Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Ozden Tacal"'
Publikováno v:
Molecules, Vol 25, Iss 3, p 533 (2020)
A newly recognized action of organophosphates (OP) is the ability to crosslink proteins through an isopeptide bond. The first step in the mechanism is covalent addition of the OP to the side chain of lysine. This activates OP-lysine for reaction with
Externí odkaz:
https://doaj.org/article/21c08762431a40babeb7a94c70a163a4
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Human butyrylcholinesterase (BChE) is purified in large quantities from Cohn fraction IV-4 to use for protection against the toxicity of chemical warfare agents. Small scale preliminary experiments use outdated plasma from the American Red Cross as t
Externí odkaz:
https://doaj.org/article/5ef6f000670b45a3b0fcefcf272f8f11
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Hupresin is a new affinity resin that binds butyrylcholinesterase (BChE) in human plasma and acetylcholinesterase (AChE) solubilized from red blood cells (RBC). Hupresin is available from the CHEMFORASE company. BChE in human plasma binds to Hupresin
Externí odkaz:
https://doaj.org/article/306a5261570548f0ae06ec4dc404d69d
Publikováno v:
Neurotoxicology
Cultured SH-SY5Y human neuroblastoma cells are used in neurotoxicity assays. These cells express markers of the cholinergic and dopaminergic systems. Acetylcholinesterase (AChE) activity has been reported in these cells. Neurotoxic organophosphate co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c6914486963965bc4cf4fac2371c2d
https://doi.org/10.1016/j.neuro.2022.02.006
https://doi.org/10.1016/j.neuro.2022.02.006
Publikováno v:
Drug Development Research. 83:900-909
Amyloid precursor-like protein-2 (APLP2) and its C-terminal fragments (CTFs) are expressed at high levels in pancreatic cancer cells and knockdown of APLP2 expression inhibits tumor growth. CTFs are released from APLP2 by beta-secretase (BACE). In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6320a3634c74f0b665f5a36bcf7026
https://doi.org/10.1002/ddr.21915
https://doi.org/10.1002/ddr.21915
Autor:
Gaoping Xiao, Seda Onder, Daan Noort, Oksana Lockridge, Lawrence M. Schopfer, A. Fidder, Udaya Yerramalla, Ozden Tacal, Marco van Grol
Publikováno v:
Journal of Proteome Research
Chronic low-dose exposure to organophosphorus pesticides is associated with the risk of neurodegenerative disease. The mechanism of neurotoxicity is independent of acetylcholinesterase inhibition. Adducts on tyrosine, lysine, threonine, and serine ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9082411d7a68d6e70c2d1050b434502
https://doi.org/10.1021/acs.jproteome.1c00383
https://doi.org/10.1021/acs.jproteome.1c00383
Publikováno v:
Chemico-biological interactions. 366
Alzheimer's disease (AD) is characterized by extracellular amyloid plaques composed of amyloid-β peptide (Aβ), intracellular neurofibrillary tangles containing hyperphosphorylated tau protein and neuronal loss. Most of the FDA-approved AD drugs cur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0004839b1b627a021f0965162bcdf5ec
https://pubmed.ncbi.nlm.nih.gov/36027949
https://pubmed.ncbi.nlm.nih.gov/36027949
Publikováno v:
Chemico-biological interactions. 363
Epidemiological evidence suggests that people chronically exposed to organophosphorus pesticides are at increased risk of neurodegenerative disease. Covalently linked amyloid beta dimers have been isolated from the brains of Alzheimer's patients. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e286484a29865b13aac21a58950161
https://pubmed.ncbi.nlm.nih.gov/35779611
https://pubmed.ncbi.nlm.nih.gov/35779611
Publikováno v:
Anal Biochem
Glutamine residues susceptible to transglutaminase-catalyzed crosslinking can be identified by incorporation of dansyl cadaverine or biotin cadaverine. Bacterial transglutaminase and human transglutaminase 2 were used to modify residues in beta-casei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f791252b91b2e53b4949d8f1f0b2318
https://europepmc.org/articles/PMC7302536/
https://europepmc.org/articles/PMC7302536/
Autor:
Thomas A. Blake, Rudolph C. Johnson, Lawrence M. Schopfer, Oksana Lockridge, Seda Onder, Ozden Tacal
Publikováno v:
Chemical Research in Toxicology. 31:520-530
Chronic illness from exposure to organophosphorus toxicants is hypothesized to involve modification of unknown proteins. Tyrosine in proteins that have no active site serine readily reacts with organophosphorus toxicants. We developed a monoclonal an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d7b8ae56b42ed72e8b05511e11950f
https://doi.org/10.1021/acs.chemrestox.8b00083
https://doi.org/10.1021/acs.chemrestox.8b00083