Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Owen J McGinn"'
Autor:
Thomas D Southgate, Owen J McGinn, Fernanda V Castro, Andrzej J Rutkowski, Mariam Al-Muftah, Georgi Marinov, Graeme J Smethurst, David Shaw, Christopher M Ward, Crispin J Miller, Peter L Stern
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e9982 (2010)
5T4 oncofetal molecules are highly expressed during development and upregulated in cancer while showing only low levels in some adult tissues. Upregulation of 5T4 expression is a marker of loss of pluripotency in the early differentiation of embryoni
Externí odkaz:
https://doaj.org/article/241e25236e374b98aa8b044b9f332cd1
Autor:
Owen J. McGinn, Shekhar Krishnan, Jean-Pierre Bourquin, Puja Sapra, Clare Dempsey, Vaskar Saha, Peter L. Stern
Publikováno v:
Haematologica, Vol 102, Iss 6 (2017)
Outcome in childhood acute lymphoblastic leukemia is prognosticated from levels of minimal residual disease after remission induction therapy. Higher levels of minimal residual disease are associated with inferior results even with intensification of
Externí odkaz:
https://doaj.org/article/05442df028064fb18d510a7f4c280324
Autor:
Puja Sapra, Shekhar Krishnan, Clare Dempsey, Vaskar Saha, Jean-Pierre Bourquin, Owen J McGinn, Peter L. Stern
Publikováno v:
Haematologica
McGinn, O J, Krishnan, S, Bourquin, J-P, Sapra, P, Dempsey, C, Saha, V & Stern, P L 2017, ' Targeting the 5T4 oncofetal glycoprotein with an antibody drug conjugate (A1mcMMAF) improves survival in patient-derived xenograft models of acute lymphoblastic leukemia ', Haematologica, vol. 102, no. 6, pp. 1075-1084 . https://doi.org/10.3324/haematol.2016.158485
McGinn, O J, Krishnan, S, Bourquin, J-P, Sapra, P, Dempsey, C, Saha, V & Stern, P L 2017, ' Targeting the 5T4 oncofetal glycoprotein with an antibody drug conjugate (A1mcMMAF) improves survival in patient-derived xenograft models of acute lymphoblastic leukemia ', Haematologica, vol. 102, no. 6, pp. 1075-1084 . https://doi.org/10.3324/haematol.2016.158485
Outcome in childhood acute lymphoblastic leukemia is prognosticated from levels of minimal residual disease after remission induction therapy. Higher levels of minimal residual disease are associated with inferior results even with intensification of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61fc1d8b8f5fc6a687592128b38c5bfb
https://pubmed.ncbi.nlm.nih.gov/28341731
https://pubmed.ncbi.nlm.nih.gov/28341731
Publikováno v:
Seminars in cancer biology. 29
Oncofoetal antigens are present during foetal development with generally limited expression in the adult but are upregulated in cancer. These molecules can sometimes be used to diagnose or follow treatment of tumours or as a target for different immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721ede16bff14bb8b75c61a11445bc49
https://pubmed.ncbi.nlm.nih.gov/25066861
https://pubmed.ncbi.nlm.nih.gov/25066861
Myeloproliferative neoplasm with eosinophilia and T-lymphoblastic lymphoma with ETV6–LYN gene fusion
Autor:
Katrina M Wood, Owen J McGinn, Vaskar Saha, Mark Richard James Williams, Seema Alexander, Adrian Bloor, Nick Telford
Publikováno v:
Blood Cancer Journal
Telford, N, Alexander, S, McGinn, O J, Williams, M, Wood, KM, Bloor, A & Saha, V 2016, ' Myeloproliferative neoplasm with eosinophilia and T-lymphoblastic lymphoma with ETV6–LYN gene fusion ', Blood cancer journal . https://doi.org/10.1038/bcj.2016.11
Telford, N, Alexander, S, McGinn, O J, Williams, M, Wood, KM, Bloor, A & Saha, V 2016, ' Myeloproliferative neoplasm with eosinophilia and T-lymphoblastic lymphoma with ETV6–LYN gene fusion ', Blood cancer journal . https://doi.org/10.1038/bcj.2016.11
Myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal haematopoietic stem cell disorders characterised by proliferation and maturation of different myeloid cell lineages. Classical MPNs are largely characterised by somatic mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37386b6777044f97c99901edfc08df51
