Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Owen A, Davis"'
Autor:
Olivier A. Pierrat, Manjuan Liu, Gavin W. Collie, Kartika Shetty, Matthew J. Rodrigues, Yann-Vaï Le Bihan, Emma A. Gunnell, P. Craig McAndrew, Mark Stubbs, Martin G. Rowlands, Norhakim Yahya, Erald Shehu, Rachel Talbot, Lisa Pickard, Benjamin R. Bellenie, Kwai-Ming J. Cheung, Ludovic Drouin, Paolo Innocenti, Hannah Woodward, Owen A. Davis, Matthew G. Lloyd, Ana Varela, Rosemary Huckvale, Fabio Broccatelli, Michael Carter, David Galiwango, Angela Hayes, Florence I. Raynaud, Christopher Bryant, Steven Whittaker, Olivia W. Rossanese, Swen Hoelder, Rosemary Burke, Rob L. M. van Montfort
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract By suppressing gene transcription through the recruitment of corepressor proteins, B-cell lymphoma 6 (BCL6) protein controls a transcriptional network required for the formation and maintenance of B-cell germinal centres. As BCL6 deregulatio
Externí odkaz:
https://doaj.org/article/0430233ed30549f9969eadd4d689eff3
Autor:
Pietro Bortoletto, M.D., Stephanie F. Willson, M.D., Phillip A. Romanski, M.D., Owen K. Davis, M.D., Zev Rosenwaks, M.D.
Publikováno v:
F&S Reports, Vol 1, Iss 3, Pp 239-242 (2020)
Objective: To describe the patient and cycle characteristics of women who undergo intrauterine insemination (IUI) immediately after an unsuccessful oocyte retrieval. Design: Retrospective case series. Setting: University-affiliated center. Patient(s)
Externí odkaz:
https://doaj.org/article/cad498d90d1743cea581a6422b2a15ab
Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones
Autor:
Alice C. Harnden, Owen A. Davis, Gary M. Box, Angela Hayes, Louise D. Johnson, Alan T. Henley, Alexis K. de Haven Brandon, Melanie Valenti, Kwai-Ming J. Cheung, Alfie Brennan, Rosemary Huckvale, Olivier A. Pierrat, Rachel Talbot, Michael D. Bright, Hafize Aysin Akpinar, Daniel S. J. Miller, Dalia Tarantino, Sharon Gowan, Selby de Klerk, Peter Craig McAndrew, Yann-Vaï Le Bihan, Mirco Meniconi, Rosemary Burke, Vladimir Kirkin, Rob L. M. van Montfort, Florence I. Raynaud, Olivia W. Rossanese, Benjamin R. Bellenie, Swen Hoelder
Publikováno v:
Journal of Medicinal Chemistry. 66:5892-5906
Publikováno v:
Journal of Pension Economics and Finance. :1-15
This paper uses the Current Population Survey to study older workers' transitions out of employment and into retirement during the first year of the pandemic. We find that, among workers ages 55 to 79, the likelihood of leaving employment over the co
Publikováno v:
Quaternary Research. 113:69-86
The impact of Indigenous populations on historical fire regimes has been controversial and beset by mismatches in the geographic scale of paleofire reconstructions and the scale of land-use behaviors. It is often assumed that anthropogenic burning is
Autor:
Owen A. Davis, Kwai-Ming J. Cheung, Alfie Brennan, Matthew G. Lloyd, Matthew J. Rodrigues, Olivier A. Pierrat, Gavin W. Collie, Yann-Vaï Le Bihan, Rosemary Huckvale, Alice C. Harnden, Ana Varela, Michael D. Bright, Paul Eve, Angela Hayes, Alan T. Henley, Michael D. Carter, P. Craig McAndrew, Rachel Talbot, Rosemary Burke, Rob L. M. van Montfort, Florence I. Raynaud, Olivia W. Rossanese, Mirco Meniconi, Benjamin R. Bellenie, Swen Hoelder
