Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ozgecan Savlug Ipek"'
Autor:
Damla Uludağ, Sadık Bay, Bilgesu Onur Sucu, Özgecan Şavluğ İpek, Thomas Mohr, Mustafa Güzel, Nihal Karakaş
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Change in the energy metabolism of cancer cells, which display significant differences compared to normal cells, is a rising phenomenon in developing new therapeutic approaches against cancers. One of the metabolic enzymes, hexokinase-II (HK-II) is i
Externí odkaz:
https://doaj.org/article/2f2e98f9bf9a49a594df53503809c75d
Autor:
Seref Gul, Yasemin Kubra Akyel, Zeynep Melis Gul, Safak Isin, Onur Ozcan, Tuba Korkmaz, Saba Selvi, Ibrahim Danis, Ozgecan Savlug Ipek, Fatih Aygenli, Ali Cihan Taskin, Büşra Aytül Akarlar, Nurhan Ozlu, Nuri Ozturk, Narin Ozturk, Durişehvar Özer Ünal, Mustafa Guzel, Metin Turkay, Alper Okyar, Ibrahim Halil Kavakli
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Cryptochromes are transcriptional regulators of the circadian clock in mammals, and genetic loss of cryptochromes reduces p53-associated cancer risk in mice. Here the authors report the discovery of small molecule M47, which destabilizes cryptochrome
Externí odkaz:
https://doaj.org/article/74ebf0d9b13b4f24b201b187236a7cc6
Publikováno v:
Journal of Molecular Structure. 1281:135114
In order to develop drugs against cancer, which is one of the deadliest diseases in the world, hybridizing structures with known anticancer activity can provide a dual activity for the treatment of cancer cases. For this purpose, a series of novel hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13f85c647bf98b6f928f5ee617fbf6d
https://doi.org/10.1016/j.molstruc.2023.135114
https://doi.org/10.1016/j.molstruc.2023.135114
Autor:
Bilgesu Onur Sucu, Elif Beyza Koc, Ozgecan Savlug Ipek, Afranur Mirat, Furkan Almas, Melike Aybala Guzel, Berna Dogan, Damla Uludag, Nihal Karakas, Serdar Durdagi, Mustafa Guzel
Glioblastoma Multiforme (GBM) is the most aggressive brain tumor and classified as one of the deadliest cancers. The current treatment plans for GBM remains to be ineffective because of its rapid progress and inability of the drugs used to cross the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f4e8f713887971e8f5a0a382e20fdc
https://hdl.handle.net/20.500.12511/9120
https://hdl.handle.net/20.500.12511/9120
Autor:
Saba Selvi, Yasemin Kubra Akyel, Mustafa Guzel, Fatih Aygenli, Nuri Ozturk, Ali Cihan Taskin, Safak Isin, Durisehvar Ozer Unal, Ibrahim Danis, Metin Turkay, Ozgecan Savlug Ipek, Seref Gul, Zeynep Melis Gul, Narin Ozturk, Alper Okyar, Tuba Korkmaz, Ibrahim Halil Kavakli
Cryptochromes are negative transcriptional regulators of the circadian clock in mammals. It is not clear how reducing the level of endogenous level of the CRY1 in mammals will affect circadian rhythm and the relation of such a decrease with apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03a2d1288d0a764da3ba1cf2f8bf2a8d
https://doi.org/10.1101/2021.07.21.453206
https://doi.org/10.1101/2021.07.21.453206
Autor:
Seref Gul, Yasemin Kubra Akyel, Zeynep Melis Gul, Safak Isin, Onur Ozcan, Tuba Korkmaz, Saba Selvi, Ibrahim Danis, Ozgecan Savlug Ipek, Fatih Aygenli, Ali Cihan Taskin, Büşra Aytül Akarlar, Nurhan Ozlu, Nuri Ozturk, Narin Ozturk, Durişehvar Özer Ünal, Mustafa Guzel, Metin Turkay, Alper Okyar, Ibrahim Halil Kavakli
Publikováno v:
Nature Communications
Cryptochromes are negative transcriptional regulators of the circadian clock in mammals. It is not clear how reducing the level of endogenous CRY1 in mammals will affect circadian rhythm and the relation of such a decrease with apoptosis. Here, we di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a15ca742cbd52392b0eafb83cb5d0e
https://pubmed.ncbi.nlm.nih.gov/36347873
https://pubmed.ncbi.nlm.nih.gov/36347873
Publikováno v:
Chemical Engineering Journal. 434:133868
Conductive polymers are considered to be promising material for energy storage applications. Herein, a microporous hybrid energy storage material made of triphenylamine and dithienothiophene, having smart function charge property controlled by color
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5f27d4cb3115c8a062f230e80be14a0
https://doi.org/10.1016/j.cej.2021.133868
https://doi.org/10.1016/j.cej.2021.133868
Autor:
Bilgesu Onur Sucu, Sukran Ozdatli Kurtulus, Busra Emine Yazici, Nihal Karakaş, Ozgecan Savlug Ipek, Mustafa Guzel
Warburg hypothesized that the energy consumption of cancer cells is different than the normal cells. When compared to normal conditions, cancer cells do not undergo tricarboxylic acid (TCA) cycle therefore resulting in more lactate in the cells. Glyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08103ef2f855afddb38cd041912d5087
https://hdl.handle.net/20.500.12511/4682
https://hdl.handle.net/20.500.12511/4682
Autor:
Hatice Başpınar Küçük, Mustafa Guzel, Ozgecan Savlug Ipek, Ayşe Esra Karadağ, Betül Giray, Hanife Pekel
Publikováno v:
Bioorganic Chemistry. 95:103509
In drug-resistant phytopathogenic fungi, there has been extensive research on microbiological and antifungal drug development. In this study, a novel series of cylopentapyrazole bearing a 1,2,3-thiadiazole ring 2a-e were designed and synthesized acco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2573ad81983de6603c49d8b6daa8b645
https://doi.org/10.1016/j.bioorg.2019.103509
https://doi.org/10.1016/j.bioorg.2019.103509