Sustained delivery of a heterodimer bone morphogenetic protein-2/7 via a collagen hydroxyapatite scaffold accelerates and improves critical femoral defect healing.

Autor: Liu Y; The Faculty of Medicine, Department of Clinical Sciences Lund, Orthopedics, Lund University, BMC C12, Klinikgatan 28, Lund 221 84, Sweden., Puthia M; The Faculty of Medicine, Division of Dermatology and Venerology, Lund University, Lund 221 84, Sweden., Sheehy EJ; Tissue Engineering Research Group, Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, 123 St. Stephens Green, Dublin, Ireland; Advanced Materials & Bioengineering Research (AMBER) Centre, RCSI, 123 St. Stephen's Green, Dublin 2, Ireland; Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Ambite I; The Faculty of Medicine, Department of Laboratory Medicine, Division of Microbiology, Immunology and Glycobiology, Lund University, Lund 221 84, Sweden., Petrlova J; The Faculty of Medicine, Division of Dermatology and Venerology, Lund University, Lund 221 84, Sweden., Prithviraj S; Department of Clinical Sciences Lund, Stem Cell Centre, Cell, Tissue & Organ Engineering Laboratory, Lund University, BMC B11, Lund 221 84, Sweden; Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden., Oxborg MW; The Faculty of Medicine, Department of Clinical Sciences Lund, Orthopedics, Lund University, BMC C12, Klinikgatan 28, Lund 221 84, Sweden., Sebastian S; The Faculty of Medicine, Department of Clinical Sciences Lund, Orthopedics, Lund University, BMC C12, Klinikgatan 28, Lund 221 84, Sweden., Vater C; Trauma and Plastic Surgery, University Hospital Carl Gustav Carus at Technische Universität Dresden, University Center of Orthopedics, Dresden 01307, Germany., Zwingenberger S; Trauma and Plastic Surgery, University Hospital Carl Gustav Carus at Technische Universität Dresden, University Center of Orthopedics, Dresden 01307, Germany., Struglics A; The Faculty of Medicine, Department of Clinical Sciences Lund, Orthopedics, Lund University, BMC C12, Klinikgatan 28, Lund 221 84, Sweden., Bourgine PE; Department of Clinical Sciences Lund, Stem Cell Centre, Cell, Tissue & Organ Engineering Laboratory, Lund University, BMC B11, Lund 221 84, Sweden; Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden., O'Brien FJ; Tissue Engineering Research Group, Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, 123 St. Stephens Green, Dublin, Ireland; Advanced Materials & Bioengineering Research (AMBER) Centre, RCSI, 123 St. Stephen's Green, Dublin 2, Ireland; Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Raina DB; The Faculty of Medicine, Department of Clinical Sciences Lund, Orthopedics, Lund University, BMC C12, Klinikgatan 28, Lund 221 84, Sweden. Electronic address: deepak.raina@med.lu.se.

Publikováno v: Acta biomaterialia [Acta Biomater] 2023 May; Vol. 162, pp. 164-181. Date of Electronic Publication: 2023 Mar 24.