Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Owen, Sansom"'
Autor:
Marta Nowak, Faiz Jabbar, Ann-Katrin Rodewald, Luciana Gneo, Tijana Tomasevic, Andrea Harkin, Tim Iveson, Mark Saunders, Rachel Kerr, Karin Oein, Noori Maka, Jennifer Hay, Joanne Edwards, Ian Tomlinson, Owen Sansom, Caroline Kelly, Francesco Pezzella, David Kerr, Alistair Easton, Enric Domingo, Viktor H. Koelzer, David N. Church, Bengt Glimelius, Ismail Gogenur, Emma Jaeger, Hannah Morgan, Clare Orange, Claire Palles, Campbell Roxburgh
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101727- (2024)
Summary: Testing for DNA mismatch repair deficiency (MMRd) is recommended for all colorectal cancers (CRCs). Automating this would enable precision medicine, particularly if providing information on etiology not captured by deep learning (DL) methods
Externí odkaz:
https://doaj.org/article/0addef455aaa46a896ad776bd6ad5c75
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 8 (2024)
Externí odkaz:
https://doaj.org/article/afeda00d81fc425d88698a355a988795
Autor:
Owen Sansom
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 9 (2022)
Over the past 20 years, the UK has become a leading force in the generation and use of complex mouse models in the precise investigation of human disease. Nevertheless, there remains a great challenge in improving how research in animals is translate
Externí odkaz:
https://doaj.org/article/26beae078a364cd2a4ccf099666e9f56
Autor:
Antonia K Roseweir, James H Park, Sanne ten Hoorn, Arfon GMT Powell, Susan Aherne, Campbell SD Roxburgh, Donald C McMillan, Paul G Horgan, Elizabeth Ryan, Kieran Sheahan, Louis Vermeulen, James Paul, Andrea Harkin, Janet Graham, Owen Sansom, David N Church, Ian Tomlinson, Mark Saunders, Tim J Iveson, Joanne Edwards
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 6, Iss 4, Pp 283-296 (2020)
Abstract Histological ‘phenotypic subtypes’ that classify patients into four groups (immune, canonical, latent and stromal) have previously been demonstrated to stratify survival in a stage I–III colorectal cancer (CRC) pilot cohort. However, c
Externí odkaz:
https://doaj.org/article/86ccccce88334b4890153382c13043e0
Autor:
Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Kras is often mutated in colorectal cancer but how this oncogenic mutation alters signalling pathways globally is undetermined. Here, the authors analyse how this mutation affects protein interaction networks and signal flow showing an extensive re
Externí odkaz:
https://doaj.org/article/9d3d9f430d2e481298f1f134583ff8b6
Autor:
Anja Laura Frei, Anthony McGuigan, Ritik RAK Sinha, Mark A Glaire, Faiz Jabbar, Luciana Gneo, Tijana Tomasevic, Andrea Harkin, Tim Iveson, Mark Saunders, Karin Oien, Noori Maka, Francesco Pezzella, Leticia Campo, Jennifer Hay, Joanne Edwards, Owen Sansom, Caroline Kelly, Ian Tomlinson, Wanja Kildal, Rachel Kerr, David Kerr, Havard Emil Danielsen, Enric Domingo, David N Church, Viktor Hendrik Koelzer
Background: Tumour immunoprofiling captures tumour-microenvironment interactions and enables precision medicine. Multiplex immunofluorescence (mIF) imaging can provide comprehensive quantitative and spatial information for multiple immune markers. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f8335b8a6f4dafad80bfbed52bc50e1
https://doi.org/10.1101/2023.05.19.23290216
https://doi.org/10.1101/2023.05.19.23290216
Autor:
Uwe Ueberham, Rolf Gebhardt, Owen Sansom, Thomas Arendt, Frank Gaunitz, Walter Birchmeier, Boris Jerchow, Anne Kathrin Höhn, Albert Braeuning, Kai Schönig, Daniel Teupser, Beate K. Straub, Claudia Göhler, Pia Glöckner, Elke Ueberham
Immunohistochemical depiction of p16INK4a in situ.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0749e19c10eed2349f0396ef318060b5
https://doi.org/10.1158/1541-7786.22515451.v1
https://doi.org/10.1158/1541-7786.22515451.v1
Autor:
Uwe Ueberham, Rolf Gebhardt, Owen Sansom, Thomas Arendt, Frank Gaunitz, Walter Birchmeier, Boris Jerchow, Anne Kathrin Höhn, Albert Braeuning, Kai Schönig, Daniel Teupser, Beate K. Straub, Claudia Göhler, Pia Glöckner, Elke Ueberham
List of transgenic mice used in the study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166bbd23ff79634ef1b83fa34bf925c4
https://doi.org/10.1158/1541-7786.22515439.v1
https://doi.org/10.1158/1541-7786.22515439.v1
Autor:
Uwe Ueberham, Rolf Gebhardt, Owen Sansom, Thomas Arendt, Frank Gaunitz, Walter Birchmeier, Boris Jerchow, Anne Kathrin Höhn, Albert Braeuning, Kai Schönig, Daniel Teupser, Beate K. Straub, Claudia Göhler, Pia Glöckner, Elke Ueberham
Supplementary Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a3e7639cd80efcae9cd256a7e82386
https://doi.org/10.1158/1541-7786.22515463
https://doi.org/10.1158/1541-7786.22515463
Autor:
Uwe Ueberham, Rolf Gebhardt, Owen Sansom, Thomas Arendt, Frank Gaunitz, Walter Birchmeier, Boris Jerchow, Anne Kathrin Höhn, Albert Braeuning, Kai Schönig, Daniel Teupser, Beate K. Straub, Claudia Göhler, Pia Glöckner, Elke Ueberham
Reduction of β-catenin (CTNNB1) destroying complex components, for example, adenomatous polyposis coli (APC), induces β-catenin signaling and subsequently triggers activation of genes involved in proliferation and tumorigenesis. Though diminished e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bb226c94ab91a17f001ec6b1daa7239
https://doi.org/10.1158/1541-7786.c.6541087
https://doi.org/10.1158/1541-7786.c.6541087