Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Oznur Tastan"'
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-17 (2021)
Abstract Background While some non-coding RNAs (ncRNAs) are assigned critical regulatory roles, most remain functionally uncharacterized. This presents a challenge whenever an interesting set of ncRNAs needs to be analyzed in a functional context. Tr
Externí odkaz:
https://doaj.org/article/5ed31ff73b404f97aa3db98d7cfb59e2
PRER: A patient representation with pairwise relative expression of proteins on biological networks.
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 5, p e1008998 (2021)
Changes in protein and gene expression levels are often used as features in predictive modeling such as survival prediction. A common strategy to aggregate information contained in individual proteins is to integrate the expression levels with the bi
Externí odkaz:
https://doaj.org/article/a40c6d41155a43d78f645d7d833b278e
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background Long non-coding RNAs (lncRNAs) can indirectly regulate mRNAs expression levels by sequestering microRNAs (miRNAs), and act as competing endogenous RNAs (ceRNAs) or as sponges. Previous studies identified lncRNA-mediated sponge int
Externí odkaz:
https://doaj.org/article/a060b152ed7a4f8e99b1543a0356fd9b
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/ee5dae3af1e54bf38ffac3e5a8484ac1
Publikováno v:
IEEE/ACM Transactions on Computational Biology and Bioinformatics
( Early Access ) Drug combination therapies have been a viable strategy for the treatment of complex diseases such as cancer due to increased efficacy and reduced side effects. However, experimentally validating all possible combinations for synergis
Combination drug therapies are effective treatments for cancer. However, the genetic heterogeneity of the patients and exponentially large space of drug pairings pose significant challenges for finding the right combination for a specific patient. Cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f80eae1af85146f2098720eb4e04bc52
https://doi.org/10.1101/2023.02.13.528276
https://doi.org/10.1101/2023.02.13.528276
Publikováno v:
Bioinformatics
MotivationGenome-wide association studies show that variants in individual genomic loci alone are not sufficient to explain the heritability of complex, quantitative phenotypes. Many computational methods have been developed to address this issue by
Publikováno v:
Molecular Biology and Evolution. 39
Evolutionary conservation is a fundamental resource for predicting the substitutability of amino acids and the loss of function in proteins. The use of multiple sequence alignment alone—without considering the evolutionary relationships among seque
Publikováno v:
Journal of Computational Biology. 28:365-377
Genome-wide association studies explain a fraction of the underlying heritability of genetic diseases. Investigating epistatic interactions between two or more loci help closing this gap. Unfortunately, sheer number of loci combinations to process an
Publikováno v:
Bioinformatics (Oxford, England). 39(1)
Motivation Recent experimental evidence has shown that some long non-coding RNAs (lncRNAs) contain small open reading frames (sORFs) that are translated into functional micropeptides, suggesting that these lncRNAs are misannotated as non-coding. Curr