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Development of high-throughput screening assays for profiling snake venom phospholipase A2 activity after chromatographic fractionation

Autor: Govert W. Somsen, Sarah Kidwai, Julien Slagboom, Zhengjin Jiang, Bastiaan Eisses, Chunfang Xie, Kristina B.M. Still, Jeroen Kool, Nicholas R. Casewell, Yumei Zhao, Freek J. Vonk

Publikováno v: Still, K B M, Slagboom, J, Kidwai, S, Xie, C, Zhao, Y, Eisses, B, Jiang, Z, Vonk, F J, Somsen, G W, Casewell, N R & Kool, J 2020, ' Development of high-throughput screening assays for profiling snake venom phospholipase A 2 activity after chromatographic fractionation ', Toxicon, vol. 184, pp. 28-38 . https://doi.org/10.1016/j.toxicon.2020.05.022
Toxicon, 184, 28-38. Elsevier Limited

Many organisms, ranging from plants to mammals, contain phospholipase A2 enzymes (PLA2s), which catalyze the production of lysophospholipids and fatty acid proinflammatory mediators. PLA2s are also common constituents of animal venoms, including bees

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2cfc6e54b87cc0590c27333c4578e53
https://research.vu.nl/en/publications/ff8e2e0f-7f4e-46f9-84d0-925208592cdc

In-Vitro Neutralization of the Neurotoxicity of Coastal Taipan Venom by Australian Polyvalent Antivenom: The Window of Opportunity

Autor: Wayne C. Hodgson, Anjana Silva, Geoffrey K. Isbister, Theo Tasoulis, Umesha Madhushani

Publikováno v: Toxins
Volume 12
Issue 11
Toxins, Vol 12, Iss 690, p 690 (2020)

Coastal taipan (Oxyuranus scutellatus) envenoming causes life-threatening neuromuscular paralysis in humans. We studied the time period during which antivenom remains effective in preventing and arresting in vitro neuromuscular block caused by taipan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a2b441346e126389bc415dba401ede
https://pubmed.ncbi.nlm.nih.gov/33142783

Varespladib Inhibits the Phospholipase A2 and Coagulopathic Activities of Venom Components from Hemotoxic Snakes

Autor: Julien Slagboom, Nicholas R. Casewell, Govert W. Somsen, Zhengjin Jiang, Freek J. Vonk, Yumei Zhao, Jeroen Kool, Laura-Oana Albulescu, Kristina B.M. Still, Chunfang Xie

Publikováno v: Biomedicines
Volume 8
Issue 6
Biomedicines, Vol 8, Iss 165, p 165 (2020)
Xie, C, Albulescu, L O, Still, K B M, Slagboom, J, Zhao, Y, Jiang, Z, Somsen, G W, Vonk, F J, Casewell, N R & Kool, J 2020, ' Varespladib inhibits the phospholipase A 2 and coagulopathic activities of venom components from hemotoxic snakes ', Biomedicines, vol. 8, no. 6, 165, pp. 1-17 . https://doi.org/10.3390/biomedicines8060165
Biomedicines, 8(6):165, 1-17. MDPI AG

Phospholipase A2 (PLA2) enzymes are important toxins found in many snake venoms, and they can exhibit a variety of toxic activities including causing hemolysis and/or anticoagulation. In this study, the inhibiting effects of the small molecule PLA2 i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f876f0f58598a5e95659ee4aa142fa52

An agonist of the CXCR4 receptor accelerates the recovery from the peripheral neuroparalysis induced by Taipan snake envenomation

Autor: Florigio Lista, Cesare Montecucco, Giorgia D’Este, Samuele Negro, Michela Rigoni, Marco Stazi, Andrea Mattarei, Aram Megighian

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 14, Iss 9, p e0008547 (2020)

Envenomation by snakes is a major neglected human disease. Hospitalization and use of animal-derived antivenom are the primary therapeutic supports currently available. There is consensus that additional, not expensive, treatments that can be deliver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52841ff692c12c7423800a675a4f08fd
https://pubmed.ncbi.nlm.nih.gov/32898186