Zobrazeno 1 - 10
of 676
pro vyhledávání: '"Owen J. Sansom"'
Autor:
Johanna Lilja, Jasmin Kaivola, James R. W. Conway, Joni Vuorio, Hanna Parkkola, Pekka Roivas, Michal Dibus, Megan R. Chastney, Taru Varila, Guillaume Jacquemet, Emilia Peuhu, Emily Wang, Ulla Pentikäinen, Itziar Martinez D. Posada, Hellyeh Hamidi, Arafath K. Najumudeen, Owen J. Sansom, Igor L. Barsukov, Daniel Abankwa, Ilpo Vattulainen, Marko Salmi, Johanna Ivaska
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The KRAS oncogene drives many common and highly fatal malignancies. These include pancreatic, lung, and colorectal cancer, where various activating KRAS mutations have made the development of KRAS inhibitors difficult. Here we identify the s
Externí odkaz:
https://doaj.org/article/aab4a06c715b4e4481e20d3e6037ab7e
Autor:
Kathryn A. F. Pennel, Phimmada Hatthakarnkul, Colin S. Wood, Guang-Yu Lian, Sara S. F. Al-Badran, Jean A. Quinn, Assya Legrini, Jitwadee Inthagard, Peter G. Alexander, Hester van Wyk, Ahmad Kurniawan, Umar Hashmi, Michael A. Gillespie, Megan Mills, Aula Ammar, Jennifer Hay, Ditte Andersen, Colin Nixon, Selma Rebus, David K. Chang, Caroline Kelly, Andrea Harkin, Janet Graham, David Church, Ian Tomlinson, Mark Saunders, Tim Iveson, Tamsin R. M. Lannagan, Rene Jackstadt, Noori Maka, Paul G. Horgan, Campbell S. D. Roxburgh, Owen J. Sansom, Donald C. McMillan, Colin W. Steele, Nigel B. Jamieson, James H. Park, Antonia K. Roseweir, Joanne Edwards
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-20 (2024)
Abstract Colorectal cancer (CRC) is a heterogenous malignancy underpinned by dysregulation of cellular signaling pathways. Previous literature has implicated aberrant JAK/STAT3 signal transduction in the development and progression of solid tumors. I
Externí odkaz:
https://doaj.org/article/3b63169b435447a19a5fb490ee037279
Autor:
Reshmi Nair, Tamsin R. M. Lannagan, Rene Jackstadt, Anna Andrusaite, John Cole, Caitlin Boyne, Robert J. B. Nibbs, Owen J. Sansom, Simon Milling
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTColorectal cancer (CRC) is the third most prevalent cancer worldwide with a high mortality rate (20–30%), especially due to metastasis to adjacent organs. Clinical responses to chemotherapy, radiation, targeted and immunotherapies are limit
Externí odkaz:
https://doaj.org/article/990e4b206f444c4f9e950f6acf44d5d0
Autor:
Arafath K. Najumudeen, Sigrid K. Fey, Laura M. Millett, Catriona A. Ford, Kathryn Gilroy, Nuray Gunduz, Rachel A. Ridgway, Eve Anderson, Douglas Strathdee, William Clark, Colin Nixon, Jennifer P. Morton, Andrew D. Campbell, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Oncogenic KRAS mutations are well-described functionally and are known to drive tumorigenesis. Recent reports describe a significant prevalence of KRAS allelic imbalances or gene dosage changes in human cancers, including loss of the wild-ty
Externí odkaz:
https://doaj.org/article/cc435f850ded4ca6b07a54a34129b55d
Autor:
Lydia Melissourgou-Syka, Michael A. Gillespie, Sean M. O'Cathail, Owen J. Sansom, Colin W. Steele, Campbell S. D. Roxburgh
Publikováno v:
Journal of Immunotherapy and Precision Oncology, Vol 6, Iss 4, Pp 187-197 (2023)
Colorectal cancer (CRC) is the third most common malignancy across the globe and, despite advances in treatment strategies, survival rates remain low. Rectal cancer (RC) accounts for most of these cases, and traditional management strategies for adva
Externí odkaz:
