Výsledky vyhledávání - "Oxana P Lazarenko"

Akademický článek

Short‐Term Increased Physical Activity During Early Life Affects High‐Fat Diet–Induced Bone Loss in Young Adult Mice

Autor: Jin‐Ran Chen, Oxana P Lazarenko, Eugenia Carvalho, Michael L Blackburn, Kartik Shankar, Umesh D Wankhade, Elisabet Børsheim

Publikováno v: JBMR Plus, Vol 5, Iss 7, Pp n/a-n/a (2021)

ABSTRACT Mechanical stresses associated with physical activity (PA) have beneficial effects on increasing BMD and improving bone quality. However, a high‐fat diet (HFD) and obesity tend to have negative effects on bone, by increasing bone marrow ad

Externí odkaz: https://doaj.org/article/adc9066c8e0a4677b7bffacff41951ac

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Akademický článek

Nox4 Expression Is Not Required for OVX‐Induced Osteoblast Senescence and Bone Loss in Mice

Autor: Jin‐Ran Chen, Oxana P Lazarenko, Haijun Zhao, Umesh D Wankhade, Kim Pedersen, James Watt, Martin J J Ronis

Publikováno v: JBMR Plus, Vol 4, Iss 8, Pp n/a-n/a (2020)

ABSTRACT Estrogen deficiency and aging play critical roles in the pathophysiology of bone as a result of increased oxidative stress. It has been suggested that prevention of NADPH oxidase‐ (Nox‐) dependent accumulation of ROS may be an approach t

Externí odkaz: https://doaj.org/article/81889a3c52414d88a0850a0fb13fdb0e

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Akademický článek

3‐(3‐Hydroxyphenyl)‐Propionic Acid (PPA) Suppresses Osteoblastic Cell Senescence to Promote Bone Accretion in Mice

Autor: Jin‐Ran Chen, Umesh D Wankhade, Alexander W Alund, Michael L Blackburn, Kartik Shankar, Oxana P Lazarenko

Publikováno v: JBMR Plus, Vol 3, Iss 9, Pp n/a-n/a (2019)

ABSTRACT Phenolic acids (PAs) are metabolites derived from polyphenolic compounds found in fruits and vegetables resulting from the actions of gut bacteria. Previously, we reported that the levels of seven individual PAs were found to be at least 10

Externí odkaz: https://doaj.org/article/c2312d3bde714a80baa9957af880f7e7

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Akademický článek

Feeding blueberry diets to young rats dose-dependently inhibits bone resorption through suppression of RANKL in stromal cells.

Autor: Jian Zhang, Oxana P Lazarenko, Jie Kang, Michael L Blackburn, Martin J J Ronis, Thomas M Badger, Jin-Ran Chen

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e70438 (2013)

Previous studies have demonstrated that weanling rats fed AIN-93G semi-purified diets supplemented with 10% whole blueberry (BB) powder for two weeks beginning on postnatal day 21 (PND21) significantly increased bone formation at PND35. However, the

Externí odkaz: https://doaj.org/article/305a9d1620a64717990212baf08df3ea

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Akademický článek

Differential effects of short term feeding of a soy protein isolate diet and estrogen treatment on bone in the pre-pubertal rat.

Autor: Jian Zhang, Oxana P Lazarenko, Xianli Wu, Yudong Tong, Michael L Blackburn, Horatio Gomez-Acevedo, Kartik Shankar, Thomas M Badger, Martin J J Ronis, Jin-Ran Chen

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35736 (2012)

BACKGROUND: Previous reports suggest that beneficial effects of soy on bone quality are due to the estrogenic actions of isoflavone phytochemicals associated with the protein. However, mechanistic studies comparing the effects of soy diet and estroge

Externí odkaz: https://doaj.org/article/c84c8e1118ec48fcb835dfda4eea2475

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Akademický článek

Feeding blueberry diets in early life prevent senescence of osteoblasts and bone loss in ovariectomized adult female rats.

Autor: Jian Zhang, Oxana P Lazarenko, Michael L Blackburn, Kartik Shankar, Thomas M Badger, Martin J J Ronis, Jin-Ran Chen

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24486 (2011)

Appropriate nutrition during early development is essential for maximal bone mass accretion; however, linkage between early nutrition, childhood bone mass, peak bone mass in adulthood, and prevention of bone loss later in life has not been studied.In

Externí odkaz: https://doaj.org/article/1e191c7a082b4f3e97acb95321264c63

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Akademický článek

Obesity reduces bone density associated with activation of PPARγ and suppression of Wnt/β-catenin in rapidly growing male rats.

Autor: Jin-Ran Chen, Oxana P Lazarenko, Xianli Wu, Yudong Tong, Michael L Blackburn, Kartik Shankar, Thomas M Badger, Martin J J Ronis

Publikováno v: PLoS ONE, Vol 5, Iss 10, p e13704 (2010)

BACKGROUND: It is well established that excessive consumption of a high fat diet (HFD) results in obesity; however, the consequences of obesity on postnatal skeletal development have not been well studied. METHODOLOGY AND PRINCIPAL FINDINGS: Total en

Externí odkaz: https://doaj.org/article/93fbef7a6bff4075a54aef9cbade45d1

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Akademický článek

Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice

Autor: Jin-Ran Chen, Perry C. Caviness, Haijun Zhao, Beau Belcher, Umesh D. Wankhade, Kartik Shankar, Michael L Blackburn, Oxana P. Lazarenko

Publikováno v: Epigenetics, Vol 17, Iss 13, Pp 2209-2222 (2022)

Studies from both humans and animal models indicated that maternal chronic poor-quality diet, especially a high fat diet (HFD), is significantly associated with reduced bone density and childhood fractures in offspring. When previously studied in a r

Externí odkaz: https://doaj.org/article/1331f72c52864306a9d5a2a5e1c5464f

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