Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ozhan Ocal"'
Autor:
Ozhan Ocal, Victor Pashkov, Rahul K. Kollipara, Yalda Zolghadri, Victoria H. Cruz, Michael A. Hale, Blake R. Heath, Alex B. Artyukhin, Alana L. Christie, Pantelis Tsoulfas, James B. Lorens, Galvin H. Swift, Rolf A. Brekken, Thomas M. Wilkie
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 10, Pp 1201-1211 (2015)
Pancreatic ductal adenocarcinoma (PDA) is the fourth leading cause of cancer-related deaths in the United States, and is projected to be second by 2025. It has the worst survival rate among all major cancers. Two pressing needs for extending life exp
Externí odkaz:
https://doaj.org/article/e60bcc9609124742ac32110e16dccedf
Autor:
Havish S. Kantheti, Ana Clara Azevedo-Pouly, Somayeh Layeghi-Ghalehsoukhteh, Bruce A. Posner, Huocong Huang, Shreoshi Pal Choudhuri, Raymond J. MacDonald, Hanspeter Niederstrasser, Victor Pashkov, Luc Girard, Rolf A. Brekken, Thomas M. Wilkie, Ozhan Ocal, Yalda Zolghadri
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
PDA is a major cause of US cancer-related deaths. Oncogenic Kras presents in 90% of human PDAs. Kras mutations occur early in pre-neoplastic lesions but are insufficient to cause PDA. Other contributing factors early in disease progression include ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2bfa0234d5376ebe2f49004f8cf2c68
http://link.springer.com/article/10.1038/s41598-020-77373-8
http://link.springer.com/article/10.1038/s41598-020-77373-8
Autor:
Yalda Zolghadri, Thomas M. Wilkie, Shreoshi Pal Choudhuri, Somayeh Layeghi-Ghalehsoukhteh, Ozhan Ocal, Michael A. Hale, Feaven Berhe
Publikováno v:
The American Journal of Pathology. 188:616-626
Pancreatic ductal adenocarcinoma (PDA) is a deadly cancer that resists efforts to identify better chemotherapeutics. PDA is associated with chronic pancreatitis and acinar cell dedifferentiation. This reduces enzyme production by the exocrine pancrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b9befe9a76db60540b205c9152cbef4
https://doi.org/10.1016/j.ajpath.2017.11.014
https://doi.org/10.1016/j.ajpath.2017.11.014
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2de6502a76a455ca5c222b75f10ed51
https://doi.org/10.1096/fasebj.2019.33.1_supplement.647.29
https://doi.org/10.1096/fasebj.2019.33.1_supplement.647.29
Publikováno v:
Cancer Research. 79:1790-1790
Pancreatic Ductal Adenocarcinoma (PDA) is the most common form of pancreatic cancer driven primarily by mutations in V-Ki-Ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (Kras) gene. Its most common mutation, G12D, cause KRAS to remain constitutively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ee1e4b69396d8759dfa4b14ab99962d
https://doi.org/10.1158/1538-7445.am2019-1790
https://doi.org/10.1158/1538-7445.am2019-1790
Autor:
Yanneve Rolland, Claude Godbout, Hui Ding, Alexandre Bramoullé, Michel O. Steinmetz, Rolf A. Brekken, Patrick G. Harran, Sami Chaaban, Thomas M. Wilkie, Ozhan Ocal, Natacha Olieric, Peter M. Siegel, Anne Roulston, Joseph C. Arezzo, Matthew G. Annis, Gary J. Brouhard, Cynthia Bernier, Mark A. Hancock, Cecilia Rocha, Anita Hall, Andrea E. Prota, Joseph Tcherkezian, Michal Wieczorek, George Zogopoulos, Gordon C. Shore
Publikováno v:
Science translational medicine, vol 8, iss 365
Microtubule-targeting agents (MTAs) are widely used anticancer agents, but toxicities such as neuropathy limit their clinical use. MTAs bind to and alter the stability of microtubules, causing cell death in mitosis. We describe DZ-2384, a preclinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38a6fb17c4299685199025dd72f9ddc
https://escholarship.org/uc/item/9dr6h535
https://escholarship.org/uc/item/9dr6h535
Autor:
Philipp E. Scherer, Ozhan Ocal, Alethia Villasenor, Zhao V. Wang, Rolf A. Brekken, Lee B. Rivera, Ondine Cleaver, Thomas M. Wilkie, Ingrid Wernstedt Asterholm
Publikováno v:
Disease Models & Mechanisms. 3:567-580
SUMMARYDiabetes is characterized by the loss, or gradual dysfunction, of insulin-producing pancreatic β-cells. Although β-cells can replicate in younger adults, the available diabetes therapies do not specifically target β-cell regeneration. Novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b7d6efc276211b3e6ced75a648ecc7
https://doi.org/10.1242/dmm.003210
https://doi.org/10.1242/dmm.003210
Autor:
Victor Pashkov, Yalda Zolghadri, Galvin H. Swift, Ozhan Ocal, Michael A. Hale, Victoria H. Cruz, Rahul K. Kollipara, Rolf A. Brekken, Alana Christie, Alexander B. Artyukhin, James B. Lorens, Thomas M. Wilkie, Blake Heath, Pantelis Tsoulfas
Publikováno v:
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 8, Iss 10, Pp 1201-1211 (2015)
Disease Models & Mechanisms, Vol 8, Iss 10, Pp 1201-1211 (2015)
Pancreatic ductal adenocarcinoma (PDA) is the fourth leading cause of cancer-related deaths in the United States, and is projected to be second by 2025. It has the worst survival rate among all major cancers. Two pressing needs for extending life exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de3cb45a6ca0a8b09b40cdeacf282f6
https://pubmed.ncbi.nlm.nih.gov/26438693
https://pubmed.ncbi.nlm.nih.gov/26438693
Publikováno v:
The FASEB Journal. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93ae269ce7d8e0f2f5f2707fec461940
https://doi.org/10.1096/fasebj.29.1_supplement.618.10
https://doi.org/10.1096/fasebj.29.1_supplement.618.10
Publikováno v:
Cancer Research. 77:5518-5518
We have identified regulators of G protein signaling (Rgs8 and Rgs16) as a new class of tumor suppressor genes in a mouse model of pancreatic ductal adenocarcinoma (PDA). PDA is the 3rd leading cause of cancer related deaths in the United States. Kra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dd6def24b58ece98ec614e566638115
https://doi.org/10.1158/1538-7445.am2017-5518
https://doi.org/10.1158/1538-7445.am2017-5518