Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Owen Kantelberg"'
Autor:
Samuel B Pattle, Judi O'Shaughnessy, Owen Kantelberg, Olivia M Rifai, Judith Pate, Kristine Nellany, Nadine Hays, Mark J Arends, Mathew H Horrocks, Fergal M Waldron, Jenna M Gregory
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 1, Pp 44-55 (2023)
Abstract Neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS) are traditionally considered strictly neurological disorders. However, clinical presentation is not restricted to
Externí odkaz:
https://doaj.org/article/c5efc50753334660a96f553350f6b2fe
Autor:
Matthew J. Broadhead, Ani Ayvazian-Hancock, Katherine Doucet, Owen Kantelberg, Lesley Motherwell, Fei Zhu, Seth G. N. Grant, Mathew H. Horrocks, Gareth B. Miles
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Amyotrophic Lateral Sclerosis (ALS) is characterised by a loss of motor neurons in the brain and spinal cord that is preceded by early-stage changes in synapses that may be associated with TAR-DNA-Binding Protein 43 (TDP-43) pathology. Cellular inclu
Externí odkaz:
https://doaj.org/article/e5081c3854aa45ba9122fdc83da492db
Autor:
Elsa Zacco, Owen Kantelberg, Edoardo Milanetti, Alexandros Armaos, Francesco Paolo Panei, Jenna Gregory, Kiani Jeacock, David J. Clarke, Siddharthan Chandran, Giancarlo Ruocco, Stefano Gustincich, Mathew H. Horrocks, Annalisa Pastore, Gian Gaetano Tartaglia
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Here, the authors generated an artificial RNA molecule, or aptamer, specific for the Amyotrophic Lateral Sclerosis protein TDP-43. By interacting avidly with its target, the aptamer can be exploited to track TDP-43 phase transition in vitro and in ce
Externí odkaz:
https://doaj.org/article/313504fc94a146ba963e22a3b9d3a822
Autor:
Alexandre Chappard, Craig Leighton, Rebecca S. Saleeb, Kiani Jeacock, Sarah R. Ball, Katie Morris, Owen Kantelberg, Ji‐Eun Lee, Elsa Zacco, Annalisa Pastore, Margaret Sunde, David J. Clarke, Patrick Downey, Tilo Kunath, Mathew H. Horrocks
Publikováno v:
Chappard, A, Leighton, C, Saleeb, R S, Jeacock, K, Ball, S, Morris, K, Kantelberg, O, Lee, J E, Zacco, E, Pastore, A, Sunde, M, Clarke, D J, Downey, P, Kunath, T & Horrocks, M H 2023, ' Single-Molecule Two-Color Coincidence Detection of Unlabeled alpha-Synuclein Aggregates ', Angewandte Chemie-International Edition, vol. 62, no. 15, e202216771 . https://doi.org/10.1002/anie.202216771
Protein misfolding and aggregation into oligomeric and fibrillar structures is a common feature of many neurogenerative disorders. Single-molecule techniques have enabled characterization of these lowly abundant, highly heterogeneous protein aggregat
Autor:
Samuel B Pattle, Judi O'Shaughnessy, Owen Kantelberg, Olivia M Rifai, Judith Pate, Kristine Nellany, Nadine Hays, Mark J Arends, Mathew H Horrocks, Fergal M Waldron, Jenna M Gregory
Publikováno v:
Pattle, S B, O'shaughnessy, J, Kantelberg, O, Rifai, O, Pate, J, Nellany, K, Hays, N, Arends, M J, Horrocks, M H, Waldron, F & Gregory, J M 2023, ' pTDP-43 aggregates accumulate in non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis; a case series linking archival surgical biopsies with clinical phenotypic data ', Journal of Pathology, vol. 9, no. 1, pp. 44-55 . https://doi.org/10.1002/cjp2.297
Neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS) are traditionally considered strictly neurological disorders. However, clinical presentation is not restricted to neurologi
Autor:
