Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Owen B, McManus"'
Autor:
Gabriel B. Borja, Hongkang Zhang, Benjamin N. Harwood, Jane Jacques, Jennifer Grooms, Romina O. Chantre, Dawei Zhang, Adam Barnett, Christopher A. Werley, Yang Lu, Steven F. Nagle, Owen B. McManus, Graham T. Dempsey
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Optogenetic assays provide a flexible, scalable, and information rich approach to probe compound effects for ion channel drug targets in both heterologous expression systems and associated disease relevant cell types. Despite the potential utility an
Externí odkaz:
https://doaj.org/article/fbccbcbdfa4349c68b6c7eb8e5f3089d
Autor:
Pin W. Liu, Hongkang Zhang, Christopher A. Werley, Monika Pichler, Steve Ryan, Caitlin Lewarch, Jane Jacques, Jennifer Grooms, John Ferrante, Guangde Li, Dawei Zhang, Nate Bremmer, Adam Barnett, Romina Chantre, Amy E. Elder, Adam E. Cohen, Luis A. Williams, Graham T. Dempsey, Owen B. McManus
Chronic pain associated with osteoarthritis (OA) remains an intractable problem with few effective treatment options. New approaches are needed to model the disease biology and to drive discovery of therapeutics. Here, we present anin vitromodel of O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::088799b6f5f999c7b434c1b6a4461ccb
https://doi.org/10.1101/2022.12.12.520139
https://doi.org/10.1101/2022.12.12.520139
Autor:
Dina Simkin, Christina Ambrosi, Kelly A. Marshall, Luis A. Williams, Jordyn Eisenberg, Mennat Gharib, Graham T. Dempsey, Alfred L. George, Owen B. McManus, Evangelos Kiskinis
Publikováno v:
Trends Pharmacol Sci
Induced pluripotent stem cell (iPSC) and gene editing technologies have revolutionized the field of in vitro disease modeling, granting us access to disease-pertinent human cells of the central nervous system. These technologies are particularly well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30dfd020322e7bbc3d826e842e56c497
https://europepmc.org/articles/PMC9119009/
https://europepmc.org/articles/PMC9119009/
Autor:
Owen B. McManus, Vivian Hecht, Violeta Yu, Chris M Hempel, Graham T. Dempsey, Ryan J. Babcock, Michael Jarosh, Joseph G. McGivern, Hongkang Zhang, Kevin Dong, Bryan D. Moyer, Christopher A. Werley
Publikováno v:
SLAS Discovery. 25:434-446
The voltage-gated sodium channel Nav1.7 is a genetically validated target for pain; pharmacological blockers are promising as a new class of nonaddictive therapeutics. The search for Nav1.7 subtype selective inhibitors requires a reliable, scalable,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b158bb79b66d537a5d39c6d8bdd18fe7
https://doi.org/10.1177/2472555220914532
https://doi.org/10.1177/2472555220914532
Autor:
Owen B. McManus, Yalan Zhang, Leonard K. Kaczmarek, Heather McClure, David J. Gerber, Imran H. Quraishi, Siddharth Kale, Luis A. Williams, Sudhir Agrawal, Graham T. Dempsey, Yung-Chih Cheng
Publikováno v:
FASEB J
Mutations in KCNC3, the gene that encodes the Kv3.3 voltage dependent potassium channel, cause Spinocerebellar Ataxia type 13 (SCA13), a disease associated with disrupted motor behaviors, progressive cerebellar degeneration, and abnormal auditory pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e2e9d9ea8e5f1ef52b0be029bc7458
https://pubmed.ncbi.nlm.nih.gov/34820911
https://pubmed.ncbi.nlm.nih.gov/34820911
Autor:
Kurt Rasmussen, Heather E. Gorby, Christian C. Felder, Owen B. McManus, Matthew D. Hall, Samantha G. Jonson, G. Sitta Sittampalam, Amir P. Tamiz, Nathan P. Coussens