https://doi.org/10.1038/bcj.2016.11
https://doi.org/10.1038/bcj.2016.11
Publikováno v:
Journal of cell science. 125(Pt 22)
CXCL12 is a pleiotropic chemokine capable of eliciting multiple signal transduction cascades and functions, via interaction with either CXCR4 or CXCR7. Factors that determine CXCL12 receptor preference, intracellular signalling route and biological r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a1c9efd693d455addf8b4cf6ad3751
https://pubmed.ncbi.nlm.nih.gov/22956548
https://pubmed.ncbi.nlm.nih.gov/22956548
Autor:
Eyad Elkord, Vaskar Saha, Mark Holland, Andrzej J. Rutkowski, Aurelia Gallego, Rasilaben Vaghjiani, Georgi Marinov, Fernanda Castro, Jian Li, Debbie Burt, Shekhar Krishnan, Owen J McGinn, Peter L. Stern
Publikováno v:
Leukemia
Although the overall prognosis in childhood acute lymphoblastic leukemia (ALL) is good, outcome after relapse is poor. Recurrence is frequently characterized by the occurrence of disease at extramedullary sites, such as the central nervous system and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb2f9864d5132173ca1e2fa874a83fbf
https://pubmed.ncbi.nlm.nih.gov/22266911
https://pubmed.ncbi.nlm.nih.gov/22266911
Publikováno v:
Cell biology international. 35(10)
ADAMs (a disintegrin and metalloproteinase) are a family of type I transmembrane glycoproteins related to snake venom metalloproteases and disintegrins. They are regulatory proteins that modulate intercellular adhesion and the bioavailability of grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13052a0e7b345e8cfb480a8680e35397
https://pubmed.ncbi.nlm.nih.gov/21332445
https://pubmed.ncbi.nlm.nih.gov/21332445
Autor:
Graeme J. Smethurst, Mariam Al-Muftah, Crispin J. Miller, Thomas D. Southgate, Christopher M. Ward, Owen J McGinn, Peter L. Stern, David M Shaw, Fernanda Castro, Andrzej J. Rutkowski, Georgi Marinov
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 4, p e9982 (2010)
PLoS ONE, Vol 5, Iss 4, p e9982 (2010)
5T4 oncofetal molecules are highly expressed during development and upregulated in cancer while showing only low levels in some adult tissues. Upregulation of 5T4 expression is a marker of loss of pluripotency in the early differentiation of embryoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08fa602a5cf21d04240838a4f07786f4
https://doi.org/10.1371/journal.pone.0009982
https://doi.org/10.1371/journal.pone.0009982
Autor:
Stephanie Harrison, Marco Fiorillo, Federica Sotgia, Vaskar Saha, Mayur Parihar, Suzanne M. Johnson, Michael P. Lisanti, Jizhong Liu, Amy L. Chadwick, Owen J McGinn, Yujun Di, Clare Dempsey, Shekhar Krishnan
Publikováno v:
Europe PubMed Central
Johnson, S M, Dempsey, C, Chadwick, A, Harrison, S, Liu, J, Di, Y, McGinn, O J, Fiorillo, M, Sotgia, F, Lisanti, M P, Parihar, M, Krishnan, S & Saha, V 2016, ' Metabolic reprogramming of bone marrow stromal cells by leukemic extracellular vesicles in acute lymphoblastic leukemia ', Blood, vol. 128, no. 3 . https://doi.org/10.1182/blood-2015-12-688051, https://doi.org/10.1182/blood-2015-12-688051
Johnson, S M, Dempsey, C, Chadwick, A, Harrison, S, Liu, J, Di, Y, McGinn, O J, Fiorillo, M, Sotgia, F, Lisanti, M P, Parihar, M, Krishnan, S & Saha, V 2016, ' Metabolic reprogramming of bone marrow stromal cells by leukemic extracellular vesicles in acute lymphoblastic leukemia ', Blood, vol. 128, no. 3 . https://doi.org/10.1182/blood-2015-12-688051, https://doi.org/10.1182/blood-2015-12-688051
To the editor: Cancer cells produce unique heterogeneous vesicles[1][1] capable of transferring oncogenic material[2][2],[3][3] to other cells,[4][4],[5][5] with the potential of modulating a tumor-supportive environment.[6][6][⇓][7]-[8][8] We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba52a3db556c8f96a91b4cf541252b98
http://europepmc.org/abstract/med/27099150
http://europepmc.org/abstract/med/27099150
