Zobrazeno 1 - 10 of 256 pro vyhledávání: '"Oxipurinol"'
1
Surface plasmon resonance imaging for detection of drug metabolites in water
Autor: Peter Hausler, Simon Heckscher, Lukas Wunderlich, Rudolf Bierl, Johannes Fischer, Thomas Hirsch, Christina Pfab
Publikováno v: Optical Sensors 2019.
The analysis of surface water, groundwater, drinking water as well as sewage is important to get information about the contamination of the water cycle. Currently, these time-consuming investigations require special equipment, like for example hyphen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c627a933b051f4fb28507455464729df
https://doi.org/10.1117/12.2522324
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2
A simple method for quantification of allopurinol and oxipurinol in human serum by high-performance liquid chromatography with UV-detection
Autor: Eric N. van Roon, Lars C. Nijdam, M.K. Reinders, Mart A F J van de Laar, T.L.Th.A. Jansen, Jacobus R. B. J. Brouwers, Kris L. L. Movig
Publikováno v: Journal of Pharmaceutical and Biomedical Analysis, 45(2), 312-317. ELSEVIER SCIENCE BV
Journal of pharmaceutical and biomedical analysis, 45(2), 312-317. Elsevier
Objectives: Allopurinol is a uric acid lowering drug used in the treatment of gout and the prevention of tumor lysis syndrome. Allopurinol and its active metabolite oxipurinol inhibit xanthine oxidase, which forms uric acid from xanthine and hypoxant
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ed5e1aa376983aa8a5c98eb9054e8b
https://hdl.handle.net/11370/9635cd24-c0f8-4099-bc6f-41357ab62cdb
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3
Akademický článek
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4
Chemical Nature and Reaction Mechanisms of the Molybdenum Cofactor of Xanthine Oxidoreductase
Autor: Teruo Kusano, Ken Okamoto, Takeshi Nishino
Publikováno v: Current Pharmaceutical Design
Xanthine oxidoreductase (XOR), a complex flavoprotein, catalyzes the metabolic reactions leading from hypoxanthine to xanthine and from xanthine to urate, and both reactions take place at the molybdenum cofactor. The enzyme is a target of drugs for t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f986e7605703b394e420ab7e6626da6
https://doi.org/10.2174/1381612811319140010
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7
Lack of effect of hydrochlorothiazide and low-dose aspirin on the renal clearance of urate and oxypurinol after a single dose of allopurinol in normal volunteers
Autor: Sophie L. Stocker, Richard O. Day, Kenneth M. Williams, Daniel Y. Ng, Garry G. Graham
Publikováno v: European Journal of Clinical Pharmacology. 67:709-713
To determine whether low-dose aspirin and hydrochlorothiazide (HCTZ) affect the renal clearance of oxypurinol and/or urate.Healthy volunteers (n = 8) were treated with allopurinol (600 mg, control), and allopurinol (600 mg) co-administered with singl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e5e89a9b0b306b93eabcb625936f11
https://doi.org/10.1007/s00228-010-0963-6
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8
Measurement of urinary oxypurinol by high performance liquid chromatography–tandem mass spectrometry
Autor: Sophie L. Stocker, Jacqueline M. Anderson, Michael E. Franklin, Peter I. Pillans, Andrew J. McLachlan, Paul J. Taylor, Kenneth M. Williams, Richard O. Day
Publikováno v: Journal of Chromatography B. 878:2363-2368
Oxypurinol is the active metabolite of allopurinol which is used to treat hyperuricaemia associated with gout. Both oxypurinol and allopurinol inhibit xanthine oxidase which forms uric acid from xanthine and hypoxanthine. Plasma oxypurinol concentrat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4033f02514587814d949d53d0e83873c
https://doi.org/10.1016/j.jchromb.2010.07.017
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9
Preservation of cardiac contractility after long-term therapy with oxypurinol in post-ischemic heart failure in mice
Autor: Michelle K. Leppo, Ye Tian, Wei Dong Gao, Zhen Tan, Tieying Dai, Xin Zhong
Publikováno v: European Journal of Pharmacology. 621:71-77
Previously, we showed that oral allopurinol increased survival in mice with post-ischemic cardiomyopathy and attributed this outcome to an improvement of excitation-contraction coupling that boosted contractility. In this study, we tested the sustain
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c827f93efeaf924e7f2d6b48fc80d8
https://doi.org/10.1016/j.ejphar.2009.08.033
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10
Mechanism of Inhibition of Xanthine Oxidoreductase by Allopurinol: Crystal Structure of Reduced Bovine Milk Xanthine Oxidoreductase Bound with Oxipurinol
Autor: Emil F. Pai, Ken Okamoto, Takeshi Nishino, Tomoko Nishino, Bryan T. Eger
Publikováno v: Nucleosides, Nucleotides and Nucleic Acids. 27:888-893
Inhibitors of xanthine oxidoreductase block conversion of xanthine to uric acid and are therefore potentially useful for treatment of hyperuricemia or gout. We determined the crystal structure of reduced bovine milk xanthine oxidoreductase complexed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03aef671a4a81bd62020126341ce6912
https://doi.org/10.1080/15257770802146577
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