Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Owen B, Wallace"'
Autor:
Nicholas A, Meanwell, Owen B, Wallace, Haiquan, Fang, Henry, Wang, Milind, Deshpande, Tao, Wang, Zhiwei, Yin, Zhongxing, Zhang, Bradley C, Pearce, Jennifer, James, Kap-Sun, Yeung, Zhilei, Qiu, J J, Kim Wright, Zheng, Yang, Lisa, Zadjura, Donald L, Tweedie, Suresh, Yeola, Fang, Zhao, Sunanda, Ranadive, Brett A, Robinson, Yi-Fei, Gong, Hwei-Gene Heidi, Wang, Timothy P, Spicer, Wade S, Blair, Pei-Yong, Shi, Richard J, Colonno, Pin-Fang, Lin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1977-1981
The effects of introducing simple halogen, alkyl, and alkoxy substituents to the 4, 5, 6 and 7 positions of 1-(4-benzoylpiperazin-1-yl)-2-(1H-indol-3-yl)ethane-1,2-dione, an inhibitor of the interaction between HIV gp120 and host cell CD4 receptors,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2259bba44f301feaba94a75914776769
https://doi.org/10.1016/j.bmcl.2009.02.040
https://doi.org/10.1016/j.bmcl.2009.02.040
Autor:
Samuel W. Oldham, Hongqi Tian, Ilene R. Cohen, Ronald Jay Hinklin, Jeffrey Alan Dodge, Timothy Ivo Richardson, Christian Alexander Clarke, Bai-Ping Ying, Kin Chiu Fong, Daniel G. Rudmann, Minmin Wang, Daniel Timothy Kohlman, Owen B. Wallace, Denis J. McCann, George Sal Lewis, Alan David Palkowitz, David E. Coutant, Andrew G. Geiser, Robert Dean Dally, Conrad Wilson Hummel, Henry Uhlman Bryant, Timothy Alan Shepherd, Judith W. Henck, Scott Alan Jones, Scott Alan Frank
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3544-3549
Structure–activity relationship studies are described, which led to the discovery of novel selective estrogen receptor modulators (SERMs) for the potential treatment of uterine fibroids. The SAR studies focused on limiting brain exposure and were g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f03ed26424ecf7ba8595f90e0bdaddb
https://doi.org/10.1016/j.bmcl.2007.04.044
https://doi.org/10.1016/j.bmcl.2007.04.044
Autor:
Garry Pairaudeau, William Pennie, Sam Mandrell, Robert M. Owen, John Arrowsmith, Jibo Wang, Owen B. Wallace, Andrew R. Leach, Alex Weir, Paul D. Leeson, Michael J. Waring, Stephen D. Pickett
Publikováno v:
Nature reviews. Drug discovery. 14(7)
The pharmaceutical industry remains under huge pressure to address the high attrition rates in drug development. Attempts to reduce the number of efficacy- and safety-related failures by analysing possible links to the physicochemical properties of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd496f56c5fc26c913ee072fedfe5f5c
https://pubmed.ncbi.nlm.nih.gov/26091267
https://pubmed.ncbi.nlm.nih.gov/26091267
Autor:
Thomas P. Burris, Owen B. Wallace, Jeffrey Alan Dodge, Joel R. Calvin, Scott A. May, Kenneth S Lauwers, Andrew G. Geiser, Ronald Jay Hinklin, Pamela K. Shetler, Mary D. Adrian, Masahiko Sato, Henry Uhlman Bryant
Publikováno v:
Journal of Medicinal Chemistry. 49:843-846
A selective estrogen receptor modulator (SERM) for the potential treatment of hot flushes is described. (R)-(+)-7,9-difluoro-5-[4-(2-piperidin-1-ylethoxy)phenyl]-5H-6-oxachrysen-2-ol, LSN2120310, potently binds ERalpha and ERbeta and is an antagonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855f72212cafc3f21a8e6957d875b7ec
https://doi.org/10.1021/jm0509795
https://doi.org/10.1021/jm0509795
Autor:
George Sal Lewis, Andrew G. Geiser, Ilene R. Cohen, Kin Chiu Fong, Minmin Wang, Owen B. Wallace, Robert Dean Dally, Yong Wang, Timothy Alan Shepherd, Denis J. McCann, Jeffrey Alan Dodge, Conrad Wilson Hummel, Scott Alan Jones, Ronald Jay Hinklin, Daniel G. Rudmann, Hongqi Tian, Scott Alan Frank, Henry Uhlman Bryant
