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pro vyhledávání: '"Owen Addis Jones"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
The kinase PLK1 has important roles during cell division, including mitotic entry and bipolar spindle formation. Here, the authors show that PLK1 also functions in centromere protection, with loss leading to DNA unwinding by Bloom’s syndrome helica
Externí odkaz:
https://doaj.org/article/4c92908d8a3140aca54c75ace50338bb
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Chromosome instability is associated with cancer formation. Here the authors identify in cultured human cancer cells a non-canonical DNA bridge breakage pathway leading to chromosome missegregation and rearrangements triggered by sister DNA intertwin
Externí odkaz:
https://doaj.org/article/86ed0002a60649d9aed9d1b084c12758
Faithful chromosome segregation cannot be achieved without proper chromosome biorientation (so-called metaphase alignment). Disabling PLK1, a key mitotic kinase, impairs multiple aspects of mitosis, particularly chromosome alignment. This is believed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e120650383237c35abfc9e82dc5affc9
https://doi.org/10.1101/498808
https://doi.org/10.1101/498808
