Zobrazeno 1 - 10
of 485
pro vyhledávání: '"Owen N. Witte"'
Autor:
Lisa Ta, Brandon L. Tsai, Weixian Deng, Jihui Sha, Grigor Varuzhanyan, Wendy Tran, James A. Wohlschlegel, Janai R. Carr-Ascher, Owen N. Witte
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108480- (2023)
Summary: Mutated Ras and Raf kinases are well-known to promote cancer metastasis via flux through the Ras/Raf/MEK/ERK (mitogen-activated protein kinase [MAPK]) pathway. A role for non-mutated Raf in metastasis is also emerging, but the key mechanisms
Externí odkaz:
https://doaj.org/article/50c08eec40e64d8eaf3c2bad01473b66
Autor:
Songming Peng, Jesse M. Zaretsky, Alphonsus H.C. Ng, William Chour, Michael T. Bethune, Jongchan Choi, Alice Hsu, Elizabeth Holman, Xiaozhe Ding, Katherine Guo, Jungwoo Kim, Alexander M. Xu, John E. Heath, Won Jun Noh, Jing Zhou, Yapeng Su, Yue Lu, Jami McLaughlin, Donghui Cheng, Owen N. Witte, David Baltimore, Antoni Ribas, James R. Heath
Publikováno v:
Cell Reports, Vol 28, Iss 10, Pp 2728-2738.e7 (2019)
Summary: Neoantigen-specific T cells are increasingly viewed as important immunotherapy effectors, but physically isolating these rare cell populations is challenging. Here, we describe a sensitive method for the enumeration and isolation of neoantig
Externí odkaz:
https://doaj.org/article/43a6df712a824f30a578af81377be174
Autor:
Bryan A. Smith, Nikolas G. Balanis, Avinash Nanjundiah, Katherine M. Sheu, Brandon L. Tsai, Qingfu Zhang, Jung Wook Park, Michael Thompson, Jiaoti Huang, Owen N. Witte, Thomas G. Graeber
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3353-3366.e5 (2018)
Summary: Cancer progression to an aggressive phenotype often co-opts aspects of stem cell biology. Here, we developed gene signatures for normal human stem cell populations to understand the relationship between epithelial cancers and stem cell trans
Externí odkaz:
https://doaj.org/article/941c3d3a58854d218e6a21f2ae06cbc8
Autor:
Bao Ying Chen, Jessica R. Salas, Alyssa O. Trias, Arely Perez Rodriguez, Jonathan E. Tsang, Miriam Guemes, Thuc M. Le, Zoran Galic, H. Michael Shepard, Lawrence Steinman, David A. Nathanson, Johannes Czernin, Owen N. Witte, Caius G. Radu, Kenneth A. Schultz, Peter M. Clark
Publikováno v:
Immunology. 168:152-169
Multiple sclerosis (MS) is an autoimmune disease driven by lymphocyte activation against myelin autoantigens in the central nervous system leading to demyelination and neurodegeneration. The deoxyribonucleoside salvage pathway with the rate-limiting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc2389100509e821a331ad70ab321fa
https://doi.org/10.1111/imm.13569
https://doi.org/10.1111/imm.13569
Autor:
Yang Pan, John W. Phillips, Beatrice D. Zhang, Miyako Noguchi, Eric Kutschera, Jami McLaughlin, Pavlo A. Nesterenko, Zhiyuan Mao, Nathanael J. Bangayan, Robert Wang, Wendy Tran, Harry T. Yang, Yuanyuan Wang, Yang Xu, Matthew B. Obusan, Donghui Cheng, Alex H. Lee, Kathryn E. Kadash-Edmondson, Ameya Champhekar, Cristina Puig-Saus, Antoni Ribas, Robert M. Prins, Christopher S. Seet, Gay M. Crooks, Owen N. Witte, Yi Xing
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 120, iss 21
Alternative splicing (AS) is prevalent in cancer, generating an extensive but largely unexplored repertoire of novel immunotherapy targets. We describe I soform peptides from R NA splicing for I mmunotherapy target S creening (IRIS), a computational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93609197fd5c544787a244456cbfc71
https://doi.org/10.1073/pnas.2221116120
https://doi.org/10.1073/pnas.2221116120
XLSX file - 12K, Quantification of phenotypes observed in human samples across four histological sections from independent biological replicates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42843497e935437370d74f5c399ed65
https://doi.org/10.1158/1541-7786.22509327.v1
https://doi.org/10.1158/1541-7786.22509327.v1
PDF file - 1490K, Autocrine expression of OSM with activation of AKT promotes invasive epithelial growth from benign lesions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bb057df56019795e8fe09ef2114b7f
https://doi.org/10.1158/1541-7786.22509345.v1
https://doi.org/10.1158/1541-7786.22509345.v1
Autor:
Heather R. Christofk, Hong Wu, William D. Tap, Owen N. Witte, Fritz C. Eilber, Kathleen B. Smith, Matthias R. Benz, Mirielle Riedinger, David Nathanson, Brenna Tam, Ethan Ahler, Daniel Braas
PDF file - 163K, Supplemental Figure 1: Serially passaged liposarcoma xenograft tumors derived from primary tumors and xenograft tumors derived from liposarcoma cell lines both exhibit similar 18F-FDG uptake by PET. Supplemental Figure 2: High grade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c237ee7c3b296cba6ac3d9c1c88802
https://doi.org/10.1158/2159-8290.22529046
https://doi.org/10.1158/2159-8290.22529046
Autor:
Heather R. Christofk, Hong Wu, William D. Tap, Owen N. Witte, Fritz C. Eilber, Kathleen B. Smith, Matthias R. Benz, Mirielle Riedinger, David Nathanson, Brenna Tam, Ethan Ahler, Daniel Braas
PDF file - 85K, Gemcitabine has a cytotoxic effect on three liposarcoma cell lines. Supplemental Figure 7: Gemcitabine is cytotoxic to liposarcoma cell lines and xenograft tumors in mice. Supplemental Figure 8: Gemcitabine decreases tumor growth in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba1823d7a40006ffc57b388ba7cec81
https://doi.org/10.1158/2159-8290.22529037
https://doi.org/10.1158/2159-8290.22529037
Autor:
James R. Heath, Antoni Ribas, Begonya Comin-Anduix, James S. Economou, Bartosz Chmielowski, David Baltimore, Owen N. Witte, Alistair J. Cochran, Earl Avramis, Charles Ng, Zhongqi Wu, Richard C. Koya, Thinle Chodon, Ann F. Cheung, Chao Ma
PDF file - 1292K, Study scheme, assay validation, functional changes of patients F5-2 and F5-8.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c88c6ea6e08bff6b02ca1f29de0080d
https://doi.org/10.1158/2159-8290.22529706
https://doi.org/10.1158/2159-8290.22529706