Hypoxia extends lifespan and neurological function in a mouse model of aging.

Autor: Rogers RS; Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Broad Institute, Cambridge, Massachusetts, United States of America.; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America., Wang H; Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Broad Institute, Cambridge, Massachusetts, United States of America.; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America., Durham TJ; Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Broad Institute, Cambridge, Massachusetts, United States of America.; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America., Stefely JA; Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Broad Institute, Cambridge, Massachusetts, United States of America.; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America., Owiti NA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America., Markhard AL; Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Broad Institute, Cambridge, Massachusetts, United States of America.; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America., Sandler L; Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Broad Institute, Cambridge, Massachusetts, United States of America.; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America., To TL; Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Broad Institute, Cambridge, Massachusetts, United States of America.; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America., Mootha VK; Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Broad Institute, Cambridge, Massachusetts, United States of America.; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America.

Publikováno v: PLoS biology [PLoS Biol] 2023 May 23; Vol. 21 (5), pp. e3002117. Date of Electronic Publication: 2023 May 23 (Print Publication: 2023).

Using the HepaCometChip Assay for Broad-Spectrum DNA Damage Analysis.

Autor: Owiti NA; Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts., Kaushal S; Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts., Martin L; Integrated Laboratory Systems, Inc. (ILS), Research Triangle Park, North Carolina., Sly J; Integrated Laboratory Systems, Inc. (ILS), Research Triangle Park, North Carolina., Swartz CD; Integrated Laboratory Systems, Inc. (ILS), Research Triangle Park, North Carolina., Fowler J; Integrated Laboratory Systems, Inc. (ILS), Research Triangle Park, North Carolina., Corrigan JJ; Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts., Recio L; Integrated Laboratory Systems, Inc. (ILS), Research Triangle Park, North Carolina., Engelward BP; Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts.

Publikováno v: Current protocols [Curr Protoc] 2022 Sep; Vol. 2 (9), pp. e563.

Sensitive CometChip assay for screening potentially carcinogenic DNA adducts by trapping DNA repair intermediates.

Autor: Ngo LP; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Owiti NA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Swartz C; Toxicology Program, Integrated Laboratory Systems, Inc., Research Triangle Park, NC 27560, USA., Winters J; Toxicology Program, Integrated Laboratory Systems, Inc., Research Triangle Park, NC 27560, USA., Su Y; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Ge J; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Xiong A; BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology, 138602 Singapore., Han J; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology, 138602 Singapore.; Department of Electrical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Recio L; Toxicology Program, Integrated Laboratory Systems, Inc., Research Triangle Park, NC 27560, USA., Samson LD; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Engelward BP; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2020 Feb 20; Vol. 48 (3), pp. e13.