Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Owen SC"'
Autor:
Nancy Aguilera, Tao Liu, Andrew J. Bower, Joanne Li, Sarah Abouassali, Rongwen Lu, John Giannini, Maximilian Pfau, Chelsea Bender, Margery G. Smelkinson, Amelia Naik, Bin Guan, Owen Schwartz, Andrei Volkov, Alfredo Dubra, Zhuolin Liu, Daniel X. Hammer, Dragan Maric, Robert Fariss, Robert B. Hufnagel, Brett G. Jeffrey, Brian P. Brooks, Wadih M. Zein, Laryssa A. Huryn, Johnny Tam
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
The in vivo pathogenesis of the blinding retinal degeneration choroideremia is visualized, which reveals enlarged and area-disrupted retinal pigment epithelial cells, providing evidence for polymegathism in choroideremia.
Externí odkaz:
https://doaj.org/article/23f1aa92e6bc467cb2c2e52b88e2d152
Autor:
Diogo Garcia Valadares, Owen Scott Clay, Yani Chen, Breanna Mary Scorza, Suzanne Louise Cassel, Fayyaz Shiraz Sutterwala, Mary Edythe Wilson
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106163- (2023)
Summary: The NLR protein NLRP12 contributes to innate immunity, but the mechanism remains elusive. Infection of Nlrp12−/− or wild-type mice with Leishmania infantum led to aberrant parasite tropism. Parasites replicated to higher levels in livers
Externí odkaz:
https://doaj.org/article/e56eaefbcff3423da0f4c07acf10fb14
Autor:
Shoichet, Brian, Owen, SC, Doak, AK, Ganesh, AN, Nedyalkova, L, McLaughlin, CK, Shoichet, BK, Shoichet, MS
Publikováno v:
Shoichet, Brian; Owen, SC; Doak, AK; Ganesh, AN; Nedyalkova, L; McLaughlin, CK; et al.(2014). Colloidal drug formulations can explain "bell-shaped" concentration-response curves. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/8g1474cn
Drug efficacy does not always increase sigmoidally with concentration, which has puzzled the community for decades. Unlike standard sigmoidal curves, bell-shaped concentration-response curves suggest more complex biological effects, such as multiple-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::07b00bce0752cbe1de7dc40fcf5b459d
http://www.escholarship.org/uc/item/8g1474cn
http://www.escholarship.org/uc/item/8g1474cn
Publikováno v:
Shoichet, Brian; Owen, SC; Doak, AK; Wassam, P; Shoichet, MS; & Shoichet, BK. (2012). Colloidal aggregation affects the efficacy of anticancer drugs in cell culture. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/5vz3v12t
Many small molecules, including bioactive molecules and approved drugs, spontaneously form colloidal aggregates in aqueous solution at micromolar concentrations. Though it is widely accepted that aggregation leads to artifacts in screens for ligands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::ce32752a0df1b185ab0de9e18a26e0d9
http://www.escholarship.org/uc/item/5vz3v12t
http://www.escholarship.org/uc/item/5vz3v12t
Akademický článek
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Autor:
Major M; Department of Molecular Pharmaceutics, College of Pharmacy, University of Utah, 30 South 2000 East, Salt Lake City, UT 84112, USA., Nervig CS; Department of Medicinal Chemistry, College of Pharmacy, University of Utah, 30 South 2000 East, Salt Lake City, UT 84112, USA., Gerland A; Department of Molecular Pharmaceutics, College of Pharmacy, University of Utah, 30 South 2000 East, Salt Lake City, UT 84112, USA., Owen SC; Department of Molecular Pharmaceutics, College of Pharmacy, University of Utah, 30 South 2000 East, Salt Lake City, UT 84112, USA.; Department of Medicinal Chemistry, College of Pharmacy, University of Utah, 30 South 2000 East, Salt Lake City, UT 84112, USA.; Department of Biomedical Engineering, College of Engineering, University of Utah, 36 S. Wasatch Drive, SMBB 3100, Salt Lake City, UT 84112, USA.
Publikováno v:
Pharmaceutics [Pharmaceutics] 2024 Jun 02; Vol. 16 (6). Date of Electronic Publication: 2024 Jun 02.
Autor:
Nguyen J; Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of Pharmacy, UNC, Chapel Hill, NC 27599, United States; Department of Biomedical Engineering, NC State/UNC, Chapel Hill, NC 27695, United States. Electronic address: julianen@email.unc.edu., Owen SC; Department of Molecular Pharmaceutics; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA. Electronic address: shawn.owen@hsc.utah.edu.
Publikováno v:
Advanced drug delivery reviews [Adv Drug Deliv Rev] 2024 May; Vol. 208, pp. 115273. Date of Electronic Publication: 2024 Mar 05.
Autor:
Owen SC; Department of Molecular Pharmaceutics, Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, the United States of America. Electronic address: shawn.owen@hsc.utah.edu., Nguyen J; Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of Pharmacy, UNC, Chapel Hill, NC 27599, the United States of America; Department of Biomedical Engineering, NC State/UNC, Chapel Hill, NC 27695, the United States of America. Electronic address: julianen@email.unc.edu.
Publikováno v:
Advanced drug delivery reviews [Adv Drug Deliv Rev] 2024 May; Vol. 208, pp. 115293. Date of Electronic Publication: 2024 Mar 21.
Autor:
Braun S; The Department of Rehabilitation Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA., Bastian L; The Department of Rehabilitation Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA., Hayes C; The Department of Rehabilitation Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA., Owen SC; Department of Neurology, Brooke Army Medical Center, San Antonio, TX 78234, USA., Craig C; Department of Neurology, Brooke Army Medical Center, San Antonio, TX 78234, USA., Nelson A; Department of Neurology, Brooke Army Medical Center, San Antonio, TX 78234, USA.
Publikováno v:
Military medicine [Mil Med] 2024 Feb 27; Vol. 189 (3-4), pp. e915-e918.
Autor:
Nervig CS; Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT, USA., Gustat JR; Department of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT, USA., Owen SC; Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT, USA. shawn.owen@hsc.utah.edu.; Department of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT, USA. shawn.owen@hsc.utah.edu.; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA. shawn.owen@hsc.utah.edu.
Publikováno v:
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2024; Vol. 2720, pp. 75-84.