Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Oxana Doroshyenko"'
Autor:
Usman Arshad, Alexander Jetter, Sami Ullah, Su-arpa Ploylearmsaeng, Semih A. Güner, Uwe Fuhr, Edgar Schömig, Ulrich Jaehde, Mats O. Karlsson, Max Taubert, Sabine Kunze, Oxana Doroshyenko, Dorothee Langer, Roman Skripnichenko
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose To describe 5-fluorouracil (5FU) pharmacokinetics, myelotoxicity and respective covariates using a simultaneous nonlinear mixed effect modelling approach. Methods Thirty patients with gastrointestinal cancer received 5FU 650 or 1000 mg/m2/day
Autor:
Nico Watzek, Franz Berger, Matthias Baum, Gerhard Eisenbrand, Uwe Fuhr, Dorota Tomalik-Scharte, Julia Feld, Elke Richling, Oxana Doroshyenko, Denise Scherbl
Publikováno v:
Molecular Nutrition & Food Research. 56:1825-1837
Scope Acrolein (AC) and acrylamide (AA) are food contaminants generated by heat treatment. We studied human exposure after consumption of potato crisps by monitoring excretion of mercapturic acids (MAs) in urine. Methods and results MA excretion was
Publikováno v:
Clinical Pharmacokinetics. 50:371-403
The 4-anilinoquinazolines (gefitinib, erlotinib and lapatinib) are members of a class of potent and selective inhibitors of the human epidermal growth factor receptor (HER) family of tyrosine kinases that have been developed to treat patients with tu
Autor:
D Frank, Julia C. Stingl, Oxana Doroshyenko, Dorota Tomalik-Scharte, Martin Hellmich, Uwe Fuhr, Alexander Jetter
Publikováno v:
Drug Metabolism and Disposition. 39:927-932
The pharmacokinetics of repaglinide shows pronounced interindividual variability, for which several reasons have been considered, including interactions with drugs inhibiting CYP2C8 and CYP2C8 genetic polymorphism. However, existing data on the role
Autor:
Tobias Klaassen, Wolfgang Hein, Gerd Fätkenheuer, Julia Kirchheiner, D Frank, Angela Seeringer, Alexander Jetter, Christoph Wyen, Edgar Schömig, Uwe Fuhr, Oxana Doroshyenko
Publikováno v:
Antiviral Therapy. 15:975-983
Background In inflammation and infection, cytochrome P450 (CYP) enzyme activities are down-regulated. Information on possible discrepancies in activities of CYP enzymes and drug transporters between HIV-infected patients and healthy people is limited
Autor:
Dieter Lütjohann, Dorota Tomalik-Scharte, D Frank, Oxana Doroshyenko, Alexander Jetter, Uwe Fuhr
Publikováno v:
Clinical Pharmacology & Therapeutics. 86:147-153
We assessed the suitability of 4beta-hydroxycholesterol (4betaOH-C) as an endogenous cytochrome P450 3A (CYP3A) phenotyping metric. 4betaOH-C and its ratio to cholesterol (4betaOH-C/C) were determined in five cocktail phenotyping studies, with and wi
Autor:
Alexander Jetter, Martina Kinzig-Schippers, Verena Jakob, Uwe Fuhr, Bernhard Scheidel, Ingolf Cascorbi, Oxana Doroshyenko, Michael Rodamer, Fritz Sörgel, Dorota Tomalik-Scharte
Publikováno v:
Antimicrobial Agents and Chemotherapy. 49:1733-1738
Isoniazid is metabolized by the genetically polymorphic arylamine N -acetyltransferase type 2 (NAT2). A greater number of high-activity alleles are related to increased acetylation capacity and in some reports to low efficacy and toxicity of isoniazi
Autor:
Christian Queckenberg, Oxana Doroshyenko, Bertil Wachall, Dorota Tomalik-Scharte, Jürgen Meins, Uwe Fuhr, Bärbel Bastian, Mona Abdel-Tawab
Publikováno v:
Web of Science
We evaluated the pharmacokinetics and safety of the antimicrobial agent triclosan after dermal application of a 2% triclosan-containing cream to six volunteers. Percutaneous absorption calculated from urinary excretion was 5.9% ± 2.1% of the dose (m
Autor:
G Zadoyan, Thomas Gramatté, Dennis Rokitta, Angelika Dienel, Oxana Doroshyenko, Sandra Schläfke, Uwe Fuhr, Hendrik Lück, Stephan Klement
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 41(5)
This cocktail study evaluated the interaction potential of the oral lavender oil preparation silexan with major P450 (cytochrome P450) enzymes. Subjects and Methods: Sixteen healthy male or female Caucasians completed this double-blind, randomized, 2
Autor:
Oxana Doroshyenko, Uwe Fuhr
Publikováno v:
Clinical pharmacokinetics. 48(5)
The succinate salt of solifenacin, a tertiary amine with anticholinergic properties, is used for symptomatic treatment of overactive bladder. Solifenacin peak plasma concentrations of 24.0 and 40.6 ng/mL are reached 3-8 hours after long-term oral adm