Identification of genetic risk loci and causal insights associated with Parkinson's disease in African and African admixed populations: a genome-wide association study.

Autor: Rizig M; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK., Bandres-Ciga S; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Makarious MB; UCL Movement Disorders Centre, University College London, London, UK; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Ojo OO; College of Medicine, University of Lagos, Idi Araba, Lagos State, Nigeria., Crea PW; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Abiodun OV; General Hospital, Isolo, Lagos State, Nigeria., Levine KS; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Data Tecnica International, Washington, DC, USA., Abubakar SA; Ahmadu Bello University, Zaria, Kaduna State, Nigeria., Achoru CO; Jos University Teaching Hospital, Jos, Plateau State, Nigeria., Vitale D; Data Tecnica International, Washington, DC, USA., Adeniji OA; Federal Medical Centre, Abeokuta, Ogun State, Nigeria., Agabi OP; College of Medicine, University of Lagos, Idi Araba, Lagos State, Nigeria., Koretsky MJ; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Agulanna U; Lagos University Teaching Hospital, Idi Araba, Lagos State, Nigeria., Hall DA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Akinyemi RO; Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria., Xie T; Department of Neurology, University of Chicago Medicine, Chicago, IL, USA., Ali MW; Federal Teaching Hospital Gombe, Gombe State, Nigeria., Shamim EA; Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Kaiser Permanente Mid-Atlantic States, Largo, MD, USA; MidAtlantic Permanente Research Institute, Rockville, MD, USA., Ani-Osheku I; Asokoro District Hospital, Asokoro, Abuja, Nigeria., Padmanaban M; Department of Neurology, University of Chicago Medicine, Chicago, IL, USA., Arigbodi OM; Delta State University, Abraka, Delta State, Nigeria., Standaert DG; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Bello AH; University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria., Dean MN; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Erameh CO; Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria., Elsayed I; Faculty of Pharmacy, University of Gezira, Wadmadani, Sudan., Farombi TH; University College Hospital, Ibadan, Oyo State, Nigeria., Okunoye O; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK., Fawale MB; Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria., Billingsley KJ; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Imarhiagbe FA; University of Benin, Benin City, Edo State, Nigeria., Jerez PA; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Iwuozo EU; Benue State University, Makurdi, Benue State, Nigeria., Baker B; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Komolafe MA; Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria., Malik L; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Nwani PO; Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., Daida K; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Nwazor EO; Rivers State University Teaching Hospital, Port Harcourt, Rivers State, Nigeria., Miano-Burkhardt A; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Nyandaiti YW; University of Maiduguri Teaching Hospital, Maiduguri, Borno State, Nigeria., Fang ZH; German Center for Neurodegenerative Diseases, Tuebingen, Germany., Obiabo YO; Federal University of Health Sciences, Otukpo, Benue State, Nigeria., Kluss JH; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Odeniyi OA; General Hospital, Lagos Island, Lagos State, Nigeria., Hernandez DG; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Odiase FE; University of Benin, Benin City, Edo State, Nigeria., Tayebi N; Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Ojini FI; College of Medicine, University of Lagos, Idi Araba, Lagos State, Nigeria., Sidranksy E; Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Onwuegbuzie GA; University of Abuja, Abuja, Federal Capital Territory, Nigeria., D'Souza AM; Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Osaigbovo GO; Jos University Teaching Hospital, Jos, Plateau State, Nigeria., Berhe B; Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Osemwegie N; University of Port Harcourt, Port Harcourt, Rivers State, Nigeria., Reed X; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Oshinaike OO; Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria., Leonard HL; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Data Tecnica International, Washington, DC, USA., Otubogun FM; Federal Medical Center, Ebute Metta, Lagos State, Nigeria., Alvarado CX; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Data Tecnica International, Washington, DC, USA., Oyakhire SI; National Hospital, Abuja, Federal Capital Territory, Nigeria., Ozomma SI; University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria., Samuel SC; University of Maiduguri Teaching Hospital, Maiduguri, Borno State, Nigeria., Taiwo FT; University College Hospital, Ibadan, Oyo State, Nigeria., Wahab KW; University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria; University of Ilorin, Ilorin, Kwara State, Nigeria., Zubair YA; National Hospital, Abuja, Federal Capital Territory, Nigeria., Iwaki H; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Data Tecnica International, Washington, DC, USA., Kim JJ; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Morris HR; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK., Hardy J; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Nalls MA; Data Tecnica International, Washington, DC, USA., Heilbron K; 23andMe, Sunnyvale, CA, USA., Norcliffe-Kaufmann L; 23andMe, Sunnyvale, CA, USA., Blauwendraat C; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Houlden H; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK., Singleton A; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. Electronic address: singleta@nih.gov., Okubadejo NU; College of Medicine, University of Lagos, Idi Araba, Lagos State, Nigeria; Lagos University Teaching Hospital, Idi Araba, Lagos State, Nigeria. Electronic address: nokubadejo@unilag.edu.ng.

Publikováno v: The Lancet. Neurology [Lancet Neurol] 2023 Nov; Vol. 22 (11), pp. 1015-1025. Date of Electronic Publication: 2023 Aug 23.