Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Ozlem Altay"'
Autor:
Lingqi Meng, Han Jin, Burak Yulug, Ozlem Altay, Xiangyu Li, Lutfu Hanoglu, Seyda Cankaya, Ebru Coskun, Ezgi Idil, Rahim Nogaylar, Ahmet Ozsimsek, Saeed Shoaie, Hasan Turkez, Jens Nielsen, Cheng Zhang, Jan Borén, Mathias Uhlén, Adil Mardinoglu
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder with a global impact, yet its pathogenesis remains poorly understood. While age, metabolic abnormalities, and accumulation of neurotoxic substances are potential risk fa
Externí odkaz:
https://doaj.org/article/39a09c10d79c4cb7af897566df85c1bc
Autor:
Atakan Burak Ceyhan, Mehmet Ozcan, Woonghee Kim, Xiangyu Li, Ozlem Altay, Cheng Zhang, Adil Mardinoglu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116920- (2024)
Sarcopenia is a major public health concern among older adults, leading to disabilities, falls, fractures, and mortality. This study aimed to elucidate the pathophysiological mechanisms of sarcopenia and identify potential therapeutic targets using s
Externí odkaz:
https://doaj.org/article/b853d1d5a56641ae98a857fd8d4fbd9f
Autor:
Ozlem Altay, Hong Yang, Serkan Yildirim, Cemil Bayram, Ismail Bolat, Sena Oner, Ozlem Ozdemir Tozlu, Mehmet Enes Arslan, Ahmet Hacimuftuoglu, Saeed Shoaie, Cheng Zhang, Jan Borén, Mathias Uhlén, Hasan Turkez, Adil Mardinoglu
Publikováno v:
Biomedicines, Vol 12, Iss 4, p 927 (2024)
Background: Mitochondrial dysfunction and metabolic abnormalities are acknowledged as significant factors in the onset of neurodegenerative disorders such as Parkinson’s disease (PD) and Alzheimer’s disease (AD). Our research has demonstrated tha
Externí odkaz:
https://doaj.org/article/82d23cf6ae5d4d6bb1de51ae8dca2f4e
Autor:
Ishak Suat Ovey, Ahmet Ozsimsek, Halil Aziz Velioglu, Ozlem Altay, Adil Mardinoglu, Burak Yulug
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
BackgroundTransient receptor potential (TRP) channels have been found to have significant implications in neuronal outgrowth, survival, inflammatory neurogenic pain, and various epileptogenic processes. Moreover, there is a growing body of evidence i
Externí odkaz:
https://doaj.org/article/72b0694c9619448a9577e32081f88c51
Autor:
Burak Yulug, Ozlem Altay, Xiangyu Li, Lutfu Hanoglu, Seyda Cankaya, Simon Lam, Halil Aziz Velioglu, Hong Yang, Ebru Coskun, Ezgi Idil, Rahim Nogaylar, Ahmet Ozsimsek, Cemil Bayram, Ismail Bolat, Sena Oner, Ozlem Ozdemir Tozlu, Mehmet Enes Arslan, Ahmet Hacimuftuoglu, Serkan Yildirim, Muhammad Arif, Saeed Shoaie, Cheng Zhang, Jens Nielsen, Hasan Turkez, Jan Borén, Mathias Uhlén, Adil Mardinoglu
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-23 (2023)
Abstract Background Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administered combined metabolic activators (CMA) to the AD rat model and observed that CMA improve
Externí odkaz:
https://doaj.org/article/278f5ef5f370458b8e4a1065e71e2ca4
Autor:
Mujdat Zeybel, Ozlem Altay, Muhammad Arif, Xiangyu Li, Hong Yang, Claudia Fredolini, Murat Akyildiz, Burcin Saglam, Mehmet Gokhan Gonenli, Dilek Ural, Woonghee Kim, Jochen M Schwenk, Cheng Zhang, Saeed Shoaie, Jens Nielsen, Mathias Uhlén, Jan Borén, Adil Mardinoglu
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 10, Pp 1-18 (2021)
Abstract Nonalcoholic fatty liver disease (NAFLD) refers to excess fat accumulation in the liver. In animal experiments and human kinetic study, we found that administration of combined metabolic activators (CMAs) promotes the oxidation of fat, atten
Externí odkaz:
https://doaj.org/article/458a964c837f412a952dd9635ecd9b5f
Autor:
Mujdat Zeybel, Muhammad Arif, Xiangyu Li, Ozlem Altay, Hong Yang, Mengnan Shi, Murat Akyildiz, Burcin Saglam, Mehmet Gokhan Gonenli, Buket Yigit, Burge Ulukan, Dilek Ural, Saeed Shoaie, Hasan Turkez, Jens Nielsen, Cheng Zhang, Mathias Uhlén, Jan Borén, Adil Mardinoglu
Publikováno v:
Advanced Science, Vol 9, Iss 11, Pp n/a-n/a (2022)
Abstract Metabolic dysfunction‐associated fatty liver disease (MAFLD) is a complex disease involving alterations in multiple biological processes regulated by the interactions between obesity, genetic background, and environmental factors including
Externí odkaz:
https://doaj.org/article/f0323763de524d1baed15e3811c0095e
Autor:
Wen Zhong, Ozlem Altay, Muhammad Arif, Fredrik Edfors, Levent Doganay, Adil Mardinoglu, Mathias Uhlen, Linn Fagerberg
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103723- (2021)
Background: COVID-19 has caused millions of deaths globally, yet the cellular mechanisms underlying the various effects of the disease remain poorly understood. Recently, a new analytical platform for comprehensive analysis of plasma protein profiles
Externí odkaz:
https://doaj.org/article/7164b72146b44fdc9e77d6fdcc3f62b6
Autor:
Ozlem Altay, Muhammad Arif, Xiangyu Li, Hong Yang, Mehtap Aydın, Gizem Alkurt, Woonghee Kim, Dogukan Akyol, Cheng Zhang, Gizem Dinler‐Doganay, Hasan Turkez, Saeed Shoaie, Jens Nielsen, Jan Borén, Oktay Olmuscelik, Levent Doganay, Mathias Uhlén, Adil Mardinoglu
Publikováno v:
Advanced Science, Vol 8, Iss 17, Pp n/a-n/a (2021)
Abstract COVID‐19 is associated with mitochondrial dysfunction and metabolic abnormalities, including the deficiencies in nicotinamide adenine dinucleotide (NAD+) and glutathione metabolism. Here it is investigated if administration of a mixture of
Externí odkaz:
https://doaj.org/article/b932227903334fd089c994a3da7f40a6
Publikováno v:
EBioMedicine, Vol 49, Iss , Pp 364-373 (2019)
The advancement in high-throughput sequencing technologies and systems biology approaches have revolutionized our understanding of biological systems and opened a new path to investigate unacknowledged biological phenomena. In parallel, the field of
Externí odkaz:
https://doaj.org/article/617acadb0bc14ea894b3420f8af1adc6