Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Owen N. Vickery"'
Autor:
Rie Nygaard, Chris L. B. Graham, Meagan Belcher Dufrisne, Jonathan D. Colburn, Joseph Pepe, Molly A. Hydorn, Silvia Corradi, Chelsea M. Brown, Khuram U. Ashraf, Owen N. Vickery, Nicholas S. Briggs, John J. Deering, Brian Kloss, Bruno Botta, Oliver B. Clarke, Linda Columbus, Jonathan Dworkin, Phillip J. Stansfeld, David I. Roper, Filippo Mancia
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Peptidoglycan (PG) is an essential structural component of the bacterial cell wall that is synthetized during cell division and elongation. PG forms an extracellular polymer crucial for cellular viability, the synthesis of which is the targe
Externí odkaz:
https://doaj.org/article/f8db36713a734cacbd61374a4c829bb4
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Widespread antibiotic resistance, especially of Gram-negative bacteria, has become a severe concern for human health. Tripartite efflux pumps are one of the major contributors to resistance in Gram-negative pathogens, by efficiently expellin
Externí odkaz:
https://doaj.org/article/14bb12e59497474ea99ab84771bb053c
Autor:
Tracy A. Caldwell, Owen N. Vickery, Jonathan D. Colburn, Phillip J. Stansfeld, Linda Columbus
Publikováno v:
Biophys J
Lipoprotein signal peptidase (LspA) is an aspartyl protease that cleaves the transmembrane helix signal peptide of lipoproteins as part of the lipoprotein-processing pathway. Members of this pathway are excellent targets for the development of antibi
Autor:
Phillip J. Stansfeld, Jonathan D. Colburn, Owen N. Vickery, Rie Nygaard, Khuram U. Ashraf, Meagan L. Belcher Dufrisne, Jonathan Dworkin, Linda M. Columbus, Stephen Trent, David I. Roper, Filippo Mancia
Publikováno v:
Biophysical Journal. 122:300a
Autor:
Khuram U. Ashraf, Rie Nygaard, Owen N. Vickery, Satchal K. Erramilli, Carmen M. Herrera, Thomas H. McConville, Vasileios I. Petrou, Sabrina I. Giacometti, Meagan Belcher Dufrisne, Kamil Nosol, Allen P. Zinkle, Chris L. B. Graham, Michael Loukeris, Brian Kloss, Karolina Skorupinska-Tudek, Ewa Swiezewska, David I. Roper, Oliver B. Clarke, Anne-Catrin Uhlemann, Anthony A. Kossiakoff, M. Stephen Trent, Phillip J. Stansfeld, Filippo Mancia
Publikováno v:
Nature
The outer membrane of Gram-negative bacteria has an external leaflet that is largely composed of lipopolysaccharide, which provides a selective permeation barrier, particularly against antimicrobials1. The final and crucial step in the biosynthesis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423ffae297550f841ce5cdb98dd07627
http://wrap.warwick.ac.uk/163073/1/WRAP-Structural-Lipopolysaccharide-maturation-O-antigen-ligase-2022.pdf
http://wrap.warwick.ac.uk/163073/1/WRAP-Structural-Lipopolysaccharide-maturation-O-antigen-ligase-2022.pdf
Autor:
Owen N. Vickery, Phillip J. Stansfeld
Publikováno v:
Journal of Chemical Theory and Computation
Coarse-grained molecular dynamics provides a means for simulating the assembly and interactions of macromolecular complexes at a reduced level of representation, thereby allowing both longer timescale and larger sized simulations. Here, we describe a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ffdf5336a4435ad16826ea16b210b04
http://wrap.warwick.ac.uk/158078/1/WRAP-CG2AT2-enhanced-fragment-based-approach-serial-multi-scale-molecular-dynamics-simulations-Stansfeld-2021.pdf
http://wrap.warwick.ac.uk/158078/1/WRAP-CG2AT2-enhanced-fragment-based-approach-serial-multi-scale-molecular-dynamics-simulations-Stansfeld-2021.pdf
G-protein-coupled receptors (GPCRs) are membrane proteins that transmit signals across the cell membrane by activating intracellular effector proteins in response to extracellular ligand interaction. A large majority of GPCRs are characterized by an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52b1a91db44f4841ec30e9b46f794e13
https://doi.org/10.1101/2020.08.28.271510
https://doi.org/10.1101/2020.08.28.271510
Autor:
Justin C. Deme, Holly Monkhouse, Samuel Johnson, A Muellbauer, R Hennell James, James W. Coulton, Owen N. Vickery, Ben C. Berks, Phillip J. Stansfeld, Susan M. Lea, Thomas Griffiths
Publikováno v:
Nature microbiology
SummaryThe bacterial flagellum is the proto-typical protein nanomachine and comprises a rotating helical propeller attached to a membrane-embedded motor complex1. The motor consists of a central rotor surround by stator units that couple ion flow acr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353a12a1b6e1d8968fe7bc8d08121e20
Autor:
David A. Köpfer, Wojciech Kopec, Thomas L. C. Jansen, Owen N. Vickery, Ulrich Zachariae, Bert L. de Groot, Anna S. Bondarenko
Publikováno v:
Nature Chemistry, 10(8), 813-820. Nature Publishing Group
Nature Chemistry
Nature Chemistry
The seeming contradiction that K+ channels conduct K+ ions at maximal throughput rates while not permeating slightly smaller Na+ ions has perplexed scientists for decades. Although numerous models have addressed selective permeation in K+ channels, t
Publikováno v:
Biophysical Journal. 120:49a