMC4702015/
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5
Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters
Autor: Ozozoma Omoluabi, Kelley Strohacker, Adarsh Gandhi, Katie C Carpenter, Romi Ghose, Brian K. McFarlin, Tao Guo, Pranav Shah
Publikováno v: Life Sciences. 89:57-64
Our aim is to investigate the molecular mechanism of regulation of gene expression of drug metabolizing enzymes (DMEs) and transporters in diet-induced obesity.Adult male CD1 mice were fed diets containing 60% kcal fat (HFD) or 10% kcal fat (LFD) for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c269814a51a7e4f8919d2f7e683fb633
https://doi.org/10.1016/j.lfs.2011.05.005
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6
Epinephrine Activation of the β2-Adrenoceptor Is Required for IL-13-Induced Mucin Production in Human Bronchial Epithelial Cells
Autor: Brian J. Knoll, Richard A. Bond, Indira Pokkunuri, Ozozoma Omoluabi, Hosu Kim, Adrian Hernandez, Vaidehi J. Thanawala, Nour A. Al-Sawalha
Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 7, p e0132559 (2015)
Mucus hypersecretion by airway epithelium is a hallmark of inflammation in allergic asthma and results in airway narrowing and obstruction. Others have shown that administration a TH2 cytokine, IL-13 is sufficient to cause mucus hypersecretion in viv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b581057b2fbaed6e458fb42c05222b3
https://pubmed.ncbi.nlm.nih.gov/26161982
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10
Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model
Autor: Long P. Nguyen, Sergio Parra, Richard A. Bond, Ozozoma Omoluabi, Burton F. Dickey, Nicola A. Hanania, Rui Lin, Michael J. Tuvim, Brian J. Knoll
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 106(7)
Chronic regular use of β 2 -adrenoceptor (β 2 -AR) agonists in asthma is associated with a loss of disease control and increased risk of death. Conversely, we have found that administration of β 2 -AR inverse agonists results in attenuation of the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::138723735246ed081348aeca8459bf7f
https://pubmed.ncbi.nlm.nih.gov/19211783
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