Zobrazeno 1 - 10
of 4 589
pro vyhledávání: '"OxPhos"'
Autor:
Dongqing Cui, Haixia Liu, Lili Cao, Xiaowei Du, Dingxin Liu, Zhiping Liu, Tong Wang, Hui Yang, Xiaolei Zheng, Zhaohong Xie, Shunliang Xu, Jianzhong Bi, Ping Wang
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-30 (2024)
Abstract Background Alzheimer's disease (AD) is a prevalent irreversible neurodegenerative condition marked by gradual cognitive deterioration and neuronal loss. The mammalian Ste20-like kinase (MST1)–Hippo pathway is pivotal in regulating cell apo
Externí odkaz:
https://doaj.org/article/bc44250feb434892a33fd1240e06dd29
Autor:
Laura Schmitt, Karina S. Krings, Andre Wolsing, Xabier Buque, Marcel Zimmermann, Hector Flores-Romero, Thomas Lenz, Ilka Lechtenberg, Christoph Peter, Björn Stork, Nicole Teusch, Peter Proksch, Kai Stühler, Ana J. García-Sáez, Andreas S. Reichert, Patricia Aspichueta, Sanil Bhatia, Sebastian Wesselborg
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-22 (2024)
Abstract Targeting mitochondrial metabolism represents a promising approach for cancer treatment. Here, we investigated the mitotoxic potential of the polybrominated diphenyl ether bromoxib, a natural compound isolated from the marine sponge Dysidea
Externí odkaz:
https://doaj.org/article/9172168f3c784c2f8b3a4f970bd907a9
Publikováno v:
Egyptian Journal of Medical Human Genetics, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background Mitochondrial DNA variants are significant contributors to cancer progression, as evidenced by numerous findings. This study focuses on characterizing mitochondrial DNA mutations in colorectal cancer progression and their potentia
Externí odkaz:
https://doaj.org/article/0fb1df562d694b4b980baffb3644c3fe
Autor:
Hassan A. Ali, Joanna M. Karasinska, James T. Topham, Danisha Johal, Steve Kalloger, Andrew Metcalfe, Cassia S. Warren, Anthony Miyagi, Lan V. Tao, Maya Kevorkova, Shawn C. Chafe, Paul C. McDonald, Shoukat Dedhar, Seth J. Parker, Daniel J. Renouf, David F. Schaeffer
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-13 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease characterized by complex metabolic rewiring that enables growth in changing nutrient availability and oxygen conditions. Transcriptome-based prognostic PDAC tu
Externí odkaz:
https://doaj.org/article/a2c84c9d9241460d889b4c891a5bea32
Publikováno v:
Genes and Environment, Vol 46, Iss 1, Pp 1-12 (2024)
Abstract Background Poly(ADP-ribose) polymerase-1 (PARP-1) is a pan nuclear protein that utilizes NAD+ as a substrate for poly(ADP-ribosyl)ation reaction (PARylation), resulting in both auto-modification and the modification of its accepter proteins.
Externí odkaz:
https://doaj.org/article/06288f3351124349ae573102532c09e2
Autor:
Xiaodong Li, Jingjing Tie, Yuze Sun, Chengrong Gong, Shizhou Deng, Xiyu Chen, Shujiao Li, Yaoliang Wang, Zhenhua Wang, Feifei Wu, Hui Liu, Yousheng Wu, Guopeng Zhang, Qingdong Guo, Yanling Yang, Yayun Wang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-34 (2024)
Abstract Background The dynamics of mitochondrial respiratory cristae (MRC) and its impact on oxidative phosphorylation (OXPHOS) play a crucial role in driving the progression of high-grade glioma (HGG). However, the underlying mechanism remains uncl
Externí odkaz:
https://doaj.org/article/56bb953149df4c158b95e18a344471d9
Publikováno v:
Journal of Inflammation Research, Vol Volume 17, Pp 6645-6659 (2024)
Zhaochang Jiang,1 Haohao Lu,2 Beibei Gao,3 Jinyu Huang,3 Yu Ding4 1Department of Pathology, Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang, 310009, People’s Republic of China; 2Zhejiang Center of Laborator
Externí odkaz:
https://doaj.org/article/02d4f7920642490dbd1fdcdf33a11fdb
Autor:
Qiyu Dong, Xiaojie Yin, Shuanglong Fan, Sheng Zhong, Wenxin Yang, Keer Chen, Qian Wang, Xue Ma, Refiloe Laurentinah Mahlatsi, Yanling Yang, Jianxin Lyu, Hezhi Fang, Ya Wang
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract Background Leigh syndrome (LS) is a common mitochondrial disease caused by mutations in both mitochondrial and nuclear genes. Isoleucyl-tRNA synthetase 2 (IARS2) encodes mitochondrial isoleucine-tRNA synthetase, and variants in IARS2 have be
Externí odkaz:
https://doaj.org/article/e0dc0c332a5b4c46a0d697210083b4e3
Autor:
Iresha Subhasinghe, Khawaja Ashfaque Ahmed, Lisanework E. Ayalew, Hemlata Gautam, Shelly Popowich, Ayumi Matsuyama-Kato, Betty Chow-Lockerbie, Suresh K. Tikoo, Philip Griebel, Susantha Gomis
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Oligodeoxynucleotides containing CpG motifs (CpG-ODN) can promote antimicrobial immunity in chickens by enriching immune compartments and activating immune cells. Innate memory, or trained immunity, has been demonstrated in humans and mice,
Externí odkaz:
https://doaj.org/article/afe11101d1254218a19debb706f0c963
Autor:
Mariam M. Konaté, Julia Krushkal, Ming-Chung Li, Li Chen, Yuri Kotliarov, Alida Palmisano, Rini Pauly, Qian Xie, P. Mickey Williams, Lisa M. McShane, Yingdong Zhao
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background With poor prognosis and high mortality, pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies. Standard of care therapies for PDAC have included gemcitabine for the past three decades, although resistance
Externí odkaz:
https://doaj.org/article/8450290fb1bd45a187afecbd4534732f