GBA3: a polymorphic pseudogene in humans that experienced repeated gene loss during mammalian evolution

Autor: Renato Salazar, Maria João Prata, Susana Seixas, Ana Rita Cardoso, Mónica Lopes-Marques, Luísa Azevedo, Catarina Serrano, António Amorim

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)

The gene encoding the cytosolic ß-glucosidase GBA3 shows pseudogenization due to a truncated allele (rs358231) that is polymorphic in humans. Since this enzyme is involved in the transformation of many plant ß-glycosides, this particular case of ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac60c47e0684912a66798b58d138f3c
https://doi.org/10.1038/s41598-020-68106-y

A comparison of the embryonic stem cell test and whole embryo culture assay combined with the BeWo placental passage model for predicting the embryotoxicity of azoles

Autor: Dimopoulou, Myrto, Verhoef, Aart, Gomes, Caroline A, van Dongen, Catharina W, Rietjens, Ivonne M C M, Piersma, Aldert H, van Ravenzwaay, Bennard, Sub RIVM, dIRAS RA-1

Publikováno v: Toxicology Letters, 286, 10-21
Toxicology Letters, 286, 10. Elsevier Ireland Ltd.
Toxicology Letters 286 (2018)

In the present study, we show the value of combining toxico-dynamic and -kinetic in vitro approaches for embryotoxicity testing of azoles. Both the whole embryo culture (WEC) and the embryonic stem cells test (EST) predicted the in vivo potency ranki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7c0cd68481a06c942188279cd9a67d
https://research.wur.nl/en/publications/a-comparison-of-the-embryonic-stem-cell-test-and-whole-embryo-cul

Crenothrix are major methane consumers in stratified lakes

Autor: Jon S. Graf, Bernhard Wehrli, Michael Wagner, Jana Milucka, Carsten J. Schubert, Marcel M. M. Kuypers, Holger Daims, Mads Albertsen, Andreas Brand, Daniela Tienken, Sten Littmann, Kirsten Oswald

Publikováno v: The ISME Journal, 11 (9)
The ISME Journal
Oswald, K, Graf, J S, Littmann, S, Tienken, D, Brand, A, Wehrli, B, Albertsen, M, Daims, H, Wagner, M, Kuypers, M M, Schubert, C J & Milucka, J 2017, ' Crenothrix are major methane consumers in stratified lakes ', I S M E Journal, vol. 11, no. 9, pp. 2124-2140 . https://doi.org/10.1038/ismej.2017.77

Methane-oxidizing bacteria represent a major biological sink for methane and are thus Earth’s natural protection against this potent greenhouse gas. Here we show that in two stratified freshwater lakes a substantial part of upward-diffusing methane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467a3a725d0712f158e767fdd7e29461
https://hdl.handle.net/20.500.11850/191321

Warfarin pharmacogenetics: development of a dosing algorithm for Omani patients

Autor: Rajagopal Krishnamoorthy, Shoaib Al Zadjali, Andras Paldi, Claudine Lapoumeroulie, Rhea Misquith, Murtadha Al Khabori, Hammad Khan, Salam Alkindi, Anil Pathare

Publikováno v: J Hum Genet
J Hum Genet, 2012, 57 (10), pp.665-9. ⟨10.1038/jhg.2012.94⟩

International audience; The objective of our present study was to develop a warfarin dosing algorithm for the Omani patients, as performances of warfarin dosing algorithms vary across populations with impact on the daily maintenance dose. We studied

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f827ce1cae3828ebb434fc84d43047
https://hal.archives-ouvertes.fr/hal-02881146

Biological effect of increased maintenance dose of clopidogrel in cardiovascular outpatients and influence of the cytochrome P450 2C19*2 allele on clopidogrel responsiveness

Autor: François Mach, Pierre Fontana, David Senouf

Publikováno v: Thrombosis Research, Vol. 121, No 4 (2008) pp. 463-8

INTRODUCTION: The first aim of this study is to evaluate the biological effect of doubling the maintenance dose of clopidogrel in pre-defined clopidogrel "low responders", compared to the biological effect of the standard dose in "responders". The se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbaca3dfa9dc0f7aba3d6b3d75614f3a
https://archive-ouverte.unige.ch/unige:832