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 371:396-408
Opioid misuse and addiction are a public health crisis resulting in debilitation, deaths, and significant social and economic impact. Curbing this crisis requires collaboration among academic, government, and industrial partners toward the developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ee2793133b25ede846b1de64776184
https://doi.org/10.1124/jpet.119.259408
https://doi.org/10.1124/jpet.119.259408
Autor:
Gabriel B, Borja, Himali, Shroff, Hansini, Upadhyay, Pin W, Liu, Valeriya, Baru, Yung-Chih, Cheng, Owen B, McManus, Luis A, Williams, Graham T, Dempsey, Christopher A, Werley
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2191
Optogenetics provides a powerful approach for investigating neuronal electrophysiology at the scale required for drug discovery applications. Probing synaptic function with high throughput using optogenetics requires robust tools that enable both pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8060881a314c8e3cd5a056924005c70
https://pubmed.ncbi.nlm.nih.gov/32865742
https://pubmed.ncbi.nlm.nih.gov/32865742
Autor:
Graham T. Dempsey, Pin W. Liu, Hansini Upadhyay, Gabriel B. Borja, Christopher A. Werley, Valeriya Baru, Himali Shroff, Luis A. Williams, Yung-Chih Cheng, Owen B. McManus
Publikováno v:
Methods in Molecular Biology ISBN: 9781071608296
Optogenetics provides a powerful approach for investigating neuronal electrophysiology at the scale required for drug discovery applications. Probing synaptic function with high throughput using optogenetics requires robust tools that enable both pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfb35627916d5e37a95faa9e16f9544b
https://doi.org/10.1007/978-1-0716-0830-2_8
https://doi.org/10.1007/978-1-0716-0830-2_8
Autor:
Hongkang, Zhang, Bryan D, Moyer, Violeta, Yu, Joseph G, McGivern, Michael, Jarosh, Christopher A, Werley, Vivian C, Hecht, Ryan J, Babcock, Kevin, Dong, Graham T, Dempsey, Owen B, McManus, Chris M, Hempel
Publikováno v:
SLAS discovery : advancing life sciences RD. 25(5)
The voltage-gated sodium channel Nav1.7 is a genetically validated target for pain; pharmacological blockers are promising as a new class of nonaddictive therapeutics. The search for Nav1.7 subtype selective inhibitors requires a reliable, scalable,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0fd21ab9bf663c041689f61b02b49514
https://pubmed.ncbi.nlm.nih.gov/32292096
https://pubmed.ncbi.nlm.nih.gov/32292096
Autor:
Christopher P. Austin, Rajarshi Guha, Madhu Lal-Nag, Bart Trawick, Michelle R. Arkin, Timothy L. Foley, Philip W. Iversen, Jonathan B. Baell, Thomas D.Y. Chung, Zhuyin Li, Eric W. Sayers, Neely Gal-Edd, James McGee, Owen B. McManus, Hanguan Liu, Nathan P. Coussens, Xin Xu, Viswanath Devanaryan, Marilu A. Hoeppner, Matthew D. Hall, Bruce E. Bejcek, Vance Lemmon, Kyle R. Brimacombe, Jeffrey R. Weidner, Jayme L. Dahlin, Andrew D. Napper, Steven D. Kahl, Anton Simeonov, James Inglese, Robert Pacifici, G. Sitta Sittampalam, Lisa Minor, William W. Chin, Abigail Grossman, Julie McVey, Sam Michael, Douglas S. Auld, Stacy Lathrop, Menghang Xia, Terry L. Riss, Mary Jo Wildey, Marcie A. Glicksman, Joseph V. Haas, Stephen C. Kales, O. Joseph Trask
Publikováno v:
Clinical and Translational Science. 11:461-470
The Assay Guidance Manual (AGM) is an eBook of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a "tes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea813b272dbe37c2f6c6dd728cfe4c1b
https://doi.org/10.1111/cts.12570
https://doi.org/10.1111/cts.12570