Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Oxana Dobrovinskaya"'
Autor:
Igor Pottosin, Oxana Dobrovinskaya
Publikováno v:
Stress Biology, Vol 2, Iss 1, Pp 1-12 (2022)
Abstract Two-pore cation channel, TPC1, is ubiquitous in the vacuolar membrane of terrestrial plants and mediates the long distance signaling upon biotic and abiotic stresses. It possesses a wide pore, which transports small mono- and divalent cation
Externí odkaz:
https://doaj.org/article/a2b647f8f9684c12af4dc3d2269598d3
Publikováno v:
Cells, Vol 12, Iss 20, p 2486 (2023)
Modulation of autophagy as an anticancer strategy has been widely studied and evaluated in several cell models. However, little attention has been paid to the metabolic changes that occur in a cancer cell when autophagy is inhibited or induced. In th
Externí odkaz:
https://doaj.org/article/04ddbca83f114a84a41262836e115d65
Publikováno v:
Cells, Vol 12, Iss 16, p 2065 (2023)
Degranulation mediated killing mechanism by NK cells is dependent on store-operated Ca2+ entry (SOCE) and has optimum at moderate intracellular Ca2+ elevations so that partial block of SOCE optimizes the killing process. In this study, we tested the
Externí odkaz:
https://doaj.org/article/0f6075c8d7b245f0a6960e22af3f35fe
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The G-protein–coupled estrogen receptor (GPER) mediates non-genomic action of estrogen. Due to its differential expression in some tumors as compared to the original healthy tissues, the GPER has been proposed as a therapeutic target. Accordingly,
Externí odkaz:
https://doaj.org/article/d278ba9d06cc4828a44797c25df68a02
Publikováno v:
Cellular Physiology and Biochemistry, Vol 54, Iss 5, Pp 842-852 (2020)
Externí odkaz:
https://doaj.org/article/eac031eb21f745ae8e35c5d272d00e18
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Glucocorticoids (GCs) are a central component of multi-drug treatment protocols against T and B acute lymphoblastic leukemia (ALL), which are used intensively during the remission induction to rapidly eliminate the leukemic blasts. The primary respon
Externí odkaz:
https://doaj.org/article/fdbc6b34075a43adbc21245b8937c3b8
Publikováno v:
Frontiers in Plant Science, Vol 11 (2021)
This work critically discusses the direct and indirect effects of natural polyamines and their catabolites such as reactive oxygen species and γ-aminobutyric acid on the activity of key plant ion-transporting proteins such as plasma membrane H+ and
Externí odkaz:
https://doaj.org/article/db065657a14c4a34af3b43d87b92f652
Autor:
Miguel Olivas-Aguirre, Liliana Torres-López, Kathya Villatoro-Gómez, Sonia Mayra Perez-Tapia, Igor Pottosin, Oxana Dobrovinskaya
Publikováno v:
Pharmaceuticals, Vol 15, Iss 3, p 366 (2022)
Cannabidiol (CBD), a major non-psychotropic component of cannabis, is receiving growing attention as a potential anticancer agent. CBD suppresses the development of cancer in both in vitro (cancer cell culture) and in vivo (xenografts in immunodefici
Externí odkaz:
https://doaj.org/article/6624975dd94b45e98e3211d949a6189d
Autor:
Miguel Olivas-Aguirre, Liliana Torres-López, Zeferino Gómez-Sandoval, Kathya Villatoro-Gómez, Igor Pottosin, Oxana Dobrovinskaya
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8688 (2021)
Cytotoxic effects of cannabidiol (CBD) and tamoxifen (TAM) have been observed in several cancer types. We have recently shown that CBD primarily targets mitochondria, inducing a stable mitochondrial permeability transition pore (mPTP) and, consequent
Externí odkaz:
https://doaj.org/article/8b90291957a049beb13df0fda3c2e3f3
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 204 (2020)
Anticancer activity of different phenols is documented, but underlying mechanisms remain elusive. Recently, we have shown that cannabidiol kills the cells of acute lymphoblastic leukemia (ALL) by a direct interaction with mitochondria, with their con
Externí odkaz:
https://doaj.org/article/790c4e8579e04ff5a9419db09748dee5