Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Owen R. Dando"'
Autor:
Antonis Asiminas, Sam A. Booker, Owen R. Dando, Zrinko Kozic, Daisy Arkell, Felicity H. Inkpen, Anna Sumera, Irem Akyel, Peter C. Kind, Emma R. Wood
Publikováno v:
Molecular Autism, Vol 13, Iss 1, Pp 1-29 (2022)
Abstract Background Fragile X syndrome (FXS) is a common single gene cause of intellectual disability and autism spectrum disorder. Cognitive inflexibility is one of the hallmarks of FXS with affected individuals showing extreme difficulty adapting t
Externí odkaz:
https://doaj.org/article/e0dabc1eced84dd8ab6b7b80f7f03aae
Autor:
Natasha J. Anstey, Vijayakumar Kapgal, Shashank Tiwari, Thomas C. Watson, Anna K. H. Toft, Owen R. Dando, Felicity H. Inkpen, Paul S. Baxter, Zrinko Kozić, Adam D. Jackson, Xin He, Mohammad Sarfaraz Nawaz, Aiman Kayenaat, Aditi Bhattacharya, David J. A. Wyllie, Sumantra Chattarji, Emma R. Wood, Oliver Hardt, Peter C. Kind
Publikováno v:
Molecular Autism, Vol 13, Iss 1, Pp 1-19 (2022)
Abstract Background Mutations in the postsynaptic transmembrane protein neuroligin-3 are highly correlative with autism spectrum disorders (ASDs) and intellectual disabilities (IDs). Fear learning is well studied in models of these disorders, however
Externí odkaz:
https://doaj.org/article/3d9e90cbc8e047a6a47ce223c07a8fd8
Autor:
Sam A. Booker, Aleksander P. F. Domanski, Owen R. Dando, Adam D. Jackson, John T. R. Isaac, Giles E. Hardingham, David J. A. Wyllie, Peter C. Kind
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Fragile X syndrome and autism spectrum disorders are associated with circuit hyperexcitability, however, its cellular and synaptic bases are not well understood. Here, the authors report abnormal synaptogenesis with an increased prevalence of polysyn
Externí odkaz:
https://doaj.org/article/2fbc40b23b8f4722ab1014116cebc102
Autor:
Sam A. Booker, Laura Simões de Oliveira, Natasha J. Anstey, Zrinko Kozic, Owen R. Dando, Adam D. Jackson, Paul S. Baxter, Lori L. Isom, Diane L. Sherman, Giles E. Hardingham, Peter J. Brophy, David J.A. Wyllie, Peter C. Kind
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 107988- (2020)
Summary: Cellular hyperexcitability is a salient feature of fragile X syndrome animal models. The cellular basis of hyperexcitability and how it responds to changing activity states is not fully understood. Here, we show increased axon initial segmen
Externí odkaz:
https://doaj.org/article/43e9885c0bb64e499d98b5c2d2ae7c83
Autor:
Michael JD Daniels, Lucas Lefevre, Stefan Szymkowiak, Alice Drake, Laura McCulloch, Makis Tzioras, Jack Barrington, Owen R Dando, Xin He, Mehreen Mohammad, Hiroki Sasaguri, Takashi Saito, Takaomi C Saido, Tara L Spires-Jones, Barry W McColl
Publikováno v:
eLife, Vol 12 (2023)
Microglial endolysosomal (dys)function is strongly implicated in neurodegenerative disease. Transcriptomic studies show that a microglial state characterised by a set of genes involved in endolysosomal function is induced in both mouse Alzheimer’s
Externí odkaz:
https://doaj.org/article/b34f7f5ec669424295c17df5e3b3199f
Autor:
Olivia M. Rifai, Judi O’Shaughnessy, Owen R. Dando, Alison F. Munro, Michael D.E. Sewell, Sharon Abrahams, Fergal M. Waldron, Christopher R. Sibley, Jenna M. Gregory
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by progressive loss of upper and lower motor neurons. ALS is on a pathogenetic disease spectrum with frontotemporal dementia (FTD), with patients sometimes experiencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30a6117d07ef89750449883a80f227b2
https://doi.org/10.1101/2023.01.19.524561
https://doi.org/10.1101/2023.01.19.524561
Autor:
Michael J. D. Daniels, Lucas Lefevre, Stefan Szymkowiak, Alice Drake, Laura McCulloch, Makis Tzioras, Jack Barrington, Owen R. Dando, Xin He, Mehreen Mohammad, Hiroki Sasaguri, Takashi Saito, Takaomi C. Saido, Tara L. Spires-Jones, Barry W. McColl
Microglial endolysosomal (dys)function is strongly implicated in neurodegeneration. Transcriptomic studies show that a microglial state characterised by a set of genes involved in endolysosomal function is induced in both mouse Alzheimer’s Disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7368a7f1644cccc30e5bda42b58db105
https://doi.org/10.1101/2022.11.18.516922
https://doi.org/10.1101/2022.11.18.516922
Autor:
Natasha J. Anstey, Vijayakumar Kapgal, Shashank Tiwari, Thomas C. Watson, Anna K. H. Toft, Owen R. Dando, Felicity H. Inkpen, Paul S. Baxter, Zrinko Kozić, Adam D. Jackson, Xin He, Mohammad Sarfaraz Nawaz, Aiman Kayenaat, Aditi Bhattacharya, David J. A. Wyllie, Sumantra Chattarji, Emma R. Wood, Oliver Hardt, Peter C. Kind
Publikováno v:
Anstey, N J, Kapgal, V, Tiwari, S, Watson, T C, Toft, A K H, Dando, O R, Inkpen, F H, Baxter, P S, Kozic, Z, Jackson, A D, He, X, Nawaz, M S, Kayenaat, A, Bhattacharya, A, Wyllie, D J A, Chattarji, S, Wood, E R, Hardt, O & Kind, P C 2022, ' Imbalance of flight-freeze responses and their cellular correlates in the Nlgn3-/y rat model of autism ', Molecular Autism, vol. 13, 34 . https://doi.org/10.1186/s13229-022-00511-8
BackgroundMutations in the postsynaptic transmembrane protein neuroligin-3 are highly correlative with autism spectrum disorders (ASDs) and intellectual disabilities (IDs). Fear learning is well studied in models of these disorders, however differenc
Autor:
Makis Tzioras, Michael Daniels, Caitlin Davies, Monique Hooley, Xin He, Owen R. Dando, Giles Hardingham, Barry McColl, Tara L. Spires‐Jones
Publikováno v:
Alzheimer's & Dementia. 17
Autor:
Natasha J, Anstey, Vijayakumar, Kapgal, Shashank, Tiwari, Thomas C, Watson, Anna K H, Toft, Owen R, Dando, Felicity H, Inkpen, Paul S, Baxter, Zrinko, Kozić, Adam D, Jackson, Xin, He, Mohammad Sarfaraz, Nawaz, Aiman, Kayenaat, Aditi, Bhattacharya, David J A, Wyllie, Sumantra, Chattarji, Emma R, Wood, Oliver, Hardt, Peter C, Kind
Publikováno v:
Molecular autism. 13(1)
Mutations in the postsynaptic transmembrane protein neuroligin-3 are highly correlative with autism spectrum disorders (ASDs) and intellectual disabilities (IDs). Fear learning is well studied in models of these disorders, however differences in fear