Výsledky vyhledávání - "Oxygen dependent degradation"

Hypoxia Patterns in Primary and Metastatic Prostate Cancer Environments1

Autor: Bharti, Santosh Kumar, Kakkad, Samata, Danhier, Pierre, Wildes, Flonne, Penet, Marie-France, Krishnamachary, Balaji, Bhujwalla, Zaver M.

Publikováno v: Neoplasia (New York, N.Y.)

Metastatic dissemination continues to be a major cause of prostate cancer (PCa) mortality, creating a compelling need to understand factors that play a role in the metastatic cascade. Since hypoxia plays an important role in PCa aggressiveness, we ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c6f38356a6e9ab880a6ca22b1093aec1
http://europepmc.org/articles/PMC6327878

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Hypoxia enhances H2O2-mediated upregulation of hepcidin: Evidence for NOX4-mediated iron regulation

Autor: Inês Silva, Vanessa Rausch, Teresa Peccerella, Gunda Millonig, Helmut-Karl Seitz, Sebastian Mueller

Publikováno v: Redox Biology
Redox Biology, Vol 16, Iss, Pp 1-10 (2018)

The exact regulation of the liver-secreted peptide hepcidin, the key regulator of systemic iron homeostasis, is still poorly understood. It is potently induced by iron, inflammation, cytokines or H2O2 but conflicting results have been reported on hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::465fdbd6640587cef924018030a10826
http://europepmc.org/articles/PMC5832675

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High-altitude deer mouse hypoxia-inducible factor-2α shows defective interaction with CREB-binding protein

Autor: Frank S. Lee, Abigail W. Bigham, Daisheng Song

Publikováno v: The Journal of Biological Chemistry

Numerous mammalian species have adapted to the chronic hypoxia of high altitude. Recent genomic studies have identified evidence for natural selection of genes and associated genetic changes in these species. A major gap in our knowledge is an unders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dddbafce093e1613759586fe99c1ad1
https://doi.org/10.1016/j.jbc.2021.100461

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Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains

Autor: Aleksi Sutinen, M. Kristian Koski, Johanna Myllyharju, Juha P. Kallio, Rik K. Wierenga, Peppi Koivunen, Arne Raasakka, Matti Myllykoski

Publikováno v: Journal of Biological Chemistry
The Journal of Biological Chemistry
The journal of biological chemistry 296, 100197 (2021). doi:10.1074/jbc.RA120.016542

The journal of biological chemistry 296, 100197 (2021). doi:10.1074/jbc.RA120.016542
Prolyl 4-hydroxylases (P4Hs) catalyze post-translational hydroxylation of peptidyl proline residues. In addition to collagen P4Hs and hypoxia-inducible factor P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7797ecd49bf354ab2262d9576289a82
https://doi.org/10.1074/jbc.ra120.016542

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Stem cell fate determination through protein O-GlcNAcylation

Autor: Bright Starling Emerald, Muhammad Abid Sheikh, Suraiya A. Ansari

Publikováno v: The Journal of Biological Chemistry

Embryonic and adult stem cells possess the capability of self-renewal and lineage-specific differentiation. The intricate balance between self-renewal and differentiation is governed by developmental signals and cell-type-specific gene regulatory mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e46bbaeb35f21f9e3b8a1455d9c0910
https://doi.org/10.1074/jbc.rev120.014915

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Combining Optical Reporter Proteins with Different Half-lives to Detect Temporal Evolution of Hypoxia and Reoxygenation in Tumors

Autor: Yelena Mironchik, Balaji Krishnamachary, Santosh Kumar Bharti, Zaver M. Bhujwalla, Samata Kakkad, Pierre Danhier

Publikováno v: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 17, Iss 12, Pp 871-881 (2015)

Here we have developed a hypoxia response element driven imaging strategy that combined the hypoxia-driven expression of two optical reporters with different half-lives to detect temporal changes in hypoxia and hypoxia inducible factor (HIF) activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ad3f708ca051464c405ab306bb45b5

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Different evolutionary patterns of hypoxia-inducible factor α (HIF-α) isoforms in the basal branches of Actinopterygii and Sarcopterygii

Autor: Wen Wang, Wuhan Xiao, Wei Chi, Xiaoni Gan, Shunping He

Publikováno v: FEBS Open Bio

Hypoxia-inducible factor (HIF) is a crucial regulator of cellular and systemic responses to low oxygen levels. Here we firstly cloned three HIF-α isoforms from the basal branches of Osteichthyes and used computational tools to characterise the molec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf1e5e044eb999cfb739fbc4c4e033d
https://doi.org/10.1016/j.fob.2013.09.004

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Sequence Analysis and Phylogenetic Studies of Hypoxia-Inducible Factor-1α

Autor: H. G. Nagendra, Jagadeesha Poyya, D. Jagadeesha Kumar, Chandrashekhar G. Joshi

Publikováno v: Cancer Informatics
Cancer Informatics, Vol 16 (2017)

Hypoxia-inducible factors (HIF) belong to the basic helix loop helix–PER ARNT SIM (bHLH-PAS) family of transcription factors that induce metabolic reprogramming under hypoxic condition. The phylogenetic studies of hypoxia-inducible factor-1α (HIF-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b7e3e2b8b3286eeaba20e72ab305ef1
https://pubmed.ncbi.nlm.nih.gov/28615919

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