Matthew J. Broadhead, Katherine Doucet, Owen Kantelberg, Fei Zhu, Seth GN Grant, Mathew H Horrocks, Gareth B. Miles
Cellular inclusions of hyperphosphorylated TAR-DNA-Binding Protein 43 (TDP-43) are a key hallmark of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS). ALS is characterised by a loss of motor neurons in the brain and spinal cord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d53311991e52eb2125557f7906c8e1d4
https://doi.org/10.1101/2022.08.29.505610
https://doi.org/10.1101/2022.08.29.505610
Autor:
Elsa Zacco, Owen Kantelberg, Edoardo Milanetti, Alexandros Armaos, Francesco Paolo Panei, Jenna Gregory, Kiani Jeacock, David J. Clarke, Siddharthan Chandran, Giancarlo Ruocco, Stefano Gustincich, Mathew H. Horrocks, Annalisa Pastore, Gian Gaetano Tartaglia
Publikováno v:
Zacco, E, Kantelberg, O, Milanetti, E, Armaos, A, Panei, F P, Gregory, J, Jeacock, K, Clarke, D J, Chandran, S, Ruocco, G, Gustincich, S, Horrocks, M H, Pastore, A & Tartaglia, G G 2022, ' Probing TDP-43 condensation using an in silico designed aptamer ', Nature Communications, vol. 13, no. 1, pp. 3306 . https://doi.org/10.1038/s41467-022-30944-x
Aptamers are artificial oligonucleotides binding to specific molecular targets. They have a promising role in therapeutics and diagnostics but are often difficult to design. Here, we exploited the catRAPID algorithm to generate aptamers targeting TAR
Autor:
Simon G. J. Mochrie, Mathew H. Horrocks, Louise Holyoake, Lynne Regan, Owen Kantelberg, Curran Oi, Zoe Gidden
Super-resolution imaging of proteins inside live cells is a powerful tool for investigating protein behavior. We have developed a super-resolution method we call LIVE-PAINT, which uses reversible peptide-protein interactions to achieve super-resoluti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0175c137d97ebb3fbd1f56b7c8dd2b82
https://doi.org/10.21203/rs.3.pex-1043/v1
https://doi.org/10.21203/rs.3.pex-1043/v1
Autor:
Simon G. J. Mochrie, Louise Holyoake, Lynne Regan, Owen Kantelberg, Zoe Gidden, Curran Oi, Mathew H. Horrocks
Publikováno v:
Communications Biology
Oi, C, Gidden, Z, Holyoake, L, Kantelberg, O, Mochrie, S, Horrocks, M H & Regan, L 2020, ' LIVE-PAINT : Allows super-resolution microscopy inside living cells using reversible peptide-protein interactions ', Communications biology, vol. 3, no. 1, 458 . https://doi.org/10.1038/s42003-020-01188-6
Communications Biology, Vol 3, Iss 1, Pp 1-10 (2020)
Oi, C, Gidden, Z, Holyoake, L, Kantelberg, O, Mochrie, S, Horrocks, M H & Regan, L 2020, ' LIVE-PAINT : Allows super-resolution microscopy inside living cells using reversible peptide-protein interactions ', Communications biology, vol. 3, no. 1, 458 . https://doi.org/10.1038/s42003-020-01188-6
Communications Biology, Vol 3, Iss 1, Pp 1-10 (2020)
We present LIVE-PAINT, a new approach to super-resolution fluorescent imaging inside live cells. In LIVE-PAINT only a short peptide sequence is fused to the protein being studied, unlike conventional super-resolution methods, which rely on directly f
Autor:
Simon G. J. Mochrie, Louise Holyoake, Owen Kantelberg, Curran Oi, Mathew H. Horrocks, Lynne Regan, Zoe Gidden
We present LIVE-PAINT, a new approach to super-resolution fluorescent imaging inside live cells. In LIVE-PAINT only a short peptide sequence is fused to the protein being studied, unlike conventional super-resolution methods, which rely on directly f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb60f13b87a5e200b23cfd179ebbebce