Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion

Autor: Ozlem Senol-Cosar, Rachel J. Roth Flach, Marina DiStefano, Anil Chawla, Sarah Nicoloro, Juerg Straubhaar, Olga T. Hardy, Hye Lim Noh, Jason K. Kim, Martin Wabitsch, Philipp E. Scherer, Michael P. Czech

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

Expansion of visceral adipose tissue is usually associated with insulin resistance and metabolic disease. Here, the authors show that the membrane protein TNMD is upregulated in visceral fat of insulin resistant obese individuals and promotes healthy

Externí odkaz: https://doaj.org/article/2b8301dcb67b41eabe00ec0fa2a01c48

Supplementary Figures 1-5 from miRNA-7 Attenuation in Schwannoma Tumors Stimulates Growth by Upregulating Three Oncogenic Signaling Pathways

Autor: Xandra O. Breakefield, Gary J. Brenner, Nurten Saydam, Anna M. Krichevsky, Robert M. Stephens, Ming Yi, Anat O. Stemmer-Rachamimov, Gokhan Baris Ozdener, Arda Mizrak, Thomas Würdinger, Ozlem Senol, Okay Saydam

Supplementary Figures 1-5 from miRNA-7 Attenuation in Schwannoma Tumors Stimulates Growth by Upregulating Three Oncogenic Signaling Pathways

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c69fae4fc5551ffad5b0dbb8b6116a
https://doi.org/10.1158/0008-5472.22388864.v1

A survey assessing adoption of the ACMG-AMP guidelines for interpreting sequence variants and identification of areas for continued improvement

Autor: Marina T. DiStefano, Annie Niehaus, Sarah E. Hemphill, Heidi L. Rehm, Ozlem Senol-Cosar, Danielle R. Azzariti, Steven M. Harrison

Publikováno v: Genetics in medicine : official journal of the American College of Medical Genetics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2cb2836e3ccd13b32e9e9df5f70c21c
http://europepmc.org/articles/PMC7233466

Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance

Autor: Olga T. Gupta, Joseph V. Virbasius, Rachel J. Roth Flach, Ozlem Senol-Cosar, Sezin Dagdeviren, Laura V. Danai, Juerg R. Straubhaar, Marina T. DiStefano, Sarah M. Nicoloro, Jason K. Kim, Michael P. Czech, Martin Wabitsch

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 5, Iss 12, Pp 1149-1161 (2016)

Objective Adipose tissue relies on lipid droplet (LD) proteins in its role as a lipid-storing endocrine organ that controls whole body metabolism. Hypoxia-inducible Gene 2 (Hig2) is a recently identified LD-associated protein in hepatocytes that prom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276376435f44936349d032e77ee12973

Polygenic prediction of weight and obesity trajectories from birth to adulthood

Autor: Mark Chaffin, Krishna G. Aragam, Nicholas J. Timpson, Ozlem Senol-Cosar, Alexander G. Bick, Matthew S. Lebo, Mary E. Haas, Sohail Zahid, Lee M. Kaplan, Heather Mason-Suares, Sekar Kathiresan, Marina T. DiStefano, Amit Khera, Kaitlin H Wade, Rui Xia, George Davey Smith, Myriam Fornage, Eric S. Lander, Joseph Brancale

Publikováno v: Khera, A V, Chaffin, M, Wade, K H, Zahid, S, Brancale, J, Xia, R, Distefano, M, Senol-Cosar, O, Haas, M E, Bick, A, Aragam, K G, Lander, E S, Smith, G D, Mason-Suares, H, Fornage, M, Lebo, M, Timpson, N J, Kaplan, L M & Kathiresan, S 2019, ' Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood ', Cell, vol. 177, no. 3, pp. 587-596.e9 . https://doi.org/10.1016/j.cell.2019.03.028
PMC

Severe obesity is a rapidly growing global health threat. Although often attributed to unhealthy lifestyle choices or environmental factors, obesity is known to be heritable and highly polygenic; the majority of inherited susceptibility is related to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818a8eba2d6b4ea4b9dc356086cec7d8
https://europepmc.org/articles/PMC6661115/