Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Owen W J, Prall"'
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Akademický článek
Immune and genomic biomarkers of immunotherapy response in cancer of unknown primary
Autor: Madhu Singh, Linda Mileshkin, Penelope Schofield, Bo Gao, Gary Richardson, Andrew Pattison, Rodney J Hicks, Niko Thio, Mark Warren, Colin Wood, Stephen B Fox, Anna DeFazio, Andrew Fellowes, Christopher Steer, David Bowtell, Nicholas Wilcken, Tharani Sivakumaran, Atara Posner, Dariush Etemadmoghadam, Krista Fisher, Samantha Webb, Christos S Karapetis, Ian M Collins, Narayan Karanth, Owen W J Prall, Richard William Tothill
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 1 (2023)
Background Cancer of unknown primary (CUP) is a heterogeneous group of metastatic cancers where a primary tissue of origin (TOO) is uncertain. Most patients with CUP have limited treatment options and poor survival outcomes. Immune checkpoint inhibit
Externí odkaz: https://doaj.org/article/62a3f3bb406f4f688c1bd4d184af4202
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2
Tumor-Infiltrating Neutrophils after Neoadjuvant Therapy are Associated with Poor Prognosis in Esophageal Cancer
Autor: Carlos S. Cabalag, Owen W. J. Prall, John Ciciulla, Laurence A. Galea, Niko Thio, Madawa Jayawardana, Trishe Y. M. Leong, Julia V. Milne, Kenji M. Fujihara, Lynn Chong, Michael W. Hii, Gisela Mir Arnau, Paul J. Neeson, Wayne A. Phillips, Cuong P. Duong, Nicholas J. Clemons
Publikováno v: Annals of Surgical Oncology. 30:1614-1625
Background In esophageal cancer (EC), there is a paucity of knowledge regarding the interplay between the tumor immune microenvironment and response to neoadjuvant treatment and, therefore, which factors may influence outcomes. Thus, our goal was to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::935613760b2860f468023539fcb53bff
https://doi.org/10.1245/s10434-022-12562-5
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6
A MXI1-NUTM1 fusion protein with MYC-like activity suggests a novel oncogenic mechanism in a subset of NUTM1-rearranged tumors
Autor: Christopher R, McEvoy, Holly, Holliday, Niko, Thio, Catherine, Mitchell, David Y, Choong, Bhargavi, Yellapu, Hui San, Leong, Huiling, Xu, Stephen, Lade, Judy, Browning, Elena A, Takano, David J, Byrne, Anthony J, Gill, Cuong P, Duong, Jason, Li, Andrew P, Fellowes, Stephen B, Fox, Alexander, Swarbrick, Owen W J, Prall
Publikováno v: Laboratory investigation; a journal of technical methods and pathology. 101(1)
Most NUTM1-rearranged neoplasms (NRNs) have fusions between NUTM1 and BRD (bromodomain-containing) family members and are termed NUT carcinomas (NCs) because they show some squamous differentiation. However, some NRNs are associated with fusions betw
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::246d1faae91be0e5ab0e4939cfc54850
https://pubmed.ncbi.nlm.nih.gov/32873880
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8
Insulin/Insulin-like Growth Factor-I and Estrogen Cooperate to Stimulate Cyclin E-Cdk2 Activation and Cell Cycle Progression in MCF-7 Breast Cancer Cells through Differential Regulation of Cyclin E and p21WAF1/Cip1
Autor: Robert L. Sutherland, Angela Lai, Boris Sarcevic, Owen W. J. Prall
Publikováno v: Journal of Biological Chemistry. 276:25823-25833
Estrogens and insulin/insulin-like growth factor-I (IGF-I) are potent mitogens for breast epithelial cells and, when co-administered, induce synergistic stimulation of cell proliferation. To investigate the molecular basis of this effect, a MCF-7 bre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b76e3c4069678c2fe42fe25ab78043
https://doi.org/10.1074/jbc.m100925200
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9
Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27Kip1 in the cyclin E–cdk2 complexes
Autor: Colin K. W. Watts, Keren Hirsch, Yoav Sharoni, Michael Danilenko, Amit Nahum, Owen W. J. Prall, Joseph Levy
Publikováno v: Oncogene. 20:3428-3436
Numerous studies have demonstrated the anticancer activity of the tomato carotenoid, lycopene. However, the molecular mechanism of this action remains unknown. Lycopene inhibition of human breast and endometrial cancer cell growth is associated with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a80980d50a716783609d918a3e5f363
https://doi.org/10.1038/sj.onc.1204452
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10
A Pure Estrogen Antagonist Inhibits Cyclin E-Cdk2 Activity in MCF-7 Breast Cancer Cells and Induces Accumulation of p130-E2F4 Complexes Characteristic of Quiescence
Autor: Elizabeth A. Musgrove, Robert L. Sutherland, Owen W. J. Prall, Jason S. Carroll
Publikováno v: Journal of Biological Chemistry. 275:38221-38229
Estrogen antagonists inhibit cell cycle progression in estrogen-responsive cells, but the molecular mechanisms are not fully defined. Antiestrogen-mediated G(0)/G(1) arrest is associated with decreased cyclin D1 gene expression, inactivation of cycli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f75e5acd3325bbd025d7dea2df8c54
https://doi.org/10.1074/jbc.m004424200
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