Pharmacogenetic and clinical risk factors for bevacizumab-related gastrointestinal hemorrhage in prostate cancer patients treated on CALGB 90401 (Alliance).

Autor: Patel JN; Department of Cancer Pharmacology & Pharmacogenomics, Atrium Health Levine Cancer Institute, Charlotte, NC, USA. jai.patel@atriumhealth.org., Jiang C; Alliance Statistics and Data Management Center, Duke University, Durham, NC, USA., Owzar K; Alliance Statistics and Data Management Center, Duke University, Durham, NC, USA.; Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA., Hertz DL; Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, USA., Wang J; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Mulkey FA; Alliance Statistics and Data Management Center, Duke University, Durham, NC, USA., Kelly WK; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA., Halabi S; Alliance Statistics and Data Management Center, Duke University, Durham, NC, USA.; Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA., Furukawa Y; Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Lassiter C; University of Maryland School of Nursing (Miltenyi Biotech at time of publication), Baltimore, MD, USA., Dorsey SG; University of Maryland School of Nursing (Miltenyi Biotech at time of publication), Baltimore, MD, USA., Friedman PN; Department of Pharmacology and Center for Pharmacogenomics, Northwestern University, Evanston, IL, USA., Small EJ; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Carducci MA; Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Kelley MJ; Durham VA Medical Center/Duke University Medical Center, Durham, NC, USA., Nakamura Y; Center for Personalized Therapeutics, University of Chicago (Japanese Foundation for Cancer Research, Ariake, Tokyo at time of publication), Chicago, IL, USA., Kubo M; Riken Center for Integrative Medical Sciences (Haradoi Hospital, Fukuoka, Japan at time of publication), Kanagawa, Japan., Ratain MJ; Center for Personalized Therapeutics, University of Chicago (Japanese Foundation for Cancer Research, Ariake, Tokyo at time of publication), Chicago, IL, USA., Morris MJ; Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., McLeod HL; Utah Tech University, St. George, UT, USA.

Publikováno v: The pharmacogenomics journal [Pharmacogenomics J] 2024 Mar 04; Vol. 24 (2), pp. 6. Date of Electronic Publication: 2024 Mar 04.

Single Cell Expression Analysis of Ductal Carcinoma in Situ Identifies Complex Genotypic-Phenotypic Relationships Altering Epithelial Composition.

Autor: Qin X, Strand SH, Lee MR, Saraswathibhatla A, van IJzendoorn DGP, Zhu C, Vennam S, Varma S, Hall A, Factor RE, King L, Simpson L, Luo X, Colditz GA, Jiang S, Chaudhuri O, Hwang ES, Marks JR, Owzar K, West RB

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 25. Date of Electronic Publication: 2024 Sep 25.

Analysis of ductal carcinoma in situ by self-reported race reveals molecular differences related to outcome.

Autor: Strand SH; Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA., Houlahan KE; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Department of Medicine, Genetics, Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, 94305, USA., Branch V; National Breast Cancer Coalition, 2001 L Street NW, Suite 500 PMB#50111, Washington, DC, 20036, USA., Lynch T; Department of Surgery, Duke University School of Medicine, Durham, NC, 27708, USA., Rivero-Guitiérrez B; Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA., Harmon B; Department of Pathology, Montefiore Medical Center, New York City, NY, USA., Couch F; Department of Pathology, Mayo Clinic, Rochester, MN, USA., Gallagher K; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Kilgore M; Department of Pathology, University of Washington, Seattle, WA, USA., Wei S; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA., DeMichele A; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA., King T; Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA., McAuliffe P; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Curtis C; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Department of Medicine, Genetics, Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, 94305, USA., Owzar K; Duke Cancer Institute, Duke University School of Medicine, Durham, NC, 27708, USA.; Department of Biostatistics & Bioinformatics, Duke University School of Medicine, Durham, NC, 27708, USA., Marks JR; Department of Surgery, Duke University School of Medicine, Durham, NC, 27708, USA., Colditz GA; Department of Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA., Hwang ES; Department of Surgery, Duke University School of Medicine, Durham, NC, 27708, USA., West RB; Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA. rbwest@stanford.edu.

Publikováno v: Breast cancer research : BCR [Breast Cancer Res] 2024 Sep 02; Vol. 26 (1), pp. 127. Date of Electronic Publication: 2024 Sep 02.

Common variation in a long non-coding RNA gene modulates variation of circulating TGF-β2 levels in metastatic colorectal cancer patients (Alliance).

Autor: Quintanilha JCF; UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Sibley AB; Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA., Liu Y; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Niedzwiecki D; Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA.; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA.; Alliance Statistics and Data Management Center, Duke University, Durham, NC, USA., Halabi S; Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA.; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA.; Alliance Statistics and Data Management Center, Duke University, Durham, NC, USA., Rogers L; Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA., O'Neil B; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN, USA., Kindler H; Department of Medicine, The University of Chicago, Chicago, IL, USA., Kelly W; Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA., Venook A; Department of Medicine, University of California at San Francisco, San Francisco, CA, USA., McLeod HL; University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Utah Tech University, St George, UT, USA., Ratain MJ; Department of Medicine, The University of Chicago, Chicago, IL, USA., Nixon AB; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Innocenti F; Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Owzar K; Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA. kouros.owzar@duke.edu.; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA. kouros.owzar@duke.edu.; Alliance Statistics and Data Management Center, Duke University, Durham, NC, USA. kouros.owzar@duke.edu.

Publikováno v: BMC genomics [BMC Genomics] 2024 May 14; Vol. 25 (1), pp. 473. Date of Electronic Publication: 2024 May 14.

The TLR2/TLR6 ligand FSL-1 mitigates radiation-induced hematopoietic injury in mice and nonhuman primates.

Autor: Brickey WJ; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Lineberger Comprehensive Cancer Center, Center of Translational Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Caudell DL; Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157., Macintyre AN; Duke Human Vaccine Institute, Department of Medicine, Duke University School of Medicine, Durham, NC 27710., Olson JD; Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157., Dai Y; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC 27705., Li S; Lineberger Comprehensive Cancer Center, Center of Translational Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Dugan GO; Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157., Bourland JD; Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157., O'Donnell LM; Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157., Tooze JA; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston Salem, NC 27157., Huang G; Lineberger Comprehensive Cancer Center, Center of Translational Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Yang S; Lineberger Comprehensive Cancer Center, Center of Translational Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Guo H; Lineberger Comprehensive Cancer Center, Center of Translational Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., French MN; Duke Human Vaccine Institute, Department of Medicine, Duke University School of Medicine, Durham, NC 27710., Schorzman AN; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Zamboni WC; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Sempowski GD; Duke Human Vaccine Institute, Department of Medicine, Duke University School of Medicine, Durham, NC 27710., Li Z; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC 27705.; Duke Cancer Institute, Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC 27705., Owzar K; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC 27705.; Duke Cancer Institute, Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC 27705., Chao NJ; Department of Medicine, Duke University School of Medicine, Durham, NC 27705., Cline JM; Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157., Ting JPY; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Lineberger Comprehensive Cancer Center, Center of Translational Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Dec 12; Vol. 120 (50), pp. e2122178120. Date of Electronic Publication: 2023 Dec 05.