Výsledky vyhledávání - "Oxidative Phosphorylation/drug effects"

Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma

Publikováno v: Raggi, C, Taddei, M L, Sacco, E, Navari, N, Correnti, M, Piombanti, B, Pastore, M, Campani, C, Pranzini, E, Iorio, J, Lori, G, Lottini, T, Peano, C, Cibella, J, Lewinska, M, Andersen, J B, di Tommaso, L, Viganò, L, Di Maira, G, Madiai, S, Ramazzotti, M, Orlandi, I, Arcangeli, A, Chiarugi, P & Marra, F 2021, ' Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma ', Journal of Hepatology, vol. 74, no. 6, pp. 1373-1385 . https://doi.org/10.1016/j.jhep.2020.12.031

BACKGROUND & AIMS: Little is known about the metabolic regulation of cancer stem cells (CSCs) in cholangiocarcinoma (CCA). We analyzed whether mitochondrial-dependent metabolism and related signaling pathways contribute to stemness in CCA.METHODS: Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef501d3fbda1682299d6ec0832b7ea5
https://doi.org/10.1016/j.jhep.2020.12.031

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The antibiotic doxycycline impairs cardiac mitochondrial and contractile function

Autor: Diederik W. D. Kuster, Michel van Weeghel, Vida Alizadeh Tazehkandi, Luciënne Baks-Te Bulte, Gustav J. Strijkers, Bram F. Coolen, Ntsiki M. Held, Bianca J. J. M. Brundel, Riekelt H. Houtkooper, Mariah R R Daal, Marit Wiersma, Rob C. I. Wüst

Publikováno v: Wüst, R C I, Coolen, B F, Held, N M, Daal, M R R, Tazehkandi, V A, Baks-Te Bulte, L, Wiersma, M, Kuster, D W D, Brundel, B J J M, van Weeghel, M, Strijkers, G J & Houtkooper, R H 2021, ' The antibiotic doxycycline impairs cardiac mitochondrial and contractile function ', International Journal of Molecular Sciences, vol. 22, no. 8, 4100 . https://doi.org/10.3390/ijms22084100
International journal of molecular sciences, 22(8):4100. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, 22(8):4100, 1-19. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
Volume 22
Issue 8
Wüst, R C I, Coolen, B F, Held, N M, Daal, M R R, Tazehkandi, V A, Baks-Te Bulte, L, Wiersma, M, Kuster, D W D, Brundel, B J J M, van Weeghel, M, Strijkers, G J & Houtkooper, R H 2021, ' The antibiotic doxycycline impairs cardiac mitochondrial and contractile function ', International Journal of Molecular Sciences, vol. 22, no. 8, 4100, pp. 1-19 . https://doi.org/10.3390/ijms22084100
International Journal of Molecular Sciences, 22(8):4100. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 22, Iss 4100, p 4100 (2021)

Tetracycline antibiotics act by inhibiting bacterial protein translation. Given the bacterial ancestry of mitochondria, we tested the hypothesis that doxycycline—which belongs to the tetracycline class—reduces mitochondrial function, and results

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba143ec8e34cf744f53dea11e2bd5101
https://doi.org/10.3390/ijms22084100

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Metabolic reprogramming of host cells upon bacterial infection: Why shift to a Warburg‐like metabolism?

Autor: Carmen Buchrieser, Pedro Escoll

Publikováno v: FEBS Journal
FEBS Journal, 2018, 285 (12), pp.2146-2160. ⟨10.1111/febs.14446⟩
FEBS Journal, Wiley, 2018, 285 (12), pp.2146-2160. ⟨10.1111/febs.14446⟩

This article also appears in: State-of-the-Art Reviews; International audience; The finding that the Warburg effect observed in proliferating cancer cells is also observed during immune responses renewed the interest in the study of metabolic reprogr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b01318b8ed1f263989efedcefb6c55c
https://hal-pasteur.archives-ouvertes.fr/pasteur-02437195

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Disruption of oxidative phosphorylation (OXPHOS) by hydroxylated polybrominated diphenyl ethers (OH-PBDEs) present in the marine environment

Autor: Lillemor Asplund, Juliette Legler, Anna-Karin Dahlberg, P.H. Cenijn, Göran Marsh, Jessica Legradi, Åke Bergman

Publikováno v: Legradi, J, Dahlberg, A-K, Cenijn, P, Marsh, G, Asplund, L, Bergman, Å & Legler, J 2014, ' Disruption of oxidative phosphorylation (OXPHOS) by hydroxylated polybrominated diphenyl ethers (OH-PBDEs) present in the marine environment ', Environmental Science and Technology, vol. 48, no. 24, pp. 14703-11 . https://doi.org/10.1021/es5039744
Environmental Science and Technology, 48(24), 14703-11. American Chemical Society

Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) are of growing concern, as they have been detected in both humans and wildlife and have been shown to be toxic. Recent studies have indicated that OH-PBDEs can be more toxic than PBDEs, partly du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa8f142501b767dce771b3a7e778ad1
https://hdl.handle.net/1871.1/a95da2c9-7b7d-4824-a324-d3113ddd967c

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Postconditioning with cyclosporine a reduces early renal dysfunction by inhibiting mitochondrial permeability transition

Autor: Sandrine Lemoine, Bruno Pillot, Maud Rayberin, Nicolas Rognant, Lionel Augeul, Michel Ovize, Maurice Laville, Annie Varennes, Laurent Juillard

Publikováno v: Transplantation
Transplantation, Lippincott, Williams & Wilkins, 2015, 99 (4), pp.717-23. ⟨10.1097/TP.0000000000000530⟩

International audience; BACKGROUND: Ischemia-reperfusion (IR) injury leads to mitochondrial permeability transition pore opening, which contributes to cell death. The aim of this study is to determine whether ischemic or pharmacological postcondition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e0b4c135f048d83fdcf49de12d602b
https://pubmed.ncbi.nlm.nih.gov/25793558

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Fluoride curcumin derivatives: new mitochondrial uncoupling agents

Autor: Didier Morin, Serge Labidalle, Pierre-Alain Carrupt, Sophie Barthélémy, Jean-Paul Tillement, Heidi Ligeret, Geraldine Bouchard Doulakas

Publikováno v: FEBS Letters, Vol. 569, No 1-3 (2004) pp. 37-42

The mitochondrial effects of two fluoride curcumin derivatives were studied. They induced the collapse of mitochondrial membrane potential (DeltaPsi), increased mitochondrial respiration, and decreased O(2)*- production and promoted Ca(2+) release. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d7c19108684d5ab67b94bfeaee07711
https://archive-ouverte.unige.ch/unige:10599

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Trimetazidine reverses calcium accumulation and impairment of phosphorylation induced by cyclosporine A in isolated rat liver mitochondria

Autor: Salducci, M. D., Chauvet-Monges, A. M., Tillement, J. P., Albengres, E., Testa, Bernard, Carrupt, Pierre-Alain, Crevat, A.

Publikováno v: Journal of Pharmacology and Experimental Therapeutics, Vol. 277, No 1 (1996) pp. 417-422

When applied to rat liver mitochondria in contact with Ca++, cyclosporine A (CsA) induced both an accumulation of this ion and a decrease in oxidative phosphorylation. Trimetazidine (TMZ) reversed both phenomena in a dose-dependent manner. These two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::760e37059d9109fc368c384956aa9a0c
https://pubmed.ncbi.nlm.nih.gov/8613950

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