Publikováno v:
Journal of Medicinal Chemistry. 48:6772-6775
The design of a novel selective estrogen receptor modulator (SERM) for the potential treatment of uterine leiomyoma is described. 16 (LY2066948-HCl) binds with high affinity to estrogen receptors alpha and beta (ERalpha and ERbeta, respectively) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035ba26a2e2bd672357f394edbda7cb6
https://doi.org/10.1021/jm050723z
https://doi.org/10.1021/jm050723z
Autor:
Andrew G. Geiser, Draper Michael William, Mary D. Adrian, Denis J. McCann, Owen B. Wallace, Judith W. Henck, Kevin B. Donnelly, Conrad Wilson Hummel, Jeffrey Alan Dodge, Henry Uhlman Bryant, Ilene R. Cohen, Masahiko Sato, Timothy Alan Shepherd, Daniel G. Rudmann, Samuel W. Oldham
Publikováno v:
Endocrinology. 146:4524-4535
The use of selective estrogen receptor modulators for the treatment of estrogen-dependent diseases in premenopausal women has been hindered by undesirable ovarian stimulation and associated risks of ovarian cysts. We have identified a selective estro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39de85325e8a1b26792e6e1ec5de063a
https://doi.org/10.1210/en.2005-0024
https://doi.org/10.1210/en.2005-0024
Autor:
Frederick E. Ziegler, Owen B. Wallace
Publikováno v:
The Journal of Organic Chemistry. 60:3626-3636
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::948574a25991f1d8450405259b75ac1b
https://doi.org/10.1021/jo00117a011
https://doi.org/10.1021/jo00117a011
Autor:
Nicholas A, Meanwell, Owen B, Wallace, Henry, Wang, Milind, Deshpande, Bradley C, Pearce, Ashok, Trehan, Kap-Sun, Yeung, Zhilei, Qiu, J J Kim, Wright, Brett A, Robinson, Yi-Fei, Gong, Hwei-Gene Heidi, Wang, Timothy P, Spicer, Wade S, Blair, Pei-Yong, Shi, Pin-fang, Lin
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(17)
1-(4-Benzoylpiperazin-1-yl)-2-(1H-indol-3-yl)ethane-1,2-dione (1a) has been characterized as an inhibitor of HIV-1 attachment that interferes with the interaction of viral gp120 with the host cell receptor CD4. In previous studies, the effect of indo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8334da27fbdf4faf9255eacbce552fb7
https://pubmed.ncbi.nlm.nih.gov/19632112
https://pubmed.ncbi.nlm.nih.gov/19632112
Publikováno v:
ChemInform. 36
For selective estrogen receptor modulators (SERMs), the orientation of the basic side chain relative to the SERM core has a significant impact on function. The synthesis and biological evaluation of two series of SERMs are disclosed, where the ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f794f7238f0a47d9067dd7998a5d7742
https://doi.org/10.1002/chin.200504152
https://doi.org/10.1002/chin.200504152
Autor:
C V C, Prasad, Owen B, Wallace, Jeffrey W, Noonan, Charles P, Sloan, Wai, Lau, Shikha, Vig, Michael F, Parker, David W, Smith, Steven B, Hansel, Craig T, Polson, Donna M, Barten, Kevin M, Felsenstein, Susan B, Roberts
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(8)
Using a cell-based assay, we have identified optimal residues and key recognition elements necessary for inhibition of gamma-secretase. An (S)-hydroxy group or 3,5-difluorophenylacetyl group at the amino terminus and N-methyltertiary amide moiety at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216cca58efa4310505e38e5be20e637b
https://pubmed.ncbi.nlm.nih.gov/15050627
https://pubmed.ncbi.nlm.nih.gov/15050627