https://doaj.org/article/8489cce57d0f48d292b136f85aaed0f1
Autor:
Mathias Tesson, Katrina Stevenson, Saadia A. Karim, Colin Nixon, Anthony J. Chalmers, Owen J. Sansom, Eric O'Neill, Keaton Jones, Jennifer P. Morton
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/811eecd6813e422088dd8c4cda49dc78
Autor:
Amy K. Holt, Arafath K. Najumudeen, Tracey J. Collard, Hao Li, Laura M. Millett, Ashley J. Hoskin, Danny N. Legge, Eleanor M. H. Mortensson, Dustin J. Flanagan, Nicholas Jones, Madhu Kollareddy, Penny Timms, Matthew D. Hitchings, James Cronin, Owen J. Sansom, Ann C. Williams, Emma E. Vincent
Publikováno v:
Cancer & Metabolism, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract Background To support proliferation and survival within a challenging microenvironment, cancer cells must reprogramme their metabolism. As such, targeting cancer cell metabolism is a promising therapeutic avenue. However, identifying tractab
Externí odkaz:
https://doaj.org/article/d2b8ee6de35a474887a1c18cb634d284
Autor:
Peter Bailey, Rachel A. Ridgway, Patrizia Cammareri, Mairi Treanor-Taylor, Ulla-Maja Bailey, Christina Schoenherr, Max Bone, Daniel Schreyer, Karin Purdie, Jason Thomson, William Rickaby, Rene Jackstadt, Andrew D. Campbell, Emmanouil Dimonitsas, Alexander J. Stratigos, Sarah T. Arron, Jun Wang, Karen Blyth, Charlotte M. Proby, Catherine A. Harwood, Owen J. Sansom, Irene M. Leigh, Gareth J. Inman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract The molecular basis of disease progression from UV-induced precancerous actinic keratosis (AK) to malignant invasive cutaneous squamous cell carcinoma (cSCC) and potentially lethal metastatic disease remains unclear. DNA sequencing studies h
Externí odkaz:
https://doaj.org/article/12b4077a59444dd3949da320a9c0d1e9
Autor:
Dustin J. Flanagan, Raheleh Amirkhah, David F. Vincent, Nuray Gundaz, Pauline Gentaz, Patrizia Cammareri, Aoife J. McCooey, Amy M. B. McCorry, Natalie C. Fisher, Hayley L. Davis, Rachel A. Ridgway, Jeroen Lohuis, Joshua D. G. Leach, Rene Jackstadt, Kathryn Gilroy, Elisa Mariella, Colin Nixon, William Clark, Ann Hedley, Elke K. Markert, Douglas Strathdee, Laurent Bartholin, Keara L. Redmond, Emma M. Kerr, Daniel B. Longley, Fiona Ginty, Sanghee Cho, Helen G. Coleman, Maurice B. Loughrey, Alberto Bardelli, Timothy S. Maughan, Andrew D. Campbell, Mark Lawler, Simon J. Leedham, Simon T. Barry, Gareth J. Inman, Jacco van Rheenen, Philip D. Dunne, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
It remains critical to identify colorectal cancers (CRC) that will disseminate as early as possible. Here, the authors identify CRC tumours that are aggressive and prone to early dissemination, characterised by epithelial TGFβ and growth-factor sign
Externí odkaz:
https://doaj.org/article/685f337608c24440b7e084866104173a
Autor:
Eva C. Freckmann, Emma Sandilands, Erin Cumming, Matthew Neilson, Alvaro Román-Fernández, Konstantina Nikolatou, Marisa Nacke, Tamsin R. M. Lannagan, Ann Hedley, David Strachan, Mark Salji, Jennifer P. Morton, Lynn McGarry, Hing Y. Leung, Owen J. Sansom, Crispin J. Miller, David M. Bryant
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
There are currently a lack of tools to detect heterogeneity in 3D cultures. Here the authors report Traject3d as a framework to identify heterogeneous states in 3D culture and to understand how these give rise to distinct phenotypes using label-free
Externí odkaz:
https://doaj.org/article/d1ea5c3909d0472cb9c9c41a696d4ec5