Publikováno v:
Journal of Medicinal Chemistry. 65:8169-8190
To identify new chemical series with enhanced binding affinity to the BTB domain of B-cell lymphoma 6 protein, we targeted a subpocket adjacent to Val18. With no opportunities for strong polar interactions, we focused on attaining close shape complem
Autor:
Rosemary Huckvale, Alice C. Harnden, Kwai-Ming J. Cheung, Olivier A. Pierrat, Rachel Talbot, Gary M. Box, Alan T. Henley, Alexis K. de Haven Brandon, Albert E. Hallsworth, Michael D. Bright, Hafize Aysin Akpinar, Daniel S. J. Miller, Dalia Tarantino, Sharon Gowan, Angela Hayes, Emma A. Gunnell, Alfie Brennan, Owen A. Davis, Louise D. Johnson, Selby de Klerk, Craig McAndrew, Yann-Vaï Le Bihan, Mirco Meniconi, Rosemary Burke, Vladimir Kirkin, Rob L. M. van Montfort, Florence I. Raynaud, Olivia W. Rossanese, Benjamin R. Bellenie, Swen Hoelder
Publikováno v:
Journal of Medicinal Chemistry. 65:8191-8207
The transcriptional repressor BCL6 is an oncogenic driver found to be deregulated in lymphoid malignancies. Herein, we report the optimization of our previously reported benzimidazolone molecular glue-type degrader
Autor:
Rob L. M. van Montfort, Kwai-Ming J. Cheung, L. Johnson, Mirco Meniconi, Florence I. Raynaud, P. Craig McAndrew, Rosemary Huckvale, Gavin W. Collie, Alan T. Henley, Olivier A. Pierrat, Emma Gunnell, Michael Carter, Matthew J. Rodrigues, Yann-Vaï Le Bihan, Mahad Gatti Iou, Matthew Garth Lloyd, Angela Hayes, Benjamin R. Bellenie, Rosemary Burke, Rachel Talbot, Olivia W. Rossanese, Michael D. Bright, Swen Hoelder, Owen Alexander Davis
Publikováno v:
Journal of Medicinal Chemistry
'Journal of Medicinal Chemistry ', vol: 64, pages: 17079-17097 (2021)
'Journal of Medicinal Chemistry ', vol: 64, pages: 17079-17097 (2021)
We describe the optimization of modestly active starting points to potent inhibitors of BCL6 by growing into a subpocket, which was occupied by a network of five stably bound water molecules. Identifying potent inhibitors required not only forming ne
Publikováno v:
Reproductive BioMedicine Online. 42:1181-1186
Do women of racial minorities aged 40 years or older have similar reproductive and obstetric outcomes as white women undergoing IVF?A retrospective cohort study conducted at a single academic university-affiliated centre. The study population include
Autor:
Hannah Woodward, Kwai-Ming J. Cheung, Paolo Innocenti, L. Johnson, Benjamin R. Bellenie, Florence I. Raynaud, Olivia W. Rossanese, Sharon Gowan, Vladimir Kirkin, Michael D. Bright, Alan T. Henley, Gavin W. Collie, Selby de Klerk, Olivier A. Pierrat, Rachel Talbot, Michael Carter, Yann-Vaï Le Bihan, Angela Hayes, Matthew Garth Lloyd, Manjuan Liu, Swen Hoelder, Rosemary Burke, Erald Shehu, Ana Varela, Matthew J. Rodrigues, Owen Alexander Davis, P. Craig McAndrew, Kartika N. Shetty, Gary Box, Rob L. M. van Montfort
Publikováno v:
Journal of Medicinal Chemistry. 63:4047-4068
Deregulation of the transcriptional repressor BCL6 enables tumorigenesis of germinal center B-cells, and hence BCL6 has been proposed as a therapeutic target for the treatment of diffuse large B-cell lymphoma (DLBCL). Herein we report the discovery o